Outputs (139)

Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus (2016)
Journal Article
Richard, Y., Maan, S., Maan, N. S., Belaganahalli, M. N., Potgieter, A. C., Kumar, V., …Mertens, P. P. (2016). Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus. PLoS ONE, 11(9), Article e0163014. https://doi.org/10.1371/journal.pone.0163014

Bluetongue virus is the type species of the genus Orbivirus, family Reoviridae. Bluetongue viruses (BTV) are transmitted between their vertebrate hosts primarily by biting midges (Culicoides spp.) in which they also replicate. Consequently BTV distri... Read More about Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article
Sulak, M., Fong, L., Mika, K., Chigurupati, S., Yon, L., Mongan, N. P., …Lynch, V. J. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5(2016), Article e11994. https://doi.org/10.7554/eLife.11994.001

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article
Michael, S., Lindsey, F., Katelyn, M., Sravanthi, C., Lisa, Y., Nigel P, M., …Vincent J, L. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5, Article e11994. https://doi.org/10.7554/eLife.11994.001

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge (2016)
Journal Article
Lankester, F., Lugelo, A., Werling, D., Mnyambwa, N., Keyyu, J., Kazwala, R., …Haig, D. (2016). The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge. Veterinary Microbiology, 195, 144-153. https://doi.org/10.1016/j.vetmic.2016.09.019

Malignant catarrhal fever (MCF) is a fatal disease of cattle that, in East Africa, follows contact with wildebeest excreting alcelaphine herpesvirus 1 (AlHV-1). Recently an attenuated vaccine (atAlHV-1) was tested under experimental challenge on Frie... Read More about The efficacy of alcelaphine herpesvirus-1 (AlHV-1) immunization with the adjuvants Emulsigen® and the monomeric TLR5 ligand FliC in zebu cattle against AlHV-1 malignant catarrhal fever induced by experimental virus challenge.

A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds (2016)
Journal Article
Down, P., Bradley, A., Breen, J., Browne, W., Kypraios, T., & Green, M. (2016). A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds. Preventive Veterinary Medicine, 133, 64-72. https://doi.org/10.1016/j.prevetmed.2016.09.012

Importance of the dry period with respect to mastitis control is now well established although the precise interventions that reduce the risk of acquiring intramammary infections during this time are not clearly understood. There are very few interve... Read More about A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds.

Factors influencing veterinary surgeons’ decision-making about dairy cattle vaccination (2016)
Journal Article
Richens, I., Hobson-West, P., Brennan, M. L., Hood, Z., Kaler, J., Green, M., …Wapenaar, W. (in press). Factors influencing veterinary surgeons’ decision-making about dairy cattle vaccination. Veterinary Record, 179(16), https://doi.org/10.1136/vr.103822

The use of vaccines in the cattle industry is widespread; however, there is limited published guidance for use by decision-makers such as farmers and vets. To best support vets in advising dairy farmers on the optimisation of vaccination strategies,... Read More about Factors influencing veterinary surgeons’ decision-making about dairy cattle vaccination.

Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors (2016)
Journal Article
Muthukaruppan, A., Lasham, A., Woad, K. J., Black, M. A., Blenkiron, C., Miller, L. D., …Print, C. G. (2017). Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors. Clinical Breast Cancer, 17(2), https://doi.org/10.1016/j.clbc.2016.09.001

Background

Molecular markers have transformed our understanding of the heterogeneity of breast cancer and have allowed the identification of genomic profiles of estrogen receptor (ER)-α signaling. However, our understanding of the transcriptional... Read More about Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors.

Lameness in dairy heifers; impacts of hoof lesions present around first calving on future lameness, milk yield and culling risk (2016)
Journal Article
Randall, L., Green, M. J., Chagunda, M., Mason, C., Green, L., & Huxley, J. (in press). Lameness in dairy heifers; impacts of hoof lesions present around first calving on future lameness, milk yield and culling risk. Preventive Veterinary Medicine, 133, https://doi.org/10.1016/j.prevetmed.2016.09.006

The importance of lameness in primiparous dairy heifers is increasingly recognised. Although it is accepted that clinical lameness in any lactation increases the risk of future lameness, the impact of foot lesions during the first lactation on long-t... Read More about Lameness in dairy heifers; impacts of hoof lesions present around first calving on future lameness, milk yield and culling risk.

Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro (2016)
Journal Article
Ortega-Rivas, A., Padrón, J. M., Valladares, B., & Elsheikha, H. M. (2016). Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro. Acta Tropica, 164, 95-99. https://doi.org/10.1016/j.actatropica.2016.09.006

Despite significant public health impact, there is no specific antiprotozoal therapy for prevention and treatment of Acanthamoeba castellanii infection. There is a need for new and efficient anti-Acanthamoeba drugs that are less toxic and can reduce... Read More about Acanthamoeba castellanii : A new high-throughput method for drug screening in vitro.

Ovine footrot: new insights into bacterial colonisation (2016)
Journal Article
Maboni, G., Frosth, S., Aspán, A., & Tötemeyer, S. (2016). Ovine footrot: new insights into bacterial colonisation. Veterinary Record, 179(9), Article 228. https://doi.org/10.1136/vr.103610

Ovine footrot is characterised by interdigital dermatitis (ID) and by the separation of the skin and hoof horn (under-running footrot). Dichelobacter nodosus is the essential pathogen causing footrot; the role of other microorganisms in this disease... Read More about Ovine footrot: new insights into bacterial colonisation.