Outputs (3)

Pathology in practice: hereditary nephropathy in an English Cocker Spaniel (2017)
Journal Article
de Brot, S., Adamany, J., Baiker, K., Allegrucci, C., Polledo, L., & Grau-Roma, L. (2017). Pathology in practice: hereditary nephropathy in an English Cocker Spaniel. Journal of the American Veterinary Medical Association, 251(6), 661-664. https://doi.org/10.2460/javma.251.6.661

A thirteen-month-old male neutered orange roan English Cocker Spaniel dog was euthanized due to a prolonged history of lethargy, weight loss, severe azotemia and marked proteinuria, which was suggestive of chronic renal failure. At necropsy, both kid... Read More about Pathology in practice: hereditary nephropathy in an English Cocker Spaniel.

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., Sybirna, A., Contreras, D., Webb, R., Allegrucci, C., Alberio, R., & Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, https://doi.org/10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More about Principles of early human development and germ cell program from conserved model systems.

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development (2017)
Journal Article
Metzler, V. M., de Brot, S., Robinson, R. S., Jeyapalan, J. N., Rakha, E., Walton, T., Gardner, D. S., Lund, E. F., Whitchurch, J., Haigh, D., Lochray, J. M., Robinson, B. D., Allegrucci, C., Fray, R. G., Persson, J. L., Ødum, N., Miftakhova, R. R., Rizvanov, A. A., Hughes, I. A., Tadokoro-Cuccaro, R., …Mongan, N. P. (2017). Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development. Placenta, 56, 79-85. https://doi.org/10.1016/j.placenta.2017.02.018

The placenta and tumors share important characteristics, including a requirement to establish effective angiogenesis. In the case of the placenta, optimal angiogenesis is required to sustain the blood flow required to maintain a successful pregnancy,... Read More about Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development.