Outputs (289)

Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency (2022)
Journal Article
Berndt, N., Wolf, C., Fischer, K., Cura Costa, E., Knuschke, P., Zimmermann, N., Schmidt, F., Merkel, M., Chara, O., Lee-Kirsch, M. A., & Günther, C. (2022). Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency. Journal of Investigative Dermatology, 142(3), 633-640.e6. https://doi.org/10.1016/j.jid.2021.04.037

The exonuclease TREX1 safeguards the cells against DNA accumulation in the cytosol and thereby prevents innate immune activation and autoimmunity. TREX1 mutations lead to chronic DNA damage and cell-intrinsic IFN-1 response. Associated disease phenot... Read More about Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency.

Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures (2022)
Journal Article
Lea, R. G., Mandon-Pépin, B., Loup, B., Poumerol, E., Jouneau, L., Egbowon, B. F., Bowden, A., Cotinot, C., Purdie, L., Zhang, Z., Fowler, P. A., & Sinclair, K. D. (2022). Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures. Reproduction, 163(2), 119-131. https://doi.org/10.1530/REP-21-0235

Exposure of the fetal testis to numerous individual environmental chemicals (ECs) is frequently associated with dysregulated development, leading to impaired adult reproductive competence. However, 'real-life' exposure involves complex mixtures of EC... Read More about Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.

Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens (2022)
Journal Article
Ceccarelli, A. S., Borges, A., & Chara, O. (2022). Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens. Royal Society Open Science, 9(1), Article 211112. https://doi.org/10.1098/rsos.211112

The reaction–diffusion model constitutes one of the most influential mathematical models to study distribution of morphogens in tissues. Despite its widespread use, the effect of finite tissue size on model-predicted spatio-temporal morphogen distrib... Read More about Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens.

Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing (2022)
Journal Article
Bar-Sadeh, B., Amichai, O. E., Pnueli, L., Begum, K., Leeman, G., Emes, R. D., Stöger, R., Bentley, G. R., & Melamed, P. (2022). Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing. BMC Biology, 20, Article 11. https://doi.org/10.1186/s12915-021-01219-6

Background: Women facing increased energetic demands in childhood commonly have altered adult ovarian activity and shorter reproductive lifespan, possibly comprising a strategy to optimize reproductive success. Here, we sought to understand the mecha... Read More about Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing.

Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial (2022)
Journal Article
Joy, E. J., Kalimbira, A. A., Sturgess, J., Banda, L., Chiutsi-Phiri, G., Manase, H., Gondwe, J., Ferguson, E. L., Kalumikiza, Z., Bailey, E. H., Young, S. D., Matandika, L., Mfutso-Bengo, J., Millar, K., Niksic, M., Segovia de la Revilla, L., Likoswe, B. H., Phuka, J. C., Phiri, F. P., Lark, R. M., …Allen, E. (2022). Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial. Frontiers in Nutrition, 8, Article 788096. https://doi.org/10.3389/fnut.2021.788096

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agron... Read More about Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial.

Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation (2022)
Journal Article
Wainwright, J., Millar, K. M., & White, G. A. (2022). Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13469

Objectives: To investigate owners’ views around canine nutrition and wellbeing, how these beliefs may differ according to the weight status of the dog and the implications for owner support approaches. Materials and Methods: A researcher-mediated que... Read More about Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation.

Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species (2021)
Journal Article
Kinoshita, M., Kobayashi, T., Planells, B., Klisch, D., Spindlow, D., Masaki, H., Bornelöv, S., Stirparo, G. G., Matsunari, H., Uchikura, A., Lamas-Toranzo, I., Nichols, J., Nakauchi, H., Nagashima, H., Alberio, R., & Smith, A. (2021). Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species. Development, 148(23), Article dev199901. https://doi.org/10.1242/dev.199901

Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the em... Read More about Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species.

Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain (2021)
Journal Article
Sargent, C., Ebanks, B., Hardy, I. C., Davies, T. G. E., Chakrabarti, L., & Stöger, R. (2021). Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain. Frontiers in Insect Science, 1, Article 765179. https://doi.org/10.3389/finsc.2021.765179

Mitochondria are intracellular organelles responsible for cellular respiration with one of their major roles in the production of energy in the form of ATP. Activities with increased energetic demand are especially dependent on efficient ATP producti... Read More about Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain.

Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells? (2021)
Journal Article
Savage, A. M., Alberio, R., & Johnson, A. D. (2021). Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?. Biology Open, 10(10), Article bio058890. https://doi.org/10.1242/bio.058890

In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of... Read More about Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?.

Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory (2021)
Journal Article
Kinoshita, M., Li, M. A., Barber, M., Mansfield, W., Dietmann, S., & Smith, A. (2021). Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory. Proceedings of the National Academy of Sciences, 118(38), Article e2109475118. https://doi.org/10.1073/pnas.2109475118

Genome remethylation is essential for mammalian development but specific reasons are unclear. Here we examined embryonic stem (ES) cell fate in the absence of de novo DNA methyltransferases. We observed that ES cells deficient for both Dnmt3a and Dnm... Read More about Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.