Outputs (26)

Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats (2025)
Preprint / Working Paper
Taylor, C. J. L., Renström, J. G., Loayza, J., Gwilt, M., Williams, S. A., Grasmeder Allen, R., Moran, P. M., Gigg, J., Neill, J., Harte, M., & Bast, T. (2025). Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats

Impaired GABAergic inhibition, so-called neural disinhibition, in the prefrontal cortex and hippocampus has been linked to cognitive deficits. The novel object recognition (NOR) task has been used widely to study cognitive deficits in rodents. Howeve... Read More about Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats.

Neuro-behavioral impact of Tourette-related striatal disinhibition in rats (2025)
Preprint / Working Paper
Loayza, J., Taylor, C., Renstrom, J., Grasmeder Allen, R., Jackson, S., & Bast, T. (2025). Neuro-behavioral impact of Tourette-related striatal disinhibition in rats

Tourette syndrome has been linked to reduced GABAergic inhibition, so called neural disinhibition, in the dorsal striatum. Dorsal-striatal neural disinhibition in animal models, caused by local microinfusion of GABA-A-receptor antagonists, produces s... Read More about Neuro-behavioral impact of Tourette-related striatal disinhibition in rats.

Tracking subjects' strategies in behavioural choice experiments at trial resolution. (2024)
Journal Article
Maggi, S., Hock, R. M., O'Neill, M., Buckley, M. J., Moran, P. M., Bast, T., Sami, M., & Humphries, M. D. (2024). Tracking subjects' strategies in behavioural choice experiments at trial resolution. eLife, 13, Article e86491. https://doi.org/10.7554/eLife.86491

Investigating how, when, and what subjects learn during decision-making tasks requires tracking their choice strategies on a trial-by-trial basis. Here we present a simple but effective probabilistic approach to tracking choice strategies at trial re... Read More about Tracking subjects' strategies in behavioural choice experiments at trial resolution..

Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro-behavioral mechanisms of reversal learning (2023)
Journal Article
Bast, T., Maggi, S., Grasmeder Allen, R., & Renstrom, J. (2023). Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro-behavioral mechanisms of reversal learning. Genes, Brain and Behavior, 22(6), Article e12870. https://doi.org/10.1111/gbb.12870

In this issue, Griesius et al report that heterozygous Dlg2+/- rats showed a reversal learning impairment on a specific bowl-digging task, whereas other reversal tasks were unaffected. The study suggests that Dlg2 gene disruption, which has been link... Read More about Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro-behavioral mechanisms of reversal learning.

Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear (2023)
Journal Article
Stubbendorff, C., Hale, E., Bast, T., Cassaday, H. J., Martin, S. J., Suwansawang, S., Halliday, D. M., & Stevenson, C. W. (2023). Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear. Scientific Reports, 13, Article 17631. https://doi.org/10.1038/s41598-023-44772-6

Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear. Dopamine D1-l... Read More about Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear.

Improving Translational Relevance in Preclinical Psychopharmacology (iTRIPP) (2023)
Journal Article
Bailey, S. J., Bast, T., Chaby, L., Kinon, B. J., Harte, M. K., Mead, S., Moloney, R. D., Ragan, I., Stanford, S. C., Tricklebank, M. D., Zervas, M., & Ajram, L. A. (2023). Improving Translational Relevance in Preclinical Psychopharmacology (iTRIPP). Journal of Psychopharmacology, 37(11), 1051-1057. https://doi.org/10.1177/02698811231182607

Animal models are important in preclinical psychopharmacology to study mechanisms and potential treatments for psychiatric disorders. A working group of 14 volunteers, comprising an international team of researchers from academia and industry, conven... Read More about Improving Translational Relevance in Preclinical Psychopharmacology (iTRIPP).

Heading Frequency and Risk of Cognitive Impairment in Retired Male Professional Soccer Players (2023)
Journal Article
Espahbodi, S., Hogervorst, E., Macnab, T.-M. P., Thanoon, A., Fernandes, G. S., Millar, B., Duncan, A., Goodwin, M., Batt, M., Fuller, C. W., Fuller, G., Ferguson, E., Bast, T., Doherty, M., & Zhang, W. (2023). Heading Frequency and Risk of Cognitive Impairment in Retired Male Professional Soccer Players. JAMA Network Open, 6(7), Article e2323822. https://doi.org/10.1001/jamanetworkopen.2023.23822

Importance Although professional soccer players appear to be at higher risk of neurodegenerative disease, the reason remains unknown.

Objective To examine whether heading frequency is associated with risk of cognitive impairment in retired profe... Read More about Heading Frequency and Risk of Cognitive Impairment in Retired Male Professional Soccer Players.

Cognitive Impairment and Self-Reported Dementia in UK Retired Professional Soccer Players: A Cross Sectional Comparative Study (2023)
Journal Article
Macnab, T.-M. P., Espahbodi, S., Hogervorst, E., Thanoon, A., Fernandes, G. S., Millar, B., Duncan, A., Goodwin, M., Batt, M., Fuller, C. W., Fuller, G., Ferguson, E., Bast, T., Doherty, M., & Zhang, W. (2023). Cognitive Impairment and Self-Reported Dementia in UK Retired Professional Soccer Players: A Cross Sectional Comparative Study. Sports Medicine - Open, 9, Article 43. https://doi.org/10.1186/s40798-023-00588-2

Background
Previous studies based on death certificates have found professional soccer players were more likely to die with neurodegenerative diseases, including dementia. Therefore, this study aimed to investigate whether retired professional male... Read More about Cognitive Impairment and Self-Reported Dementia in UK Retired Professional Soccer Players: A Cross Sectional Comparative Study.

No Evidence for Cognitive Impairment in an Experimental Rat Model of Knee Osteoarthritis and Associated Chronic Pain (2023)
Journal Article
Gonçalves, S., Hathway, G. J., Woodhams, S. G., Chapman, V., & Bast, T. (2023). No Evidence for Cognitive Impairment in an Experimental Rat Model of Knee Osteoarthritis and Associated Chronic Pain. Journal of Pain, 24(8), 1478-1492. https://doi.org/10.1016/j.jpain.2023.04.002

Although chronic pain states have been associated with impaired cognitive functions, including memory and cognitive flexibility, the cognitive effects of osteoarthritis (OA) pain remain to be clarified. The aim of this study was to measure cognitive... Read More about No Evidence for Cognitive Impairment in an Experimental Rat Model of Knee Osteoarthritis and Associated Chronic Pain.

Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls (2022)
Journal Article
Espahbodi, S., Fernandes, G., Hogervorst, E., Thanoon, A., Batt, M., Fuller, C. W., Fuller, G., Ferguson, E., Bast, T., Doherty, M., & Zhang, W. (2022). Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls. BMJ Open, 12(4), Article e054371. https://doi.org/10.1136/bmjopen-2021-054371

INTRODUCTION: Professional footballers commonly experience sports-related injury and repetitive microtrauma to the foot and ankle, placing them at risk of subsequent chronic pain and osteoarthritis (OA) of the foot and ankle. Similarly, repeated head... Read More about Foot and ankle Osteoarthritis and Cognitive impairment in retired UK Soccer players (FOCUS): protocol for a cross-sectional comparative study with general population controls.