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Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping (2024)
Journal Article
Kyratzi, P., Matika, O., Brassington, A. H., Clare, C. E., Xu, J., Barrett, D. A., Emes, R. D., Archibald, A. L., Paldi, A., Sinclair, K. D., Wattis, J., & Rauch, C. (2024). Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping. Physiological Genomics, 56(11), 791-806. https://doi.org/10.1152/physiolgenomics.00049.2024

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R.A. Fisher, genome-wide association studies (GWAS) extract information using averages and varia... Read More about Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping.

Topo-Geometric Analysis of Variability in Point Clouds using Persistence Landscapes (2024)
Journal Article
Matuk, J., Kurtek, S., & Bharath, K. (2024). Topo-Geometric Analysis of Variability in Point Clouds using Persistence Landscapes. IEEE Transactions on Pattern Analysis and Machine Intelligence, 46(12), 11035-11046. https://doi.org/10.1109/TPAMI.2024.3451328

Topological data analysis provides a set of tools to uncover low-dimensional structure in noisy point clouds. Prominent amongst the tools is persistence homology, which summarizes birth-death times of homological features using data objects known as... Read More about Topo-Geometric Analysis of Variability in Point Clouds using Persistence Landscapes.

Complex-plane singularity dynamics for blow up in a nonlinear heat equation: analysis and computation (2024)
Journal Article
Fasondini, M., King, J. R., & Weideman, J. A. (2024). Complex-plane singularity dynamics for blow up in a nonlinear heat equation: analysis and computation. Nonlinearity, 37(10), Article 105005. https://doi.org/10.1088/1361-6544/ad700b

Blow-up solutions to a heat equation with spatial periodicity and a quadratic nonlinearity are studied through asymptotic analyses and a variety of numerical methods. The focus is on tracking the dynamics of the singularities in the complexified spac... Read More about Complex-plane singularity dynamics for blow up in a nonlinear heat equation: analysis and computation.

Optimising experimental designs for model selection of ion channel drug binding mechanisms (2024)
Preprint / Working Paper
Patten-Elliott, F., Lei, C. L., Preston, S. P., Wilkinson, R. D., & Mirams, G. R. Optimising experimental designs for model selection of ion channel drug binding mechanisms

The rapid delayed rectifier current carried by the human Ether-à-go-go-Related Gene (hERG) channel is susceptible to drug-induced reduction which can lead to an increased risk of cardiac arrhythmia. Establishing the mechanism by which a specific drug... Read More about Optimising experimental designs for model selection of ion channel drug binding mechanisms.

MPeat2D - a fully coupled mechanical-ecohydrological model of peatland development in two dimensions (2024)
Journal Article
Mahdiyasa, A. W., Large, D. J., Icardi, M., & Muljadi, B. P. (2024). MPeat2D - a fully coupled mechanical-ecohydrological model of peatland development in two dimensions. Earth Surface Dynamics, 12(4), 929-952. https://doi.org/10.5194/esurf-12-929-2024

Higher-dimensional models of peatland development are required to analyse the influence of spatial heterogeneity and complex feedback mechanisms on peatland behaviour. However, the current models exclude the mechanical process that leads to uncertain... Read More about MPeat2D - a fully coupled mechanical-ecohydrological model of peatland development in two dimensions.

Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs (2024)
Preprint / Working Paper
Shuttleworth, J. G., Lei, C. L., Windley, M. J., Hill, A. P., Preston, S. P., & Mirams, G. R. Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs

Mathematical models are increasingly being relied upon to provide quantitatively accurate predictions of cardiac electrophysiology. Many such models concern the behaviour of particular subcellular components (namely, ion channels) which, together, al... Read More about Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs.

A range of voltage-clamp protocol designs for rapid capture of hERG kinetics (2024)
Preprint / Working Paper
Lei, C. L., Whittaker, D. G., Windley, M. J., Perry, M. D., Hill, A. P., & Mirams, G. R. A range of voltage-clamp protocol designs for rapid capture of hERG kinetics

We provide details of a series of short voltage-clamp protocols designed for gathering a large amount of information on hERG (Kv11.1) ion channel gating. The protocols have a limited number of steps and consist only of steps and ramps, making them ea... Read More about A range of voltage-clamp protocol designs for rapid capture of hERG kinetics.

Geometry of Spin(10) symmetry breaking (2024)
Journal Article
Krasnov, K. (2024). Geometry of Spin(10) symmetry breaking. Journal of Mathematical Physics, 65(8), Article 082302. https://doi.org/10.1063/5.0210073

We provide a new characterisation of the Standard Model gauge group GSM as a subgroup of Spin(10). The new description of GSM relies on the geometry of pure spinors. We show that GSM ⊂ Spin(10) is the group that stabilises a pure spinor Ψ1 and projec... Read More about Geometry of Spin(10) symmetry breaking.

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping (2024)
Preprint / Working Paper
Kyratzi, P., Matika, O., Brassington, A. H., Connie, C. E., Xu, J., Barrett, D. A., Emes, R. D., Archibald, A. L., Paldi, A., Sinclair, K. D., Wattis, J., & Rauch, C. Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R.A. Fisher, genome-wide association studies (GWAS) extract information using averages and varia... Read More about Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping.