Outputs (118)

A Redox-Relay Heck Approach to Substituted Tetrahydrofurans (2023)
Journal Article
Byrne, T. J. M., Mylrea, M. E., & Cuthbertson, J. D. (2023). A Redox-Relay Heck Approach to Substituted Tetrahydrofurans. Organic Letters, 25(13), 2361-2365. https://doi.org/10.1021/acs.orglett.3c00769

An operationally simple and efficient strategy for the synthesis of substituted tetrahydrofurans from readily available cis-butene-1,4-diol is described. A redox-relay Heck reaction is used to rapidly access cyclic hemiacetals that can be directly re... Read More about A Redox-Relay Heck Approach to Substituted Tetrahydrofurans.

Diphosphoryl‐functionalized Polyoxometalates: Structurally and Electronically Tunable Hybrid Molecular Materials (2023)
Journal Article
Amin, S. S., Jones, K. D., Kibler, A. J., Damian, H. A., Cameron, J. M., Butler, K. S., Argent, S. P., Winslow, M., Robinson, D., Mitchell, N. J., Lam, H. W., & Newton, G. N. (2023). Diphosphoryl‐functionalized Polyoxometalates: Structurally and Electronically Tunable Hybrid Molecular Materials. Angewandte Chemie International Edition, 62(23), Article e202302446. https://doi.org/10.1002/anie.202302446

Herein, we report the synthesis and characterization of a new class of hybrid Wells–Dawson polyoxometalate (POM) containing a diphosphoryl group (P2O6X) of the general formula [P2W17O57(P2O6X)]6− (X=O, NH, or CR1R2). Modifying the bridging unit X was... Read More about Diphosphoryl‐functionalized Polyoxometalates: Structurally and Electronically Tunable Hybrid Molecular Materials.

Voltammetric Evidence of Proton Transport through the Sidewalls of Single-Walled Carbon Nanotubes (2023)
Journal Article
Jordan, J. W., Mortiboy, B., Khlobystov, A. N., Johnson, L. R., Newton, G. N., & Walsh, D. A. (2023). Voltammetric Evidence of Proton Transport through the Sidewalls of Single-Walled Carbon Nanotubes. Journal of the American Chemical Society, 145(16), 9052–9058. https://doi.org/10.1021/jacs.3c00554

Understanding ion transport in solid materials is crucial in the design of electrochemical devices. Of particular interest in recent years is the study of ion transport across 2-dimensional, atomically thin crystals. In this contribution, we describe... Read More about Voltammetric Evidence of Proton Transport through the Sidewalls of Single-Walled Carbon Nanotubes.

Poly (diglycerol adipate) variants as enhanced nanocarrier replacements in drug delivery applications (2023)
Journal Article
Jacob, P. L., Brugnoli, B., Del Giudice, A., Phan, H., Chauhan, V. M., Beckett, L., Gillis, R. B., Moloney, C., Cavanagh, R. J., Krumins, E., Reynolds-Green, M., Lentz, J. C., Conte, C., Cuzzucoli Crucitti, V., Couturaud, B., Galantini, L., Francolini, I., Howdle, S. M., & Taresco, V. (2023). Poly (diglycerol adipate) variants as enhanced nanocarrier replacements in drug delivery applications. Journal of Colloid and Interface Science, 641, 1043-1057. https://doi.org/10.1016/j.jcis.2023.03.124

Sustainably derived poly(glycerol adipate) (PGA) has been deemed to deliver all the desirable features expected in a polymeric scaffold for drug-delivery, including biodegradability, biocompatibility, self-assembly into nanoparticles (NPs) and a func... Read More about Poly (diglycerol adipate) variants as enhanced nanocarrier replacements in drug delivery applications.

Modification of Linear Polyethylenimine with Supercritical CO2: From Fluorescent Materials to Covalent Cross-Links (2023)
Journal Article
Mees, M. A., McAllister, T. D., Curia, S., Howdle, S. M., & Hoogenboom, R. (2023). Modification of Linear Polyethylenimine with Supercritical CO2: From Fluorescent Materials to Covalent Cross-Links. Macromolecules, 56(7), 2841-2851. https://doi.org/10.1021/acs.macromol.2c02443

Along with their DNA binding ability, the secondary amines in linear polyethylenimine (L-PEI) units can also act as a reaction platform to introduce new functionalities. This renders the possibility to make a plethora of copolymers without the burden... Read More about Modification of Linear Polyethylenimine with Supercritical CO2: From Fluorescent Materials to Covalent Cross-Links.

