Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
(2025)
Preprint / Working Paper
Taylor, C. J. L., Renström, J. G., Loayza, J., Gwilt, M., Williams, S. A., Grasmeder Allen, R., Moran, P. M., Gigg, J., Neill, J., Harte, M., & Bast, T. (2025). Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
Impaired GABAergic inhibition, so-called neural disinhibition, in the prefrontal cortex and hippocampus has been linked to cognitive deficits. The novel object recognition (NOR) task has been used widely to study cognitive deficits in rodents. Howeve... Read More about Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats.