Outputs (233)

Programming of pluripotency and the germline co-evolved from a Nanog ancestor (2025)
Journal Article
Crowley, D., Simpson, L., Chatfield, J., Forey, T., Allegrucci, C., Sang, F., Holmes, N., Genikhovich, G., Technau, U., Cunningham, D., Silva, E., Mullin, N., Dixon, J. E., Loose, M., Alberio, R., & Johnson, A. D. (2025). Programming of pluripotency and the germline co-evolved from a Nanog ancestor. Cell Reports, 44(3), Article 115396. https://doi.org/10.1016/j.celrep.2025.115396

Francois Jacob proposed that evolutionary novelty arises through incremental tinkering with pre-existing genetic mechanisms. Vertebrate evolution was predicated on pluripotency—the ability of embryonic cells to form somatic germ-layers and primordial... Read More about Programming of pluripotency and the germline co-evolved from a Nanog ancestor.

Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts (2025)
Journal Article
Fakae, L. B., Zhong, J., Chan, K. L. A., Mekapothula, S., Cave, G. W., Zhu, X.-Q., Stevenson, C. W., & Elsheikha, H. M. (2025). Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts. Acta Parasitologica, 70(2), Article 63. https://doi.org/10.1007/s11686-024-00941-9

Purpose Acanthamoeba castellanii is an important opportunistic human protozoal pathogen that can cause both skin, ocular and brain infections. Recent studies have established that brews and solvent extract (SE) of green tea (Camellia sinensis) can in... Read More about Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts.

Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats (2025)
Preprint / Working Paper
Renstrom, J. G., Taylor, C. J. L., Grasmeder Allen, R., Loayza, J., O'Hara, L., von Heimendahl, M., Deiana, S., Moran, P. M., Stevenson, C. W., Maggi, S. G., & Bast, T. (2025). Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats

Schizophrenia has been linked to hypofrontality (reduced prefrontal activation) and neural disinhibition (reduced GABAergic inhibition) within the dorsolateral prefrontal cortex (dlPFC), as well as reversal learning deficits. Interestingly, whilst re... Read More about Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats.

Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep (2025)
Journal Article
Thangaraj, S. V., Bellingham, M., Lea, R., Evans, N., Sinclair, K., & Padmanabhan, V. (2025). Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep. Environmental Pollution, 367, Article 125630. https://doi.org/10.1016/j.envpol.2025.125630

Humans are chronically exposed to a mixture of environmental chemicals (ECs), many with metabolic and endocrine disrupting potential, contributing to non-communicable disease burden. Understanding the effects of chronic exposure to low-level mixtures... Read More about Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep.

Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction (2024)
Journal Article
Sinclair, K. D. (2024). Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction. Journal of Dairy Science, https://doi.org/10.3168/jds.2024-25811

The developmental integrity and wellbeing of offspring are influenced by events that occur in utero, particularly around the time of conception. While extraneous factors such as environmental temperature and exposure to environmental chemicals can ea... Read More about Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction.

Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes (2024)
Journal Article
Sudman, M., Stöger, R., Bentley, G. R., & Melamed, P. (2024). Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes. European Journal of Endocrinology, 191(6), 623-635. https://doi.org/10.1093/ejendo/lvae156

Objective
High concentrations of dehydroepiandrosterone sulfate (DHEAS) often precede premature puberty and sometimes polycystic ovary syndrome (PCOS). We hypothesized that the underlying mechanisms might involve DNA methylation. As an indicator of... Read More about Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes.

Peeking into the future: inferring mechanics in dynamical tissues (2024)
Journal Article
Borges, A., & Chara, O. (2024). Peeking into the future: inferring mechanics in dynamical tissues. Biochemical Society Transactions, 52(6), 2579-2592. https://doi.org/10.1042/BST20230225

Cells exert forces on each other and their environment, shaping the tissue. The resulting mechanical stresses can be determined experimentally or estimated computationally using stress inference methods. Over the years, mechanical stress inference ha... Read More about Peeking into the future: inferring mechanics in dynamical tissues.

Smarter Pregnancy Coaching and Maternal Blood Pressure (2024)
Journal Article
Hojeij, B., Schoenmakers, S., Van Mullem, I., Willemsen, S. P., Dinnyes, A., Sinclair, K. D., Rousian, M., & Steegers-Theunissen, R. P. (2025). Smarter Pregnancy Coaching and Maternal Blood Pressure. American Journal of Preventive Medicine, 68(3), 455-464. https://doi.org/10.1016/j.amepre.2024.11.007

Introduction
Maternal lifestyle behaviors can affect blood pressure with consequences for maternal and offspring health. The aim of this study was to investigate the effectiveness of the Smarter Pregnancy digital lifestyle coaching program on matern... Read More about Smarter Pregnancy Coaching and Maternal Blood Pressure.

Ovarian follicular flushing as a means of increasing oocyte yield and in vitro embryo production in cattle (2024)
Journal Article
Simmons, R. J., Tutt, D. A., Kwong, W. Y., Baroni, J. I., Lim, L. N., Cimpeanu, R., Castrejon-Pita, A. A., Vatish, M., Svensson, P., Piegsa, R., Hagby, U., Sinclair, K. D., Sinclair, K. D., & Georgiou, E. X. (2024). Ovarian follicular flushing as a means of increasing oocyte yield and in vitro embryo production in cattle. Reproduction, Fertility and Development, 36(17), Article RD24125. https://doi.org/10.1071/rd24125

Context The number of developmentally competent cumulus-oocyte complexes (COCs) retrieved during Ovum Pick-Up (OPU) determines success in both bovine and human assisted reproduction. Follicular flushing for COC retrieval is practicsed widely in human... Read More about Ovarian follicular flushing as a means of increasing oocyte yield and in vitro embryo production in cattle.

Developmental programming: preconceptional and gestational exposure of sheep to biosolids on offspring ovarian dynamics (2024)
Journal Article
Halloran, K. M., Zhou, Y., Bellingham, M., Lea, R. G., Evans, N. P., Sinclair, K. D., Smith, P., & Padmanabhan, V. (2025). Developmental programming: preconceptional and gestational exposure of sheep to biosolids on offspring ovarian dynamics. Biology of Reproduction, 112(2), 331-345. https://doi.org/10.1093/biolre/ioae166

Developmental exposure to environmental chemicals perturbs establishment and maintenance of the ovarian reserve across the reproductive lifetime, leading to premature follicle depletion and ovarian aging. Considering humans are exposed to a complex m... Read More about Developmental programming: preconceptional and gestational exposure of sheep to biosolids on offspring ovarian dynamics.