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Outputs (282)

First-trimester maternal folate and vitamin B12 concentrations and their associations with first-trimester placental growth: the Rotterdam Periconception Cohort (2025)
Journal Article
van Vliet, M. M., Schoenmakers, S., Willemsen, S. P., Sinclair, K. D., & Steegers-Theunissen, R. P. M. (2025). First-trimester maternal folate and vitamin B12 concentrations and their associations with first-trimester placental growth: the Rotterdam Periconception Cohort. Human Reproduction, https://doi.org/10.1093/humrep/deaf095

Study question: Are maternal folate and vitamin B12 concentrations associated with first-trimester placental growth?

Summary answer: Maternal folate concentrations and commencement of folic acid supplements prior to conception, as compared to foll... Read More about First-trimester maternal folate and vitamin B12 concentrations and their associations with first-trimester placental growth: the Rotterdam Periconception Cohort.

STAT3 signaling enhances tissue expansion during postimplantation mouse development (2025)
Journal Article
Azami, T., Theeuwes, B., Ton, M.-L. N., Mansfield, W., Harland, L., Kinoshita, M., Gottgens, B., & Nichols, J. (2025). STAT3 signaling enhances tissue expansion during postimplantation mouse development. Cell Reports, 44(4), Article 115506. https://doi.org/10.1016/j.celrep.2025.115506

Signal transducer and activator of transcription (STAT)3 signaling has been studied extensively using mouse embryonic stem cells. Zygotic deletion of Stat3 enables embryo implantation, but thereafter, mutants resemble non-affected littermates from th... Read More about STAT3 signaling enhances tissue expansion during postimplantation mouse development.

Programming of pluripotency and the germ line co-evolved from a Nanog ancestor (2025)
Journal Article
Crowley, D., Simpson, L., Chatfield, J., Forey, T., Allegrucci, C., Sang, F., Holmes, N., Genikhovich, G., Technau, U., Cunningham, D., Silva, E., Mullin, N., Dixon, J. E., Loose, M., Alberio, R., & Johnson, A. D. (2025). Programming of pluripotency and the germ line co-evolved from a Nanog ancestor. Cell Reports, 44(3), Article 115396. https://doi.org/10.1016/j.celrep.2025.115396

Francois Jacob proposed that evolutionary novelty arises through incremental tinkering with pre-existing genetic mechanisms. Vertebrate evolution was predicated on pluripotency, the ability of embryonic cells to form somatic germ layers and primordia... Read More about Programming of pluripotency and the germ line co-evolved from a Nanog ancestor.

Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts (2025)
Journal Article
Fakae, L. B., Zhong, J., Chan, K. L. A., Mekapothula, S., Cave, G. W., Zhu, X.-Q., Stevenson, C. W., & Elsheikha, H. M. (2025). Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts. Acta Parasitologica, 70(2), Article 63. https://doi.org/10.1007/s11686-024-00941-9

Purpose: Acanthamoeba castellanii is an important opportunistic human protozoal pathogen that can cause both skin, ocular and brain infections. Recent studies have established that brews and solvent extract (SE) of green tea (Camellia sinensis) can i... Read More about Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis Extracts.

Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats (2025)
Preprint / Working Paper
Renstrom, J. G., Taylor, C. J. L., Grasmeder Allen, R., Loayza, J., O'Hara, L., von Heimendahl, M., Deiana, S., Moran, P. M., Stevenson, C. W., Maggi, S. G., & Bast, T. (2025). Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats

Schizophrenia has been linked to hypofrontality (reduced prefrontal activation) and neural disinhibition (reduced GABAergic inhibition) within the dorsolateral prefrontal cortex (dlPFC), as well as reversal learning deficits. Interestingly, whilst re... Read More about Too little and too much: medial prefrontal functional inhibition impairs early acquisition of operant reversal learning, whereas medial prefrontal disinhibition impairs established serial-reversal performance in rats.

Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep (2025)
Journal Article
Thangaraj, S. V., Bellingham, M., Lea, R., Evans, N., Sinclair, K., & Padmanabhan, V. (2025). Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep. Environmental Pollution, 367, Article 125630. https://doi.org/10.1016/j.envpol.2025.125630

Humans are chronically exposed to a mixture of environmental chemicals (ECs), many with metabolic and endocrine disrupting potential, contributing to non-communicable disease burden. Understanding the effects of chronic exposure to low-level mixtures... Read More about Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep.

Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production (2025)
Journal Article
Deelkens, C., De Vlieghere, E., Van Poucke, M., Kinoshita, M., Aalders, J., Thorrez, L., Devriendt, B., Van Soom, A., Peelman, L., Menten, B., De Schauwer, C., & van Hengel, J. (2025). Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production. Future Foods, 11, Article 100555. https://doi.org/10.1016/j.fufo.2025.100555

As the global population continues to grow, the demand for sustainable food production methods becomes increasingly critical. This study investigates the presence of chromosomal abnormalities in bovine embryonic stem cells (bESCs), which hold potenti... Read More about Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines: Implications for cultured meat production.

Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction (2024)
Journal Article
Sinclair, K. D. (2024). Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction. Journal of Dairy Science, https://doi.org/10.3168/jds.2024-25811

The developmental integrity and wellbeing of offspring are influenced by events that occur in utero, particularly around the time of conception. While extraneous factors such as environmental temperature and exposure to environmental chemicals can ea... Read More about Developmental epigenetics: Understanding genetic and sexually dimorphic responses to parental diet and outcomes following assisted reproduction.

Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes (2024)
Journal Article
Sudman, M., Stöger, R., Bentley, G. R., & Melamed, P. (2024). Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes. European Journal of Endocrinology, 191(6), 623-635. https://doi.org/10.1093/ejendo/lvae156

Objective
High concentrations of dehydroepiandrosterone sulfate (DHEAS) often precede premature puberty and sometimes polycystic ovary syndrome (PCOS). We hypothesized that the underlying mechanisms might involve DNA methylation. As an indicator of... Read More about Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes.