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Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4L6 Tetrahedron

von?Krbek, Larissa K. S.; Roberts, Derrick A.; Pilgrim, Ben S.; Schalley, Christoph A.; Nitschke, Jonathan R.

Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4L6 Tetrahedron Thumbnail


Authors

Larissa K. S. von?Krbek

Derrick A. Roberts

Christoph A. Schalley

Jonathan R. Nitschke



Abstract

We report a strategy for regulating the rate of internally bound anion exchange within an Fe4L6 metal–organic tetrahedron through external coordination of tripodal tris(alkylammonium) cations. The cage features three flexible 18‐crown‐6 receptors at each of its FeII vertices, facilitating strong tritopic interactions with tris(ammonium) cations to “cap” the vertices of the tetrahedron. This capping mechanism restricts the flexibility of the cage framework, thereby reducing the rate of anion exchange within its central cavity by 20‐fold. Thus, we demonstrate the first use of an externally bound multivalent effector to allosterically control internal guest binding in a molecular cage.

Citation

von Krbek, L. K. S., Roberts, D. A., Pilgrim, B. S., Schalley, C. A., & Nitschke, J. R. (2018). Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4L6 Tetrahedron. Angewandte Chemie International Edition, 57(43), 14121-14124. https://doi.org/10.1002/anie.201808534

Journal Article Type Article
Acceptance Date Oct 16, 2018
Online Publication Date Sep 27, 2018
Publication Date Oct 22, 2018
Deposit Date Feb 24, 2020
Publicly Available Date Mar 28, 2024
Journal Angewandte Chemie International Edition
Print ISSN 1433-7851
Electronic ISSN 1521-3773
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 57
Issue 43
Pages 14121-14124
DOI https://doi.org/10.1002/anie.201808534
Public URL https://nottingham-repository.worktribe.com/output/4026670
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201808534
Additional Information This is the peer reviewed version of the following article: L. K. S. von Krbek, D. A. Roberts, B. S. Pilgrim, C. A. Schalley, J. R. Nitschke, Angew. Chem. Int. Ed. 2018, 57, 14121, which has been published in final form at https://doi.org/10.1002/anie.201808534. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

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