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The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG (2015)
Journal Article
Croal, P. L., Hall, E. L., Driver, I. D., Brookes, M. J., Gowland, P. A., & Francis, S. T. (2015). The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG. NeuroImage, 105, https://doi.org/10.1016/j.neuroimage.2014.10.036

The physiological effect of hyperoxia has been poorly characterised, with studies reporting conflicting results on the role of hyperoxia as a vasoconstrictor. It is not clear whether hyperoxia is the primary contributor to vasoconstriction or whether... Read More about The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG.

Neural and Cognitive Correlates of the Common and Specific Variance Across Externalizing Problems in Young Adolescence (2014)
Journal Article
Castellanos-Ryan, N., Struve, M., Whelan, R., Banaschewski, T., Barker, G., Bokde, A., Bromberg, U., Büchel, C., Flor, H., Fauth-Bühler, M., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Lawrence, C., Martinot, J.-L., Nees, F., Paus, T., Pausova, Z., Rietschel, M., …Conrod, P. (2014). Neural and Cognitive Correlates of the Common and Specific Variance Across Externalizing Problems in Young Adolescence. American Journal of Psychiatry, 171(12), 1310-1319. https://doi.org/10.1176/appi.ajp.2014.13111499

Neuropsychosocial profiles of current and future adolescent alcohol misusers (2014)
Journal Article
Whelan, R., Watts, R., Orr, C. A., Althoff, R. R., Artiges, E., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Carvalho, F. M., Conrod, P. J., Flor, H., Fauth-Bühler, M., Frouin, V., Gallinat, J., Gan, G., Gowland, P., Heinz, A., Ittermann, B., Lawrence, C., …Ziesch, V. (2014). Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature, 512(7513), 185-189. https://doi.org/10.1038/nature13402

A comprehensive account of the causes of alcohol misuse must accommodate individual differences in biology, psychology and environment, and must disentangle cause and effect. Animal models can demonstrate the effects of neurotoxic substances; however... Read More about Neuropsychosocial profiles of current and future adolescent alcohol misusers.

Effectiveness of 0.05% oxymetazoline (Vicks Sinex Micromist) nasal spray in the treatment of objective nasal congestion demonstrated to 12h post-administration by magnetic resonance imaging (2014)
Journal Article
Pritchard, S. E., Glover, M., Guthrie, G., Brum, J., Ramsey, D., Kappler, G., Thomas, P., Stuart, S., Hull, D., & Gowland, P. A. (2014). Effectiveness of 0.05% oxymetazoline (Vicks Sinex Micromist) nasal spray in the treatment of objective nasal congestion demonstrated to 12h post-administration by magnetic resonance imaging. Pulmonary Pharmacology and Therapeutics, 27(1), https://doi.org/10.1016/j.pupt.2013.08.002

Introduction: This study aimed to assess the qualitative and quantitative utility of MRI imaging to illustrate the magnitude and duration of the effect of a standard 100 μg dose of oxymetazoline in a commercially available formulation that also conta... Read More about Effectiveness of 0.05% oxymetazoline (Vicks Sinex Micromist) nasal spray in the treatment of objective nasal congestion demonstrated to 12h post-administration by magnetic resonance imaging.

The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T (2014)
Journal Article
Schwarz, S., Afzal, M., Morgan, P., Auer, D., Bajaj, N., & Gowland, P. A. (2014). The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T. PLoS ONE, 9(4), Article e93814. https://doi.org/10.1371/journal.pone.0093814

There is no well-established in vivo marker of nigral degeneration in Parkinson's disease (PD). An ideal imaging marker would directly mirror the loss of substantia nigra dopaminergic neurones, which is most prominent in sub-regions called nigrosomes... Read More about The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T.

Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects (2013)
Journal Article
Chaddock, G., Lam, C., Hoad, C., Costigan, C., Cox, E. F., Placidi, E., Thexton, I., Wright, J., Blackshaw, P. E., Perkins, A. C., Marciani, L., Gowland, P. A., & Spiller, R. C. (2014). Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects. Neurogastroenterology and Motility, 26(2), 205-214. https://doi.org/10.1111/nmo.12249

Background: Colonic transit tests are used to manage patients with Functional Gastrointestinal Disorders. Some tests used expose patients to ionizing radiation. The aim of this study was to compare novel magnetic resonance imaging (MRI) tests for mea... Read More about Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects.

Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study (2013)
Journal Article
Anblagan, D., Jones, N. W., Costigan, C., Parker, A. J., Allcock, K., Aleong, R., Coyne, L. H., Deshpande, R., Raine-Fenning, N., Bugg, G., Roberts, N., Pausova, Z., Paus, T., & Gowland, P. A. (2013). Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study. PLoS ONE, 8(6), Article e67223. https://doi.org/10.1371/journal.pone.0067223

Objective: To study whether maternal cigarette smoking during pregnancy is associated with alterations in the growth of
fetal lungs, kidneys, liver, brain, and placenta.
Design: A case-control study, with operators performing the image analysis bli... Read More about Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study.

Regional structural differences across functionally parcellated Brodmann areas of human primary somatosensory cortex (2013)
Journal Article
Sánchez-Panchuelo, R.-M., Besle, J., Mougin, O., Gowland, P., Bowtell, R., Schluppeck, D., & Francis, S. (2014). Regional structural differences across functionally parcellated Brodmann areas of human primary somatosensory cortex. NeuroImage, 93 Pt 2, 221-230. https://doi.org/10.1016/j.neuroimage.2013.03.044

Ultra-high-field (UHF) MRI is ideally suited for structural and functional imaging of the brain. High-resolution structural MRI can be used to map the anatomical boundaries between functional domains of the brain by identifying changes related to the... Read More about Regional structural differences across functionally parcellated Brodmann areas of human primary somatosensory cortex.

Effects of various food ingredients on gall bladder emptying (2013)
Journal Article
Marciani, L., Cox, E., Hoad, C., Totman, J. J., Costigan, C., Singh, G., Shepherd, V., Chalkley, L., Robinson, M., Ison, R., Gowland, P. A., & Spiller, R. C. (2013). Effects of various food ingredients on gall bladder emptying. European Journal of Clinical Nutrition, 67(11), https://doi.org/10.1038/ejcn.2013.168

Background/objectives: The emptying of the gall bladder in response to feeding is pivotal for the digestion of fat, but the role of various food ingredients in contracting the gall bladder postprandially is not well understood. We hypothesized that d... Read More about Effects of various food ingredients on gall bladder emptying.