Outputs (11)

Structural Transformations of Metal-Organic Cages through Tetrazine-Alkene Reactivity (2024)
Journal Article
Black, M. R., Bhattacharyya, S., Argent, S. P., & Pilgrim, B. S. (2024). Structural Transformations of Metal-Organic Cages through Tetrazine-Alkene Reactivity. Journal of the American Chemical Society, 146(41), 28233-28241. https://doi.org/10.1021/jacs.4c08591

The assembly of metal-organic cages is governed by metal ion coordination preferences and the geometries of the typically rigid and planar precursor ligands. PdnL2n cages are among the most structurally diverse, with subtle differences in the metal-l... Read More about Structural Transformations of Metal-Organic Cages through Tetrazine-Alkene Reactivity.

Mechanically interlocked molecular handcuffs (2022)
Journal Article
Pearce, N., Tarnowska, M., Andersen, N. J., Wahrhaftig-Lewis, A., Pilgrim, B. S., & Champness, N. R. (2022). Mechanically interlocked molecular handcuffs. Chemical Science, 13(14), 3915-3941. https://doi.org/10.1039/d2sc00568a

The field of mechanically interlocked molecules that employ a handcuff component are reviewed. The variety of rotaxane and catenane structures that use the handcuff motif to interlock different components are discussed and a new nomenclature, distill... Read More about Mechanically interlocked molecular handcuffs.

The chemistry of phosphines in constrained, well-defined microenvironments (2021)
Journal Article
Orton, G. R. F., Pilgrim, B. S., & Champness, N. R. (2021). The chemistry of phosphines in constrained, well-defined microenvironments. Chemical Society Reviews, 50(7), 4411-4431. https://doi.org/10.1039/d0cs01556c

Developments in the confinement of phosphines within micro- or nano-environments are explored. Phosphines are ubiquitous across metal coordination chemistry and underpin some of the most famous homogeneous transition metal catalysts. Constraining pho... Read More about The chemistry of phosphines in constrained, well-defined microenvironments.

Metal-Organic Frameworks and Metal-Organic Cages – A Perspective (2020)
Journal Article
Pilgrim, B., & Champness, N. R. (2020). Metal-Organic Frameworks and Metal-Organic Cages – A Perspective. ChemPlusChem, 85(8), 1842-1856. https://doi.org/10.1002/cplu.202000408

© 2020 Wiley-VCH GmbH The fields of metal-organic cages (MOCs) and metal-organic frameworks (MOFs) are both highly topical and continue to develop at a rapid pace. Despite clear synergies between the two fields, overlap is rarely observed. This artic... Read More about Metal-Organic Frameworks and Metal-Organic Cages – A Perspective.

Dynamic pH responsivity of triazole-based self-immolative linkers (2020)
Journal Article
Stevens, M. M., Roberts, D. A., Pilgrim, B. S., & Dell, T. N. (2020). Dynamic pH responsivity of triazole-based self-immolative linkers. Chemical Science, 11(14), 3713-3718. https://doi.org/10.1039/d0sc00532k

Gating the release of chemical payloads in response to transient signals is an important feature of ‘smart’ delivery systems. Herein, we report a triazole-based self-immolative linker that can be reversibly paused or slowed and restarted throughout i... Read More about Dynamic pH responsivity of triazole-based self-immolative linkers.

Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4L6 Tetrahedron (2018)
Journal Article
von Krbek, L. K. S., Roberts, D. A., Pilgrim, B. S., Schalley, C. A., & Nitschke, J. R. (2018). Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4L6 Tetrahedron. Angewandte Chemie International Edition, 57(43), 14121-14124. https://doi.org/10.1002/anie.201808534

We report a strategy for regulating the rate of internally bound anion exchange within an Fe4L6 metal–organic tetrahedron through external coordination of tripodal tris(alkylammonium) cations. The cage features three flexible 18‐crown‐6 receptors at... Read More about Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4L6 Tetrahedron.

Covalent Post-assembly Modification Triggers Multiple Structural Transformations of a Tetrazine-Edged Fe4L6 Tetrahedron (2018)
Journal Article
Roberts, D. A., Pilgrim, B. S., Sirvinskaite, G., Ronson, T. K., & Nitschke, J. R. (2018). Covalent Post-assembly Modification Triggers Multiple Structural Transformations of a Tetrazine-Edged Fe4L6 Tetrahedron. Journal of the American Chemical Society, 140(30), 9616-9623. https://doi.org/10.1021/jacs.8b05082

Covalent post-assembly modification (PAM) reactions are useful synthetic tools for functionalizing and stabilizing self-assembled metal–organic complexes. Recently, PAM reactions have also been explored as stimuli for triggering supramolecular struct... Read More about Covalent Post-assembly Modification Triggers Multiple Structural Transformations of a Tetrazine-Edged Fe4L6 Tetrahedron.

Signal transduction in a covalent post-assembly modification cascade (2017)
Journal Article
Pilgrim, B. S., Roberts, D. A., Lohr, T. G., Ronson, T. K., & Nitschke, J. R. (2017). Signal transduction in a covalent post-assembly modification cascade. Nature Chemistry, 9(12), 1276-1281. https://doi.org/10.1038/nchem.2839

Natural reaction cascades control the movement of biomolecules between cellular compartments. Inspired by these systems, we report a synthetic reaction cascade employing post-assembly modification reactions to direct the partitioning of supramolecula... Read More about Signal transduction in a covalent post-assembly modification cascade.

Perfluorinated Ligands Induce Meridional Metal Stereochemistry to Generate M8L12, M10L15, and M12L18 Prisms (2016)
Journal Article
Kieffer, M., Pilgrim, B. S., Ronson, T. K., Roberts, D. A., Aleksanyan, M., & Nitschke, J. R. (2016). Perfluorinated Ligands Induce Meridional Metal Stereochemistry to Generate M8L12, M10L15, and M12L18 Prisms. Journal of the American Chemical Society, 138(21), 6813-6821. https://doi.org/10.1021/jacs.6b02445

FeII4L6 tetrahedral cage 1 undergoes post-assembly modification (PAM) via a Diels–Alder cycloaddition of the anthracene panels of the cage with tetracyanoethylene (TCNE). The modified cage 2 possesses an enclosed cavity suitable for encapsulation of... Read More about Perfluorinated Ligands Induce Meridional Metal Stereochemistry to Generate M8L12, M10L15, and M12L18 Prisms.

Post-assembly Modification of Tetrazine-Edged FeII4L6 Tetrahedra (2015)
Journal Article
Roberts, D. A., Pilgrim, B. S., Cooper, J. D., Ronson, T. K., Zarra, S., & Nitschke, J. R. (2015). Post-assembly Modification of Tetrazine-Edged FeII4L6 Tetrahedra. Journal of the American Chemical Society, 137(32), 10068-10071. https://doi.org/10.1021/jacs.5b05080

Post-assembly modification (PAM) is a powerful tool for the modular functionalization of self-assembled structures. We report a new family of tetrazine-edged FeII4L6 tetrahedral cages, prepared using different aniline subcomponents, which undergo rap... Read More about Post-assembly Modification of Tetrazine-Edged FeII4L6 Tetrahedra.