Synthesis of Fluorinated Hydrazinylthiazole Derivatives: A Virtual and Experimental Approach to Diabetes Management (2023)
Journal Article
Mehmood, H., Akhtar, T., Haroon, M., Khalid, M., Woodward, S., Asghar, M. A., Baby, R., Orfali, R., & Perveen, S. (2023). Synthesis of Fluorinated Hydrazinylthiazole Derivatives: A Virtual and Experimental Approach to Diabetes Management. ACS Omega, 8(12), 11433-11446. https://doi.org/10.1021/acsomega.3c00265

A novel series of fluorophenyl-based thiazoles was synthesized following the Hanztsch method. All of the compounds were initially verified with physical parameters (color, melting point, retardation factor (Rf)), which were further confirmed by sever... Read More about Synthesis of Fluorinated Hydrazinylthiazole Derivatives: A Virtual and Experimental Approach to Diabetes Management.

The Small Molecule Antagonist KCI807 Disrupts Association of the Amino-Terminal Domain of the Androgen Receptor with ELK1 by Modulating the Adjacent DNA Binding Domain (2023)
Journal Article
Soave, C., Ducker, C., Islam, N., Kim, S., Yurgelevic, S., Nicely, N. I., Pardy, L., Huang, Y., Shaw, P. E., Auner, G., Dickson, A., & Ratnam, M. (2023). The Small Molecule Antagonist KCI807 Disrupts Association of the Amino-Terminal Domain of the Androgen Receptor with ELK1 by Modulating the Adjacent DNA Binding Domain. Molecular Pharmacology, 103(4), 211-220. https://doi.org/10.1124/molpharm.122.000589

The androgen receptor (AR) is a crucial coactivator of ELK1 for prostate cancer (PCa) growth, associating with ELK1 through two peptide segments (358-457 and 514-557) within the amino-terminal domain (NTD) of AR. The small-molecule antagonist 5-hydro... Read More about The Small Molecule Antagonist KCI807 Disrupts Association of the Amino-Terminal Domain of the Androgen Receptor with ELK1 by Modulating the Adjacent DNA Binding Domain.

Subnanometer-Wide Indium Selenide Nanoribbons (2023)
Journal Article
Cull, W. J., Skowron, S. T., Hayter, R., Stoppiello, C. T., Rance, G. A., Biskupek, J., Kudrynskyi, Z. R., Kovalyuk, Z. D., Allen, C. S., Slater, T. J. A., Kaiser, U., Patanè, A., & Khlobystov, A. N. (2023). Subnanometer-Wide Indium Selenide Nanoribbons. ACS Nano, 17(6), 6062-6072. https://doi.org/10.1021/acsnano.3c00670

Indium selenides (InxSey) have been shown to retain several desirable properties, such as ferroelectricity, tunable photoluminescence through temperature-controlled phase changes, and high electron mobility when confined to two dimensions (2D). In th... Read More about Subnanometer-Wide Indium Selenide Nanoribbons.

Dynamic Disorder Drives Exciton Dynamics in Diketopyrrolopyrrole-Thiophene-Containing Molecular Crystals (2023)
Journal Article
Jiang, L., Hirst, J. D., & Do, H. (2023). Dynamic Disorder Drives Exciton Dynamics in Diketopyrrolopyrrole-Thiophene-Containing Molecular Crystals. Journal of Physical Chemistry C, 127(11), 5519-5532. https://doi.org/10.1021/acs.jpcc.2c07984

There is a growing interest in controllable molecular materials for potential nanophotonic and quantum information applications where excitons move beyond the incoherent transport regime. Thus, the ability to identify the key parameters that correlat... Read More about Dynamic Disorder Drives Exciton Dynamics in Diketopyrrolopyrrole-Thiophene-Containing Molecular Crystals.

Ferric Quinate (QPLEX) inhibits the interaction of Major Outer Membrane Protein (MOMP) with the Lewis b (Leb) antigen and Limits Campylobacter colonisation in broilers (2023)
Journal Article
Okoye, J. C., Holland, A., Pitoulias, M., Paschalis, V., Piddubnyi, A., Dufailu, O. A., Boren, T., Oldfield, N. J., Mahdari, J., & Soultanos, P. (2023). Ferric Quinate (QPLEX) inhibits the interaction of Major Outer Membrane Protein (MOMP) with the Lewis b (Leb) antigen and Limits Campylobacter colonisation in broilers. Frontiers in Microbiology, 14, Article 1146418. https://doi.org/10.3389/fmicb.2023.1146418

Campylobacter jejuni colonizes hosts by interacting with Blood Group Antigens (BgAgs) on the surface of gastrointestinal epithelia. Genetic variations in BgAg expression affects host susceptibility to C. jejuni. Here, we show that the essential major... Read More about Ferric Quinate (QPLEX) inhibits the interaction of Major Outer Membrane Protein (MOMP) with the Lewis b (Leb) antigen and Limits Campylobacter colonisation in broilers.