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The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits (2014)
Journal Article

Alcelaphine herpesvirus-1 (AlHV-1) causes malignant catarrhal fever (MCF). The A2 gene of AlHV-1 is a member of the bZIP transcription factor family. We wished to determine whether A2 is a virulence gene or not and whether it is involved in pathogene... Read More about The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits.

Using simulation to interpret a discrete time survival model in a complex biological system: fertility and lameness in dairy cows (2014)
Journal Article
Hudson, C. D., Huxley, J. N., & Green, M. J. (2014). Using simulation to interpret a discrete time survival model in a complex biological system: fertility and lameness in dairy cows. PLoS ONE, 9(8), https://doi.org/10.1371/journal.pone.0103426

The ever-growing volume of data routinely collected and stored in everyday life presents researchers with a number of opportunities to gain insight and make predictions. This study aimed to demonstrate the usefulness in a specific clinical context of... Read More about Using simulation to interpret a discrete time survival model in a complex biological system: fertility and lameness in dairy cows.

Influenza A Virus Acquires Enhanced Pathogenicity and Transmissibility after Serial Passages in Swine (2014)
Journal Article
Wei, K., Sun, H., Sun, Z., Sun, Y., Kong, W., Pu, J., …Liu, J. (2014). Influenza A Virus Acquires Enhanced Pathogenicity and Transmissibility after Serial Passages in Swine. Journal of Virology, 88(20), 11981-11994. https://doi.org/10.1128/jvi.01679-14

Genetic and phylogenetic analyses suggest that the pandemic H1N1/2009 virus was derived from well-established swine influenza lineages; however, there is no convincing evidence that the pandemic virus was generated from a direct precursor in pigs. Fu... Read More about Influenza A Virus Acquires Enhanced Pathogenicity and Transmissibility after Serial Passages in Swine.

Immediate early protein of equid herpesvirus type 1 as a target for cytotoxic T-lymphocytes in the thoroughbred horse (2014)
Journal Article
Kydd, J. H., Case, R., Minke, J., Audonnet, J.-C., Wagner, B., & Antczak, D. F. (in press). Immediate early protein of equid herpesvirus type 1 as a target for cytotoxic T-lymphocytes in the thoroughbred horse. Journal of General Virology, 95, https://doi.org/10.1099/vir.0.065888-0

Cytotoxic T-lymphocytes (CTLs) are associated with protective immunity against disease caused by equid herpesvirus type 1 (EHV-1). However, the EHV-1 target proteins for CTLs are poorly defined. This limits the development of vaccine candidates desig... Read More about Immediate early protein of equid herpesvirus type 1 as a target for cytotoxic T-lymphocytes in the thoroughbred horse.

Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development (2014)
Journal Article
Dunford, L. J., Sinclair, K. D., Kwong, W. Y., Sturrock, C., Clifford, B. L., Giles, T. C., & Gardner, D. S. (2014). Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development. FASEB Journal, 28(11), 4880-4892. https://doi.org/10.1096/fj.14-255364

This paper identifies a common nutritional pathway relating maternal through to fetal protein-energy malnutrition (PEM) and compromised fetal kidney development. Thirty-one twin-bearing sheep were fed either a control (n=15) or low-protein diet (n=16... Read More about Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.

The detection of aquatic animal species using environmental DNA – a review of eDNA as a survey tool in ecology (2014)
Journal Article
Rees, H. C., Maddison, B. C., Middleditch, D. J., Patmore, J. R., & Gough, K. C. (2014). The detection of aquatic animal species using environmental DNA – a review of eDNA as a survey tool in ecology. Journal of Applied Ecology, 51, https://doi.org/10.1111/1365-2664.12306

1. Knowledge of species distribution is critical to ecological management and conservation biology. Effective management requires the detection of populations, which can sometimes be at low densities and is usually based on visual detection and count... Read More about The detection of aquatic animal species using environmental DNA – a review of eDNA as a survey tool in ecology.

A questionnaire-based survey on the uptake and use of cattle vaccines in the UK (2014)
Journal Article
Cresswell, E., Brennan, M. L., Barkema, H., & Wapenaar, W. (2014). A questionnaire-based survey on the uptake and use of cattle vaccines in the UK. Veterinary Record Open, 1(1), Article e000042. https://doi.org/10.1136/vropen-2014-000042

Background: Vaccination is a widely used strategy for disease control in cattle in the UK and abroad. However, there has been limited research describing the uptake and use of cattle vaccines on UK farms.
Aim: To describe the current uptake and usag... Read More about A questionnaire-based survey on the uptake and use of cattle vaccines in the UK.

Prospective survey of veterinary practitioners’ primary assessment of equine colic: clinical features, diagnoses, and treatment of 120 cases of large colon impaction (2014)
Journal Article
Jennings, K., Curtis, L., Burford, J., & Freeman, S. (2014). Prospective survey of veterinary practitioners’ primary assessment of equine colic: clinical features, diagnoses, and treatment of 120 cases of large colon impaction. BMC Veterinary Research, 10(Suppl), Article S2. https://doi.org/10.1186/1746-6148-10-S1-S2

Background

Large colon impactions are a common cause of colic in the horse. There are no scientific reports on the clinical presentation, diagnostic tests and treatments used in first opinion practice for large colon impaction cases. The aim of th... Read More about Prospective survey of veterinary practitioners’ primary assessment of equine colic: clinical features, diagnoses, and treatment of 120 cases of large colon impaction.

Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. (2014)
Journal Article

Changes to the DNA methylome have been described in patients with rheumatoid arthritis (RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte and B-lymphocyte populations from healthy individuals. Now, using HumanMeth... Read More about Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations..