Outputs (1786)

Comparative judgement modeling to map forced marriage at local levels (2025)
Journal Article
Seymour, R., Nyarko-Agyei, A., Mccabe, H., Severn, K., Sirl, D., Kypraios, T., & Taylor, A. (2025). Comparative judgement modeling to map forced marriage at local levels. Annals of Applied Statistics, 19(1), 419-439. https://doi.org/10.1214/24-AOAS1966

Forcing someone into marriage against their will is a violation of their human rights. In 2021, the county of Nottinghamshire, UK, launched a strategy to tackle forced marriage and violence against women and girls. We set out to map the risk of force... Read More about Comparative judgement modeling to map forced marriage at local levels.

Evaluating the predictive accuracy of ion-channel models using data from multiple experimental designs (2025)
Journal Article
Shuttleworth, J. G., Lei, C. L., Windley, M. J., Hill, A. P., Preston, S. P., & Mirams, G. R. (2025). Evaluating the predictive accuracy of ion-channel models using data from multiple experimental designs. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 383(2292), Article 20240211. https://doi.org/10.1098/rsta.2024.0211

Mathematical models are increasingly being relied upon to provide quantitatively accurate predictions of cardiac electrophysiology. Many such models concern the behaviour of particular subcellular components (namely, ion channels) which, together, al... Read More about Evaluating the predictive accuracy of ion-channel models using data from multiple experimental designs.

Optimizing experimental designs for model selection of ion channel drug-binding mechanisms (2025)
Journal Article
Patten-Elliott, F., Lei, C. L., Preston, S. P., Wilkinson, R. D., & Mirams, G. R. (2025). Optimizing experimental designs for model selection of ion channel drug-binding mechanisms. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 383(2292), https://doi.org/10.1098/rsta.2024.0227

The rapid delayed rectifier current carried by the human Ether-à-go-go-Related Gene (hERG) channel is susceptible to drug-induced reduction, which can lead to an increased risk of cardiac arrhythmia. Establishing the mechanism by which a specific dru... Read More about Optimizing experimental designs for model selection of ion channel drug-binding mechanisms.

Parameter inference for stochastic reaction models of ion channel gating from whole-cell voltage-clamp data (2025)
Journal Article
Del Core, L., & Mirams, G. R. (2025). Parameter inference for stochastic reaction models of ion channel gating from whole-cell voltage-clamp data. Philosophical Transactions A: Mathematical, Physical and Engineering Sciences, 383(2292), https://doi.org/10.1098/rsta.2024.0224

Mathematical models of ion channel gating describe the changes in ion channel configurations due to the electrical activity of the cell membrane. Experimental findings suggest that ion channels behave randomly, and therefore stochastic models of ion... Read More about Parameter inference for stochastic reaction models of ion channel gating from whole-cell voltage-clamp data.

Real-time inference for binary neutron star mergers using machine learning (2025)
Journal Article
Dax, M., R. Green, S., Gair, J., Gupte, N., Pürrer, M., Raymond, V., Wildberger, J., Macke, J. H., Buonanno, A., & Schölkopf, B. (2025). Real-time inference for binary neutron star mergers using machine learning. Nature, 639(8053), 49-53. https://doi.org/10.1038/s41586-025-08593-z

Mergers of binary neutron stars emit signals in both the gravitational-wave (GW) and electromagnetic spectra. Famously, the 2017 multi-messenger observation of GW170817 (refs. 1,2) led to scientific discoveries across cosmology3, nuclear physics4,5,6... Read More about Real-time inference for binary neutron star mergers using machine learning.

Kerr metric from two commuting complex structures (2025)
Journal Article
Krasnov, K., & Shaw, A. (2025). Kerr metric from two commuting complex structures. Classical and Quantum Gravity, 42(6), Article 065013. https://doi.org/10.1088/1361-6382/adb531

The main aim of this paper is to simplify and popularise the construction from the 2013 paper by Apostolov, Calderbank, and Gauduchon, which (among other things) derives the Pleba´nskiPleba´nski-Demia´nskiDemia´nski family of solutions of GR using id... Read More about Kerr metric from two commuting complex structures.

Comparison of in silico predictions of action potential duration in response to inhibition of IKrand ICaLwith new human ex vivo recordings (2025)
Preprint / Working Paper
Barral, Y.-S. H., Polonchuk, L., Clerx, M., Gavaghan, D. J., Mirams, G. R., & Wang, K. Comparison of in silico predictions of action potential duration in response to inhibition of IKrand ICaLwith new human ex vivo recordings

During drug development, candidate compounds are extensively tested for proar-rhythmic risk and in particular risk of Torsade de Pointes (TdP), as indicated by prolongation of the QT interval. Drugs that inhibit the rapid delayed rectifier K+ current... Read More about Comparison of in silico predictions of action potential duration in response to inhibition of IKrand ICaLwith new human ex vivo recordings.

Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning (2025)
Journal Article
Dasgupta, D., Elliott, C. A., O’Keeffe, A. G., Rodionov, R., Li, K., Vakharia, V. N., Mirza, F. A., Tahir, M. Z., Tisdall, M. M., Miserocchi, A., McEvoy, A. W., Ourselin, S., Sparks, R. E., & Duncan, J. S. (2025). Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning. Frontiers in Neurology, 16, Article 1514442. https://doi.org/10.3389/fneur.2025.1514442

Objectives
To refine computer-assisted planning (CAP) of SEEG implantations by adding constraints of prior spatial SEEG trajectories (‘Priors’) to improve safety, reduce manual adjustments required, without increasing planning time.

Methods
Retr... Read More about Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning.

Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait (2025)
Journal Article
Post, E., Van Laarhoven, T., Raykov, Y. P., Little, M. A., Nonnekes, J., Heskes, T. M., Bloem, B. R., & Evers, L. J. W. (2025). Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait. Journal of NeuroEngineering and Rehabilitation, 22(1), Article 37. https://doi.org/10.1186/s12984-025-01578-z

Background
Accurately measuring hypokinetic arm swing during free-living gait in Parkinson’s disease (PD) is challenging due to other concurrent arm activities. We developed a method to isolate gait segments without these arm activities.

Methods... Read More about Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait.

Understanding the regulation of chronic wounds by tissue inhibitors of matrix metalloproteinases through mathematical modelling (2025)
Journal Article
Dari, S., O'Dea, R. D., & Fadai, N. T. (2025). Understanding the regulation of chronic wounds by tissue inhibitors of matrix metalloproteinases through mathematical modelling. Journal of Theoretical Biology, 604, Article 112083. https://doi.org/10.1016/j.jtbi.2025.112083

Understanding the biochemistry and pharmacodynamics of chronic wounds is of key importance, due to the millions of people in the UK affected and the significant cost to the NHS. Chronic wounds are characterised by elevated concentrations of matrix me... Read More about Understanding the regulation of chronic wounds by tissue inhibitors of matrix metalloproteinases through mathematical modelling.