Outputs (26)

The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients (2022)
Journal Article
Kouraki, A., Bast, T., Ferguson, E., & Valdes, A. M. (2022). The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients. Scientific Reports, 12(1), Article 943. https://doi.org/10.1038/s41598-022-04781-3

Previous research has established links between chronic pain and impaired cognitive ability, as well as between chronic pain and anxiety, in osteoarthritis. Furthermore, there is evidence linking risk of osteoarthritis to lower educational attainment... Read More about The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients.

Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition (2022)
Journal Article
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., Cassaday, H. J., & Bast, T. (2022). Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition. eNeuro, 9(1), ENEURO.0270-21.2021. https://doi.org/10.1523/eneuro.0270-21.2021

Hippocampal neural disinhibition, i.e., reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition.

Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations (2021)
Journal Article
Prior, M. J., Bast, T., McGarrity, S., Goldschmidt, J., Vincenz, D., Seaton, A., Hall, G., & Pitiot, A. (2021). Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations. Brain and Neuroscience Advances, 5,

There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister hooded rats despite the popularity of this strain for behavioural neuroscience studies in the UK and elsewhere. We have created a... Read More about Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations.

Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition (2021)
Preprint / Working Paper
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., Cassaday, H. J., & Bast, T. Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition

Hippocampal neural disinhibition, i.e. reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition.

Reinforcement Learning approaches to hippocampus-dependent flexible spatial navigation (2021)
Journal Article
Bast, T., Coombes, S., O’Dea, R., & Tessereau, C. (2021). Reinforcement Learning approaches to hippocampus-dependent flexible spatial navigation. Brain and Neuroscience Advances, 5, https://doi.org/10.1177/2398212820975634

Humans and non-human animals show great flexibility in spatial navigation, including the ability to return to specific locations based on as few as one single experience. To study spatial navigation in the laboratory, watermaze tasks, in which rats h... Read More about Reinforcement Learning approaches to hippocampus-dependent flexible spatial navigation.

Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning (2021)
Journal Article
Bauer, M., Buckley, M. G., & Bast, T. (2021). Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning. Brain and Neuroscience Advances, 5, 1-17. https://doi.org/10.1177/23982128211002725

Spatial memory has been closely related to the medial temporal lobe (MTL) and theta-oscillations are thought to play a key role. However, it remains difficult to investigate MTL activation related to spatial memory with non-invasive electrophysiologi... Read More about Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning.

Frequency‐ and state‐dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anesthetized rats (2020)
Journal Article
Gwilt, M., Bauer, M., & Bast, T. (2020). Frequency‐ and state‐dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anesthetized rats. Hippocampus, 30(10), 1021-1043. https://doi.org/10.1002/hipo.23212

Reduced inhibitory GABA function, so‐called neural disinhibition, has been implicated in cognitive disorders, including schizophrenia and age‐related cognitive decline. We previously showed in rats that hippocampal disinhibition by local microinfusio... Read More about Frequency‐ and state‐dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anesthetized rats.

Frequency- and state-dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anaesthetised rats (2019)
Other
Gwilt, M., Bauer, M., & Bast, T. (2019). Frequency- and state-dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anaesthetised rats

Reduced inhibitory GABA function, so-called neural disinhibition, has been implicated in cognitive disorders, including schizophrenia and age-related cognitive decline. We previously showed in rats that hippocampal disinhibition by local microinfusio... Read More about Frequency- and state-dependent effects of hippocampal neural disinhibition on hippocampal local field potential oscillations in anaesthetised rats.

Weniger ist manchmal mehr! (2019)
Journal Article
Bast, T. (2019). Weniger ist manchmal mehr!. Gehirn und Geist, 8/2019, 46-51

HIRNFORSCHUNG NEURONALE HEMMUNG Lange Zeit dachten Forscher, dass viele neurologische und psychiatrische Erkrankungen auf einer zu geringen Hirnaktivität beruhen. Doch häufig ist genau das Gegenteil der Fall.

A new human delayed-matching-to-place test in a virtual environment reverse-translated from the rodent watermaze paradigm: characterization of performance measures and sex differences (2018)
Journal Article
Buckley, M. G., & Bast, T. (2018). A new human delayed-matching-to-place test in a virtual environment reverse-translated from the rodent watermaze paradigm: characterization of performance measures and sex differences. Hippocampus, 28(11), 796-812. https://doi.org/10.1002/hipo.22992

Watermaze tests of place learning and memory in rodents, and corresponding reverse translated human paradigms in real or virtual environments, are key tools to study hippocampal function. In common variants, the animal or human participant has to fin... Read More about A new human delayed-matching-to-place test in a virtual environment reverse-translated from the rodent watermaze paradigm: characterization of performance measures and sex differences.