Outputs (14)

Long-term survival after adult epilepsy surgery: mortality and predictors in a large cohort (2025)
Journal Article
Fiore, G., de Tisi, J., O'Keeffe, A., Miserocchi, A., McEvoy, A. W., Sander, J. W., & Duncan, J. S. (2025). Long-term survival after adult epilepsy surgery: mortality and predictors in a large cohort. Epilepsia, https://doi.org/10.1111/epi.18564

Objective

Long-term survival data in adults undergoing surgery for drug-resistant focal epilepsy remain limited. We examined mortality patterns and predictors in a large cohort followed for over 30 years.

Methods

Adults who underwent epileps... Read More about Long-term survival after adult epilepsy surgery: mortality and predictors in a large cohort.

The START (STrAtegies for RelaTives) Intervention for Family Carers of People With Dementia: Evaluation, Statistical Challenges and Impact (2025)
Book Chapter
Barber, J. A., O’Keeffe, A. G., & Livingston, G. (2025). The START (STrAtegies for RelaTives) Intervention for Family Carers of People With Dementia: Evaluation, Statistical Challenges and Impact. In P. J. Aston (Ed.), More UK Success Stories in Industrial Mathematics (113-119). Springer. https://doi.org/10.1007/978-3-031-48683-8_15

The STrAtegies for RelaTives (START) intervention is a psychological therapy to reduce anxiety and depression in family carers of people with dementia living in the community. It was developed and evaluated, using a randomised controlled trial, by a... Read More about The START (STrAtegies for RelaTives) Intervention for Family Carers of People With Dementia: Evaluation, Statistical Challenges and Impact.

Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning (2025)
Journal Article
Dasgupta, D., Elliott, C. A., O’Keeffe, A. G., Rodionov, R., Li, K., Vakharia, V. N., Mirza, F. A., Tahir, M. Z., Tisdall, M. M., Miserocchi, A., McEvoy, A. W., Ourselin, S., Sparks, R. E., & Duncan, J. S. (2025). Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning. Frontiers in Neurology, 16, Article 1514442. https://doi.org/10.3389/fneur.2025.1514442

Objectives: This study aims to refine computer-assisted planning (CAP) of SEEG implantations by adding spatial constraints from prior SEEG trajectories (“Priors”) to improve safety and reduce manual adjustments, without increasing planning time. Meth... Read More about Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning.

Evaluating a model of best practice in primary care led post-diagnostic dementia care: feasibility and acceptability findings from the PriDem study (2024)
Journal Article
Griffiths, S., Spencer, E., Flanagan, K., O'Keeffe, A., Hunter, R., Wiegand, M., D'Andrea, F., Benjamin, L., Poole, M., Hagan, A. J., Brar, M., Wilcock, J., Walters, K. R., Robinson, L., & Rait, G. (2024). Evaluating a model of best practice in primary care led post-diagnostic dementia care: feasibility and acceptability findings from the PriDem study. BMJ Open, 14(7), Article e083175. https://doi.org/10.1136/bmjopen-2023-083175

Objectives: To evaluate the feasibility and acceptability of a primary care-based intervention for improving post-diagnostic dementia care and support (PriDem), and implementation study procedures. Design: A non-randomised, mixed methods, feasibility... Read More about Evaluating a model of best practice in primary care led post-diagnostic dementia care: feasibility and acceptability findings from the PriDem study.

Access to personalised dementia care planning in primary care: a mixed methods evaluation of the PriDem intervention (2024)
Journal Article
Spencer, E., Griffiths, S., Flanagan, K., O'Keeffe, A., Wiegand, M., Benjamin, L., D'Andrea, F., Wilcock, J., Poole, M., Walters, K. R., Robinson, L., & Rait, G. (2024). Access to personalised dementia care planning in primary care: a mixed methods evaluation of the PriDem intervention. BMJ Open, 14(7), Article e082083. https://doi.org/10.1136/bmjopen-2023-082083

Objectives: Provision of personalised care planning is a national priority for people with dementia. Research suggests a lack of quality and consistency of care plans and reviews. The PriDem model of care was developed to deliver feasible and accepta... Read More about Access to personalised dementia care planning in primary care: a mixed methods evaluation of the PriDem intervention.

