Outputs (24)

Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study (2024)
Journal Article
Wilkinson-Smith, V., Scott, M., Menys, A., Wiklendt, L., MARCIANI, L., Atkinson, D., Sansone, S., Zdanavciene, A., Coupland, C., Knowles, C., Dinning, P., Taylor, S., Gowland, P., Hoad, C., Corsetti, M., & Spiller, R. (2025). Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study. Gut, 74(1), 35-44. https://doi.org/10.1136/gutjnl-2024-332755

Background
Colonic motility in constipation can be assessed non-invasively using MRI.

Objective
To compare MRI with high resolution colonic manometry (HRCM) for predicting treatment response.

Design
Part 1: 44 healthy volunteers (HV), 43... Read More about Combined magnetic resonance imaging, high resolution manometry and a randomised trial of bisacodyl versus hyoscine shows the significance of an enlarged colon in constipation: the RECLAIM study.

Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach (2023)
Journal Article
Nweze, T., Banaschewski, T., Ajaelu, C., Okoye, C., Ezenwa, M., Whelan, R., Papadopoulos Orfanos, D., Bokde, A. L., Desrivières, S., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J., Martinot, M. P., Artiges, E., Nees, F., Paus, T., Poustka, L., …IMAGEN Consortium. (2023). Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach. Journal of Child Psychology and Psychiatry, 64(8), 1159-1175. https://doi.org/10.1111/jcpp.13793

Background: Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferen... Read More about Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach.

Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use (2022)
Journal Article
Perkins, E. R., Joyner, K. J., Foell, J., Drislane, L. E., Brislin, S. J., Frick, P. J., Yancey, J. R., Soto, E. F., Ganley, C. M., Keel, P. K., Sica, C., Flor, H., Nees, F., Banaschewski, T., Bokde, A. L. W., Quinlan, E. B., Desrivières, S., Grigis, A., Garavan, H., Gowland, P., …Consortium, T. I. (2022). Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use. Journal of Psychopathology and Clinical Science, 131(7), 793-807. https://doi.org/10.1037/abn0000743

This study explored the generality versus specificity of two trait-liability factors for externalizing problems — disinhibition and callousness — in the concurrent and prospective prediction of symptoms of conduct disorder, attention-deficit/hyperact... Read More about Assessing General Versus Specific Liability for Externalizing Problems in Adolescence: Concurrent and Prospective Prediction of Symptoms of Conduct Disorder, ADHD, and Substance Use.

Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence (2022)
Journal Article
Nees, F., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Grigis, A., Garavan, H., Gowland, P., Grimmer, Y., Heinz, A., Brühl, R., Isensee, C., Becker, A., Martinot, J. L., Paillère Martinot, M. L., Artiges, E., Papadopoulos Orfanos, D., Lemaître, H., Stringaris, A., van Noort, B., Paus, T., …on behalf of the IMAGEN Consortium. (2022). Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence. Brain Sciences, 12(9), Article 1187. https://doi.org/10.3390/brainsci12091187

Background: Autistic traits are commonly viewed as dimensional in nature, and as continuously distributed in the general population. In this respect, the identification of predictive values of markers such as subtle autism-related alterations in brai... Read More about Global and Regional Structural Differences and Prediction of Autistic Traits during Adolescence.

A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood (2022)
Journal Article
Kaiser, A., Holz, N. E., Banaschewski, T., Baumeister, S., Bokde, A. L. W., Desrivières, S., Flor, H., Fröhner, J. H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Martinot, M.-L. P., Artiges, E., Millenet, S., Orfanos, D. P., Poustka, L., Schwarz, E., …Nees, F. (2022). A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(11), 1103-1115. https://doi.org/10.1016/j.bpsc.2022.02.003

Background: On a theoretical level, impulsivity represents a multidimensional construct associated with acting without foresight, inefficient inhibitory response control, and alterations in reward processing. On an empirical level, relationships and... Read More about A Developmental Perspective on Facets of Impulsivity and Brain Activity Correlates From Adolescence to Adulthood.

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article
Alyami, A., Hoad, C. L., Tench, C., Bannur, U., Clarke, C., Latief, K., Argyriou, K., Lobo, A., Lung, P., Baldwin-Cleland, R., Sahnan, K., Hart, A., Limdi, J. K., McLaughlin, J., Atkinson, D., Parker, G. J. M., O’Connor, J. P. B., Little, R. A., Gowland, P. A., & Moran, G. W. (2021). Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study. Diagnostics, 11(11), Article 2135. https://doi.org/10.3390/diagnostics11112135

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.

Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies (2021)
Journal Article
Gunn, D., Abbas, Z., Harris, H., Major, G., Hoad, C., Gowland, P., Marciani, L., Gill, S., Warren, F., Rossi, M., Remes-Troche, J., Whelan, K., & Spiller, R. (2022). Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies. Gut, 71(5), 919-927. https://doi.org/10.1136/gutjnl-2021-324784

Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would reduce gas... Read More about Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies.

Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI (2021)
Journal Article
Sharif, H., Hoad, C. L., Abrehart, N., Gowland, P. A., Spiller, R. C., Kirkham, S., Loganathan, S., Papadopoulos, M., Benninga, M. A., Devadason, D., & Marciani, L. (2021). Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI. Diagnostics, 11(6), Article 974. https://doi.org/10.3390/diagnostics11060974

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provid... Read More about Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.

Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts (2021)
Journal Article
Elkrief, L., Spinney, S., Vosberg, D. E., Banaschewski, T., Bokde, A., Quinlan, E. B., Desrivières, S., Flor, H., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J. .-L., Martinot, M.-L. P., Nees, F., Orfanos, D. P., Poustka, L., Hohmann, S., Millenet, S. K., Fröhner, J. H., …Conrod, P. (2021). Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts. Frontiers in Psychiatry, 12, Article 645746. https://doi.org/10.3389/fpsyt.2021.645746

Genetic markers of endocannabinoid system have been linked to a variety of addiction-related behaviours that extend beyond cannabis use. In the current study we investigate the relationship between eCB genetic markers and AUDs in European adolescents... Read More about Endocannabinoid Gene x Gene Interaction Association to Alcohol Use Disorder in two Adolescent Cohorts.

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article
Scott, R. A., Williams, H. G., Hoad, C. L., Alyami, A., Ortori, C. A., Grove, J. I., Marciani, L., Moran, G. W., Spiller, R. C., Menys, A., Aithal, G. P., & Gowland, P. A. (2021). MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability. Journal of Magnetic Resonance Imaging, 53(5), 1422-1431. https://doi.org/10.1002/jmri.27463

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.