Outputs (69)

2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations (2020)
Journal Article
Englezou, G., Kortsen, K., Pacheco, A. A. C., Cavanagh, R., Lentz, J. C., Krumins, E., Sanders‐Velez, C., Howdle, S. M., Nedoma, A. J., & Taresco, V. (2020). 2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations. Journal of Polymer Science, 58(11), 1571-1581. https://doi.org/10.1002/pol.20200183

2‐methyltetrahydrofuran (2‐MeTHF) is a readily available, inexpensive, neoteric, bio‐based solvent. It has been adopted across a wide range of chemical processes including the batch manufacture of fine chemicals, enzymatic polycondensations and ring... Read More about 2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations.

Low-temperature and purification-free stereocontrolled ring-opening polymerisation of lactide in supercritical carbon dioxide (2020)
Journal Article
Bassett, S. P., Russell, A. D., McKeown, P., Robinson, I., Forder, T. R., Taresco, V., Davidson, M. G., & Howdle, S. M. (2020). Low-temperature and purification-free stereocontrolled ring-opening polymerisation of lactide in supercritical carbon dioxide. Green Chemistry, 22(7), 2197-2202. https://doi.org/10.1039/d0gc00352b

A stereoselective, solvent-free ring-opening polymerisation (ROP) of lactide (LA) in supercritical carbon dioxide (scCO2) is reported for the first time. The key aim is to exploit scCO2 to lower the temperature of traditional melt polymerisations, lo... Read More about Low-temperature and purification-free stereocontrolled ring-opening polymerisation of lactide in supercritical carbon dioxide.

Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery (2020)
Journal Article
Al-Natour, M. A., Yousif, M. D., Cavanagh, R., Abouselo, A., Apebende, E. A., Ghaemmaghami, A., Kim, D.-H., Aylott, J. W., Taresco, V., Chauhan, V. M., & Alexander, C. (2020). Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery. ACS Macro Letters, 9(3), 431-437. https://doi.org/10.1021/acsmacrolett.9b01014

Copyright © 2020 American Chemical Society. Poly(lactic-co-glycolic acid) (PLGA) is a versatile synthetic copolymer that is widely used in pharmaceutical applications. This is because it is well-tolerated in the body, and copolymers of varying physic... Read More about Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery.

Development of Pyrazolo[3,4- d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme (2020)
Journal Article
Greco, C., Taresco, V., Pearce, A. K., Vasey, C. E., Smith, S., Rahman, R., Alexander, C., Cavanagh, R. J., Musumeci, F., & Schenone, S. (2020). Development of Pyrazolo[3,4- d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme. ACS Medicinal Chemistry Letters, 11(5), 657-663. https://doi.org/10.1021/acsmedchemlett.9b00530

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor. Residual cells at the tumor margin are responsible for up to 85% of GBM recurrences after standard treatment. Despite this evidence, the identification of compounds active on t... Read More about Development of Pyrazolo[3,4- d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme.

Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device (2020)
Journal Article
Vestri, A., Pearce, A. K., Cavanagh, R., Styliari, I. D., Sanders, C., Couturaud, B., Schenone, S., Taresco, V., Jakobsen, R. R., Howdle, S. M., Musumeci, F., & Sagnelli, D. (2020). Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device. Coatings, 10(2), Article 125. https://doi.org/10.3390/coatings10020125

Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsul... Read More about Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device.

Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2) (2020)
Journal Article
d’Almeida Gamiero, M., Goddard, A. . R., Taresco, V., & Howdle, S. M. (2020). Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2). Green Chemistry, 22(4), 1308-1318. https://doi.org/10.1039/c9gc04011k

We seek to expand the opportunities to exploit glycerol, a largely untapped renewable feedstock, by exploiting enzymatic catalysis in supercritical carbon dioxide (scCO2). This work highlights a promising and clean approach to bio-renewable amphiphil... Read More about Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2).

A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers (2020)
Journal Article
O'Brien, D. M., Atkinson, R. L., Cavanagh, R., Pacheco, A. A., Larder, R., Kortsen, K., Krumins, E., Haddleton, A. J., Alexander, C., Stockman, R. A., Howdle, S. M., & Taresco, V. (2020). A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers. European Polymer Journal, 125, 109516. https://doi.org/10.1016/j.eurpolymj.2020.109516

© 2020 Elsevier Ltd In this work we aimed to achieve a totally sustainable Ring Opening Polymerisation (ROP) process, by harmonising the use of naturally occurring or derivable initiators and the green solvent 2-Methyltetrahydrofuran (2-MeTHF). First... Read More about A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers.

Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide (2019)
Journal Article
Sodano, F., Cavanagh, R., Pearce, A. K., Lazzarato, L., Rolando, B., Fraix, A., Fedatto Abelha, T., Vasey, C., Alexander, C., Taresco, V., & Sortino, S. (2020). Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide. Biomaterials Science, 8(5), 1329-1344. https://doi.org/10.1039/c9bm01644a

© 2020 The Royal Society of Chemistry. Combinations of conventional chemotherapeutics with unconventional anticancer agents such as reactive oxygen and nitrogen species may offer treatment benefits for cancer therapies. Here we report a novel polymer... Read More about Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide.

A simple and efficient method for polymer coating of iron oxide nanoparticles (2019)
Journal Article
Abushrida, A., Elhuni, I., Taresco, V., Marciani, L., Stolnik, S., & Garnett, M. C. (2020). A simple and efficient method for polymer coating of iron oxide nanoparticles. Journal of Drug Delivery Science and Technology, 55, Article 101460. https://doi.org/10.1016/j.jddst.2019.101460

Iron oxide nanoparticles (IONP) have many possible uses including as MRI contrast agents, for drug delivery and cell labelling, but need to be stabilised and to be rendered biocompatible through appropriate coatings. Many current coatings are subopti... Read More about A simple and efficient method for polymer coating of iron oxide nanoparticles.

Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocomposites (2019)
Journal Article
Francolini, I., Taresco, V., Martinelli, A., & Piozzi, A. (2020). Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocomposites. Enzyme and Microbial Technology, 132, Article 109439. https://doi.org/10.1016/j.enzmictec.2019.109439

Lipase-immobilized nanomaterials with high activity and stable reusability would have a great impact in different fields. However, developing such materials has proven to be challenging. Herein, polymer (pAcDED)-coated magnetic nanoparticles (MNPs) d... Read More about Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocomposites.