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Outputs (118)

Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system (2018)
Journal Article
Li, F.-C., Liu, Q., Elsheikha, H. M., Yang, W.-B., Hou, J.-L., & Zhu, X.-Q. (in press). Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system. Parasitology Research, https://doi.org/10.1007/s00436-018-5812-z

Toxoplasma gondii deploys many effector proteins in order to hijack and manipulate host cell signaling pathways, allowing parasite colonization, subversion of immune responses, and disease progression. T. gondii effector protein 14-3-3 (Tg14-3-3) pro... Read More about Identification of two novel host proteins interacting with Toxoplasma gondii 14-3-3 protein by yeast two-hybrid system.

Novel Entamoeba findings in nonhuman primates (2018)
Journal Article
Elsheikha, H. M., Regan, C. S., & Clark, C. G. (2018). Novel Entamoeba findings in nonhuman primates. Trends in Parasitology, 34(4), https://doi.org/10.1016/j.pt.2017.12.008

In addition to well-known human-infecting species, Entamoeba species not found in humans have been identified recently in nonhuman primates (NHPs). Importantly, it has become clear that the organism identified as Entamoeba histolytica in NHPs is usua... Read More about Novel Entamoeba findings in nonhuman primates.

Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry (2018)
Journal Article
Zhou, C.-X., Cong, W., Chen, X.-Q., He, S.-Y., Elsheikha, H. M., & Zhu, X.-Q. (2018). Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02612

Toxoplasma gondii is an obligate intracellular parasite causing severe diseases in immunocompromised individuals and congenitally infected neonates, such as toxoplasmosis encephalitis and toxoplasmic chorioretinitis. This study aimed to determine whe... Read More about Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry.

Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica (2017)
Journal Article
Zhang, F.-K., Hou, J.-L., Guo, A.-J., Tian, A.-L., Shi, W., Sheng, Z.-A., …Zhu, X.-Q. (2018). Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica. Molecular Immunology, 94, https://doi.org/10.1016/j.molimm.2017.12.007

Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we invest... Read More about Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica.

Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes (2017)
Journal Article
Shi, W., Wei, Z.-Y., Elsheikha, H. M., Zhang, F.-K., Sheng, Z.-A., Lu, K.-J., …Zhu, X.-Q. (2017). Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes. Parasites and Vectors, 10(1), Article 602. https://doi.org/10.1186/s13071-017-2538-1

Background

Determining the mechanisms involved in the immune-pathogenesis of the tropical liver fluke, Fasciola gigantica, is crucial to the development of any effective therapeutic intervention. Here, we examined the differential gene expression... Read More about Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes.

Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China (2017)
Journal Article
Tian, A., Gu, Y.-L., Zhou, N., Cong, W., Liu, G.-X., Elsheikha, H. M., & Zhu, X.-Q. (in press). Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China. Infectious Diseases of Poverty, 6, Article 153. https://doi.org/10.1186/s40249-017-0367-2

Background: There is accumulating evidence for an increased susceptibility to infection in patients with arthritis. We sought to understand the epidemiology of Toxoplasma gondii infection in arthritis patients in eastern China, given the paucity of d... Read More about Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China.

Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica (2017)
Journal Article
Zhang, F.-K., Guo, A.-J., Hou, J.-L., Sun, M.-M., Sheng, Z.-A., Zhang, X.-X., …Zhu, X.-Q. (2017). Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica. Veterinary Parasitology, 244, 97-101. https://doi.org/10.1016/j.vetpar.2017.07.028

Fasciola gigantica infection in water buffaloes causes significant economic losses especially 27 in developing countries. Although modulation of the host immune response by cytokine 28 neutralization or vaccination is a promising approach to control... Read More about Serum levels of cytokines in water buffaloes experimentally infected with Fasciola gigantica.

Illustrated Dictionary of Parasitology in the Post-Genomic Era (2017)
Book
Elsheikha, H., & Jarroll, E. L. (2017). Illustrated Dictionary of Parasitology in the Post-Genomic Era. Caister Academic Press Limited. https://doi.org/10.21775/9781910190678

This illustrated dictionary provides concise definitions and explanations of parasitology terms and related molecular processes presented in an easy-to-use, A-Z order with particular emphasis on terms that are of relevance to parasite biotechnology a... Read More about Illustrated Dictionary of Parasitology in the Post-Genomic Era.

Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis (2017)
Journal Article
Chen, X.-Q., Zhou, C.-X., Elsheikha, H. M., He, S., Hu, G.-X., & Zhu, X.-Q. (2017). Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis. Parasites and Vectors, 10(1), Article 339. https://doi.org/10.1186/s13071-017-2282-6

Background

Toxoplasma gondii, a common opportunistic protozoan, is a leading cause of illness and mortality among immunosuppressed individuals and during congenital infections. Current therapeutic strategies for toxoplasmosis are not fully effecti... Read More about Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis.