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Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma gondii-Induced Transcriptional Landscapes (2019)
Journal Article
He, J., Ma, J., Wang, J., Zhang, F., Li, J., Zhai, B., …Zhu, X. (2019). Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma gondii-Induced Transcriptional Landscapes. Frontiers in Immunology, 10, Article 1531. https://doi.org/10.3389/fimmu.2019.01531

© 2019 He, Ma, Wang, Zhang, Li, Zhai, Wang, Elsheikha and Zhu. We characterized the porcine tissue transcriptional landscapes that follow Toxoplasma gondii infection. RNAs were isolated from liver, spleen, cerebral cortex, lung, and mesenteric lymph... Read More about Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma gondii-Induced Transcriptional Landscapes.

New insights into the mechanical properties of Acanthamoeba castellanii cysts as revealed by phonon microscopy (2019)
Journal Article
Pérez-Cota, F., Smith, R. J., Elsheikha, H. M., & Clark, M. (2019). New insights into the mechanical properties of Acanthamoeba castellanii cysts as revealed by phonon microscopy. Biomedical Optics Express, 10(5), 2399-2408. https://doi.org/10.1364/BOE.10.002399

The single cell eukaryotic protozoan Acanthamoeba castellanii exhibits a remarkable ability to switch from a vegetative trophozoite stage to a cystic form, in response to stressors. This phenotypic switch involves changes in gene expression and synth... Read More about New insights into the mechanical properties of Acanthamoeba castellanii cysts as revealed by phonon microscopy.

Label-free characterization of biochemical changes within human cells under parasite attack using synchrotron based micro-FTIR (2019)
Journal Article
Elsheikha, H. M., Elsaied, N. A., Chan, K. L. A., Brignell, C., Harun, M. S. R., Wehbe, K., & Cinquee, G. (2019). Label-free characterization of biochemical changes within human cells under parasite attack using synchrotron based micro-FTIR. Analytical Methods, 11(19), 2518-2530. https://doi.org/10.1039/c8ay02777c

© 2019 The Royal Society of Chemistry. The protozoan Toxoplasma gondii is responsible for severe, potentially life-threatening, infection in immunocompromised individuals and when acquired during pregnancy. In the meantime, there is no available vacc... Read More about Label-free characterization of biochemical changes within human cells under parasite attack using synchrotron based micro-FTIR.

Prevalence of feline lungworm Aelurostrongylus abstrusus in England (2019)
Journal Article
Elsheikha, H. M., Wright, I., Wang, B., & Schaper, R. (2019). Prevalence of feline lungworm Aelurostrongylus abstrusus in England. Veterinary parasitology (Amsterdam), 16, 100271. https://doi.org/10.1016/j.vprsr.2019.100271

Infection of cats with lungworm Aelurostrongylus abstrusus has recentlbeen documented in the UK. Here, we aimed to study the prevalence of A. abstrusus in fecal samples from cats across England. A total of 950 fecal samples were collected from cats t... Read More about Prevalence of feline lungworm Aelurostrongylus abstrusus in England.

Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities and Perspectives (2019)
Journal Article
Wang, J.-L., Zhang, N.-Z., Li, T.-T., He, J.-J., Elsheikha, H. M., & Zhu, X.-Q. (2019). Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities and Perspectives. Trends in Parasitology, 35(3), 239-253. https://doi.org/10.1016/j.pt.2019.01.005

Important progress has been made in understanding how immunity is elicited against Toxoplasma gondii - a complex pathogen with multiple mechanisms of immune evasion. Many vaccine candidates have been tested using various strategies in animal models.... Read More about Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities and Perspectives.

Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures (2018)
Journal Article
Cong, W., Dottorini, T., Khan, F., Emes, R. D., Zhang, F.-K., Zhou, C.-X., …Zhu, X.-Q. (2018). Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures. Frontiers in Immunology, 9, Article 2403. https://doi.org/10.3389/fimmu.2018.02403

RNA-sequencing was used to detect transcriptional changes in six tissues of cats, seven days after T. gondii infection. A total of 737 genes were differentially expressed (DEGs), of which 410 were up-regulated and 327 were down-regulated. The liver e... Read More about Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures.

Parasites and pets: a veterinary nursing guide (2018)
Book
Elsheikha, H., Wright, I. G., & McGarry, J. W. (2018). H. M. Elsheikha (Ed.). Parasites and pets: a veterinary nursing guide. CAB International. https://doi.org/10.1079/9781786394040.0000

This book, primarily focussing on parasitic diseases of cats and dogs, is designed specifically for veterinary nurses and students and adopts an enquiry based approach essential for consolidating knowledge and a deep practical understanding of this i... Read More about Parasites and pets: a veterinary nursing guide.

Immunization with a DNA vaccine cocktail encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 genes protects mice against chronic toxoplasmosis (2018)
Journal Article
Zhang, N.-Z., Gao, Q., Wang, M., Elsheikha, H. M., Wang, B., Wang, J.-L., Zhang, F.-K., Hu, L.-Y., & Zhu, X.-Q. (in press). Immunization with a DNA vaccine cocktail encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 genes protects mice against chronic toxoplasmosis. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.01505

Toxoplasmosis is a zoonotic disease caused by the intracellular protozoan Toxoplasma gondii; and a major source of infection in humans is via ingestion of T. gondii tissue cysts. Ultimately, the goal of anti-toxoplasmosis vaccines is to elicit a sust... Read More about Immunization with a DNA vaccine cocktail encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 genes protects mice against chronic toxoplasmosis.

Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15 (2018)
Journal Article
Liu, Q., Gao, W.-W., Elsheikha, H. M., He, J.-J., Li, F.-C., Yang, W.-B., & Zhu, X.-Q. (2018). Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15. Parasitology Research, 117(9), 2785–2793. https://doi.org/10.1007/s00436-018-5966-8

Growth and replication of the protozoan parasite Toxoplasma gondii within host cell entail the production of several effector proteins, which the parasite exploits for counteracting the host’s immune response. Despite considerable research to define... Read More about Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15.