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Outputs (10)

Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study (2020)
Journal Article
Briley, P. M., Liddle, E. B., Simmonite, M., Jansen, M., White, T. P., Balain, V., Palaniyappan, L., Bowtell, R., Mullinger, K. J., & Liddle, P. F. (2021). Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(12), 1145-1156. https://doi.org/10.1016/j.bpsc.2020.10.018

Background: There is emerging evidence for abnormal beta oscillations in psychosis. Beta oscillations are likely to play a key role in the coordination of sensorimotor information that is crucial to healthy mental function. Growing evidence suggests... Read More about Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study.

Quantifying the core deficit in classical schizophrenia (2020)
Journal Article
Rathnaiah, M., Liddle, E., Gascoyne, L., Kumar, J., Zia Ul Haq Katshu, M., Faruqi, C., Kelly, C., Gill, M., Robson, S., Brookes, M., Palaniyappan, L., Morris, P., & Liddle, P. F. (2020). Quantifying the core deficit in classical schizophrenia. Schizophrenia Bulletin Open, 1(1), Article sgaa031. https://doi.org/10.1093/schizbullopen/sgaa031

In the classical descriptions of schizophrenia, Kraepelin and Bleuler recognised disorganization and impoverishment of mental activity as fundamental symptoms. Their classical descriptions also included a tendency to persisting disability. The psycho... Read More about Quantifying the core deficit in classical schizophrenia.

Development of human electrophysiological brain networks (2018)
Journal Article
Briley, P. M., Liddle, E. B., Groom, M. J., Smith, H. J. F., Morris, P. G., Colclough, G. L., Brookes, M. J., & Liddle, P. F. (2018). Development of human electrophysiological brain networks. Journal of Neurophysiology, 120(6), 3122-3130. https://doi.org/10.1152/jn.00293.2018

Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the default mode network (DMN), whic... Read More about Development of human electrophysiological brain networks.

Attenuated post-movement beta rebound associated with schizotypal features in healthy people (2018)
Journal Article
Hunt, B. A., Liddle, E. B., Gascoyne, L. E., Magazzini, L., Routley, B. C., Singh, K. D., Morris, P. G., Brookes, M. J., & Liddle, P. F. (2019). Attenuated post-movement beta rebound associated with schizotypal features in healthy people. Schizophrenia Bulletin, 45(4), 883-891. https://doi.org/10.1093/schbul/sby117

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. Introduction: Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidenc... Read More about Attenuated post-movement beta rebound associated with schizotypal features in healthy people.

Changes in electrophysiological markers of cognitive control after administration of galantamine (2018)
Journal Article
Robson, S. E., Gascoyne, L. E., Mullinger, K. J., Robson, S., Kumar, J., O'Neill, G. C., Palaniyappan, L., Morris, P. G., Liddle, E. B., Brookes, M. J., & Liddle, P. F. (2018). Changes in electrophysiological markers of cognitive control after administration of galantamine. NeuroImage: Clinical, 20, 228-235. https://doi.org/10.1016/j.nicl.2018.07.019

© 2018 The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to sym... Read More about Changes in electrophysiological markers of cognitive control after administration of galantamine.

Glutathione and glutamate in schizophrenia: a 7T MRS study (2018)
Journal Article
Kumar, J., Liddle, E. B., Fernandes, C. C., Palaniyappan, L., Hall, E. L., Robson, S. E., Simmonite, M., Fiesal, J., Katshu, M. Z., Qureshi, A., Skelton, M., Christodoulou, N. G., Brookes, M. J., Morris, P. G., & Liddle, P. F. (2018). Glutathione and glutamate in schizophrenia: a 7T MRS study. Molecular Psychiatry, 25(4), 873–882. https://doi.org/10.1038/s41380-018-0104-7

© 2018 The Author(s) In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage following neuroinflammatory processes implicated in acute episodes. Inflammation is associated with increased glutamate, whereas the antio... Read More about Glutathione and glutamate in schizophrenia: a 7T MRS study.

Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment (2018)
Journal Article
Brookes, M. J., Groom, M. J., Liuzzi, L., Hill, R. M., Smith, H. J., Briley, P. M., Hall, E. L., Hunt, B. A., Gascoyne, L. E., Taylor, M. J., Liddle, P. F., Morris, P. G., Woolrich, M. W., & Liddle, E. B. (2018). Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment. NeuroImage, 174, https://doi.org/10.1016/j.neuroimage.2018.03.008

Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investig... Read More about Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment.

A multi-layer network approach to MEG connectivity analysis (2016)
Journal Article
Brookes, M. J., Tewarie, P. K., Hunt, B. A. E., Robson, S. E., Gascoyne, L. E., Liddle, E. B., Liddle, P. F., & Morris, P. G. (2016). A multi-layer network approach to MEG connectivity analysis. NeuroImage, 132, 425-438. https://doi.org/10.1016/j.neuroimage.2016.02.045

© 2016 The Authors. Recent years have shown the critical importance of inter-regional neural network connectivity in supporting healthy brain function. Such connectivity is measurable using neuroimaging techniques such as MEG, however the richness of... Read More about A multi-layer network approach to MEG connectivity analysis.

Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia (2016)
Journal Article
Liddle, E. B., Price, D., Palaniyappan, L., Brookes, M. J., Robson, S. E., Hall, E. L., Morris, P. G., & Liddle, P. F. (2016). Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia. Human Brain Mapping, 37(4), 1361-1374. https://doi.org/10.1002/hbm.23107

Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, e... Read More about Abnormal salience signaling in schizophrenia: The role of integrative beta oscillations: Salience Signaling in Schizophrenia.