Approaches to risk ratio estimation in a regression discontinuity design: Application to the prescription of statins for cholesterol reduction in UK primary care (2023)
Journal Article
Adeleke, M. O., O’Keeffe, A. G., & Baio, G. (2023). Approaches to risk ratio estimation in a regression discontinuity design: Application to the prescription of statins for cholesterol reduction in UK primary care. Statistical Methods in Medical Research, 32(10), 1994-2015. https://doi.org/10.1177/09622802231192958

In recent years regression discontinuity designs have been used increasingly for the estimation of treatment effects in observational medical data where a rule-based decision to apply treatment is taken using a continuous assignment variable. Most re... Read More about Approaches to risk ratio estimation in a regression discontinuity design: Application to the prescription of statins for cholesterol reduction in UK primary care.

The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change. (2023)
Journal Article
Peter Binding, L., Neal Taylor, P., O'Keeffe, A. G., Giampiccolo, D., Fleury, M., Xiao, F., Caciagli, L., de Tisi, J., Winston, G. P., Miserocchi, A., McEvoy, A., Duncan, J. S., & Vos, S. B. (2023). The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change. NeuroImage: Clinical, 38, Article 103444. https://doi.org/10.1016/j.nicl.2023.103444

Background: Anterior temporal lobe resection (ATLR) is a successful treatment for medically-refractory temporal lobe epilepsy (TLE). In the language-dominant hemisphere, 30%- 50% of individuals experience a naming decline which can impact upon daily... Read More about The impact of temporal lobe epilepsy surgery on picture naming and its relationship to network metric change..

Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy (2023)
Journal Article
Binding, L. P., Dasgupta, D., Taylor, P. N., Thompson, P. J., O'Keeffe, A. G., De Tisi, J., Mcevoy, A. W., Miserocchi, A., Duncan, J. S., Duncan, J. S., & Vos, S. B. (2023). Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy. Neurology, 100(15), e1621-e1633. https://doi.org/10.1212/WNL.0000000000206862

Background and ObjectivesIn medically refractory temporal lobe epilepsy (TLE), 30%-50% of patients experience substantial language decline after resection in the language-dominant hemisphere. In this study, we investigated the contribution of white m... Read More about Contribution of White Matter Fiber Bundle Damage to Language Change After Surgery for Temporal Lobe Epilepsy.

Hippocampal resection in temporal lobe epilepsy: Do we need to resect the tail? (2023)
Journal Article
Dasgupta, D., Finn, R., Chari, A., Giampiccolo, D., de Tisi, J., O’Keeffe, A. G., Miserocchi, A., McEvoy, A. W., Vos, S. B., & Duncan, J. S. (2023). Hippocampal resection in temporal lobe epilepsy: Do we need to resect the tail?. Epilepsy Research, 190, Article 107086. https://doi.org/10.1016/j.eplepsyres.2023.107086

Introduction: Anteromesial temporal lobe resection is the most common surgical technique used to treat drug-resistant mesial temporal lobe epilepsy, particularly when secondary to hippocampal sclerosis. Structural and functional imaging data suggest... Read More about Hippocampal resection in temporal lobe epilepsy: Do we need to resect the tail?.

Long-term seizure, psychiatric and socioeconomic outcomes after frontal lobe epilepsy surgery (2022)
Journal Article
Khoo, A., de Tisi, J., Foong, J., Bindman, D., O'Keeffe, A. G., Sander, J. W., Miserocchi, A., McEvoy, A. W., & Duncan, J. S. (2022). Long-term seizure, psychiatric and socioeconomic outcomes after frontal lobe epilepsy surgery. Epilepsy Research, 186, Article 106998. https://doi.org/10.1016/j.eplepsyres.2022.106998

Objective: Resective surgery for selected individuals with frontal lobe epilepsy can be effective, although multimodal outcomes are less established than in temporal lobe epilepsy. We describe long-term seizure remission and relapse patterns, psychia... Read More about Long-term seizure, psychiatric and socioeconomic outcomes after frontal lobe epilepsy surgery.