Susan Elizabeth Pritchard
Effectiveness of 0.05% oxymetazoline (Vicks Sinex Micromist) nasal spray in the treatment of objective nasal congestion demonstrated to 12h post-administration by magnetic resonance imaging
Pritchard, Susan Elizabeth; Glover, Mark; Guthrie, Graeme; Brum, Jose; Ramsey, D.; Kappler, Gail; Thomas, Peter; Stuart, S.; Hull, D.; Gowland, Penny A.
Authors
Mark Glover
Graeme Guthrie
Jose Brum
D. Ramsey
Gail Kappler
Peter Thomas
S. Stuart
D. Hull
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Abstract
Introduction: This study aimed to assess the qualitative and quantitative utility of MRI imaging to illustrate the magnitude and duration of the effect of a standard 100 ?g dose of oxymetazoline in a commercially available formulation that also contains aromatic oils.
Methods: This was a randomized, open label, single dose, parallel group study in 21 adult male and female subjects who reported moderate to severe nasal congestion due to acute upper respiratory tract infection or hay fever. MRI scans were acquired using a 3T Philips Achieva scanner with a 16 channel head receive coil. High resolution MRI scans of the nasal turbinates were obtained immediately prior to dosing (baseline) and at approximately 1, 8, 10, 11, and 12 hours after dosing. The efficacy variables of primary interest were inferior turbinate total volume at 8 and 12 hours post-dosing. The secondary efficacy variables analysed were inferior turbinate total volume at 1, 10, and 11 hours post-dosing, middle turbinate total volume at 1, 8, 10, 11, and 12 hours post-dosing.
Results: Changes from baseline volumes measured for the inferior and middle turbinates of subjects receiving the oxymetazoline formulation showed significant (P
Citation
Pritchard, S. E., Glover, M., Guthrie, G., Brum, J., Ramsey, D., Kappler, G., …Gowland, P. A. (2014). Effectiveness of 0.05% oxymetazoline (Vicks Sinex Micromist) nasal spray in the treatment of objective nasal congestion demonstrated to 12h post-administration by magnetic resonance imaging. Pulmonary Pharmacology and Therapeutics, 27(1), https://doi.org/10.1016/j.pupt.2013.08.002
Journal Article Type | Article |
---|---|
Publication Date | Feb 1, 2014 |
Deposit Date | Feb 4, 2016 |
Publicly Available Date | Feb 4, 2016 |
Journal | Pulmonary Pharmacology & Therapeutics |
Electronic ISSN | 1522-9629 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 27 |
Issue | 1 |
DOI | https://doi.org/10.1016/j.pupt.2013.08.002 |
Keywords | Oxymetazoline, Long-Lasting, Nasal Turbinates, MRI, Volume Measurement |
Public URL | https://nottingham-repository.worktribe.com/output/997191 |
Publisher URL | http://www.sciencedirect.com/science/article/pii/S1094553913001673 |
Related Public URLs | http://authors.elsevier.com/sd/article/S1094553913001673 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
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