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A multiphase multiscale model for nutrient limited tissue growth (2018)
Journal Article
Holden, E., Collis, J., Brook, B. S., & O'Dea, R. D. (2018). A multiphase multiscale model for nutrient limited tissue growth. ANZIAM Journal, 59(4), https://doi.org/10.1017/S1446181118000044

In this work, an effective macroscale description is derived for the growth of tissue on a porous scaffold. A multiphase model is employed to describe the tissue dynamics; linearisation to facilitate a multiple-scale homogenisation provides an effect... Read More about A multiphase multiscale model for nutrient limited tissue growth.

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss (2018)
Journal Article
Chernyavsky, I. L., Russell, R. J., Saunders, R. M., Morris, G. E., Berair, R., Singapuri, A., Chachi, L., Mansur, A. H., Howarth, P. H., Dennison, P., Chaudhuri, R., Bicknell, S., Rose, F. R. A., Siddiqui, S., Brook, B. S., & Brightling, C. E. (2018). In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss. European Respiratory Journal, 51(5), Article 1701680. https://doi.org/10.1183/13993003.01680-2017

Bronchial thermoplasty is a treatment for asthma. Whether during thermoplasty the airway wall fraction exposed to temperatures necessary to affect cells is sufficient to explain its histopathological impact is unclear.
Airway smooth muscle and bronc... Read More about In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.

A multiphase multiscale model for nutrient limited tissue growth (2017)
Journal Article
Holden, E. C., Collis, J., Brook, B. S., & O'Dea, R. D. (2017). A multiphase multiscale model for nutrient limited tissue growth. ANZIAM Journal, 59, 499-532. https://doi.org/10.21914/anziamj.v59i0.12240

We derive an effective macroscale description for the growth of tissue on a porous scaffold. A multiphase model is employed to describe the tissue dynamics; linearisation to facilitate a multiple-scale homogenisation provides an effective macroscale... Read More about A multiphase multiscale model for nutrient limited tissue growth.

A novel computational model predicts key regulators of chemokine gradient formation in lymph nodes and site-specific roles for CCL19 and ACKR4 (2017)
Journal Article
Jafarnejad, M., Zawieja, D. C., Brook, B. S., Nibbs, R. J., & Moore, J. E. (2017). A novel computational model predicts key regulators of chemokine gradient formation in lymph nodes and site-specific roles for CCL19 and ACKR4. Journal of Immunology, 199(7), 2291-2304. https://doi.org/10.4049/jimmunol.1700377

The chemokine receptor CCR7 drives leukocyte migration into and within lymph nodes (LNs). It is activated by chemokines CCL19 and CCL21, which are scavenged by the atypical chemokine receptor ACKR4. CCR7-dependent navigation is determined by the dist... Read More about A novel computational model predicts key regulators of chemokine gradient formation in lymph nodes and site-specific roles for CCL19 and ACKR4.

Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage (2017)
Journal Article
Baker, M., Brook, B. S., & Owen, M. R. (2017). Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage. Journal of Mathematical Biology, 75(4), 985-1024. https://doi.org/10.1007/s00285-017-1104-y

Osteoarthritis (OA) is a degenerative disease which causes pain and stiffness in joints. OA progresses through excessive degradation of joint cartilage, eventually leading to significant joint degeneration and loss of function. Cytokines, a group of... Read More about Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage.

Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice (2016)
Journal Article
Hiorns, J. E., Bidan, C. M., Jensen, O. E., Gosens, R., Kistemaker, L. E., Fredberg, J. J., Butler, J. P., Krishnan, R., & Brook, B. S. (2016). Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice. Frontiers in Physiology, 7(JUL), Article 309. https://doi.org/10.3389/fphys.2016.00309

The precision-cut lung slice (PCLS) is a powerful tool for studying airway reactivity, but biomechanical measurements to date have largely focused on changes in airway caliber. Here we describe an image processing tool that reveals the associated spa... Read More about Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.

Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall (2016)
Journal Article
Hiorns, J. E., Jensen, O. E., & Brook, B. S. (2016). Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall. Journal of Applied Physiology, 121(1), 233-247. https://doi.org/10.1152/japplphysiol.00715.2015

Airway hyperresponsiveness (AHR) is a key characteristic of asthma that remains poorly understood. Tidal breathing and deep inspiration ordinarily cause rapid relaxation of airway smooth muscle (ASM) (as demonstrated via application of length fluctua... Read More about Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall.