Outputs (3)

Exploiting the Plasticity of Primary and Secondary Response Mechanisms in Artificial Immune Systems (2016)
Presentation / Conference Contribution
Greensmith, J., Jackson, A. M., & Spendlove, I. (2016). Exploiting the Plasticity of Primary and Secondary Response Mechanisms in Artificial Immune Systems. In Proceedings of the 2016 on Genetic and Evolutionary Computation Conference Companion - GECCO '16 Companion (7-8). https://doi.org/10.1145/2908961.2908962

One of the key properties of the human immune system is to detect the presence of pathogens, and as such there are numberous immune algorithm which perform anomaly detection and pattern recognition. An additional facet of the human immune system is t... Read More about Exploiting the Plasticity of Primary and Secondary Response Mechanisms in Artificial Immune Systems.

Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation (2016)
Journal Article
Malecka, A., Wang, O., Shah, S., Sutavani, R. V., Spendlove, I., Ramage, J. M., …Jackson, A. M. (2016). Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation. Journal of Leukocyte Biology, 100(2), 381-389. https://doi.org/10.1189/jlb.3A1015-474R

Dendritic cell function is modulated by stromal cells, including fibroblasts. Although poorly understood, the signals delivered through this crosstalk substantially alter dendritic cell biology. This is well illustrated with release of TNF-0/IL-113 f... Read More about Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation.

Simulating the dynamics of T cell subsets throughout the lifetime (2011)
Book Chapter
Foan, S., Jackson, A. M., Spendlove, I., & Aickelin, U. (2011). Simulating the dynamics of T cell subsets throughout the lifetime. In P. Liò, G. Nicosia, & T. Stibor (Eds.), Artificial immune systems: 10th international conference, ICARIS 2011, Cambridge, UK, July 18-21, 2011: proceedings. Springer

It is widely accepted that the immune system undergoes age-related changes correlating with increased disease in the elderly. T cell subsets have been implicated. The aim of this work is firstly to implement and validate a simulation
of T regulatory... Read More about Simulating the dynamics of T cell subsets throughout the lifetime.