Outputs (91)

Production and Application of Multicistronic Constructs for Various Human Disease Therapies (2019)
Journal Article
Shaimardanova, A. A., Kitaeva, K. V., Abdrakhmanova, I. I., Chernov, V. M., Rutland, C. S., Rizvanov, A. A., …Solovyeva, V. V. (2019). Production and Application of Multicistronic Constructs for Various Human Disease Therapies. Pharmaceutics, 11, 580. https://doi.org/10.3390/pharmaceutics11110580

The development of multicistronic vectors has opened up new opportunities to address the fundamental issues of molecular and cellular biology related to the need for the simultaneous delivery and joint expression of several genes. To date, the exampl... Read More about Production and Application of Multicistronic Constructs for Various Human Disease Therapies.

Potential therapeutic application of mesenchymal stem cells in ophthalmology (2019)
Journal Article
Zakirova, E. Y., Valeeva, A., Aimaletdinov, A., Nefedovskaya, L., Akhmetshin, R., Rutland, C., & Rizvanov, A. (2019). Potential therapeutic application of mesenchymal stem cells in ophthalmology. Experimental Eye Research, 189, Article 107863. https://doi.org/10.1016/j.exer.2019.107863

At present a wide variety of methods have been proposed to treat eye disorders, drug therapies are most commonly used. It should be noted that effective treatment modalities especially for degeneration of the retina and optic nerve are lacking. In th... Read More about Potential therapeutic application of mesenchymal stem cells in ophthalmology.

Reptilian skin and its special histological structures (2019)
Book Chapter
Rutland, C. S., Cigler, P., & Kubale Dvojmoč, V. (2019). Reptilian skin and its special histological structures. In C. S. Rutland, & V. Kubale Dvojmoč (Eds.), Veterinary anatomy and physiology (1-21). InTech. https://doi.org/10.5772/intechopen.84212

Reptilian skin is covered with scales forming armor that makes it watertight and enables reptiles to live on land in contrast to amphibians. An important part of the skin is the horny epidermis, with thick stratum corneum in which waxes are arranged... Read More about Reptilian skin and its special histological structures.

Veterinary anatomy and physiology (2019)
Book
Rutland, C. S., & Kubale Dvojmoč, V. (Eds.). (2019). Veterinary anatomy and physiology. InTech

Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the anima... Read More about Veterinary anatomy and physiology.

Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment (2019)
Journal Article
Al-Mayahy, M. H., Sabri, A. H., Rutland, C. S., Holmes, A., McKenna, J., Marlow, M., & Scurr, D. J. (2019). Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. European Journal of Pharmaceutics and Biopharmaceutics, 139, 33-43. https://doi.org/10.1016/j.ejpb.2019.02.006

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only li... Read More about Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment.

Introductory Chapter: Veterinary Anatomy and Physiology (2019)
Book Chapter
Kubale, V., Cousins, E., Bailey, C., El-Gendy, S. A., & Rutland, C. S. (2019). Introductory Chapter: Veterinary Anatomy and Physiology. In C. S. Rutland, & V. Kubale (Eds.), Veterinary anatomy and physiology (1-13). InTech. https://doi.org/10.5772/intechopen.82412

Mending a broken heart—the genetics of heart disease (2018)
Journal Article
Clark, N., Alibhai, A., & Rutland, C. S. (2018). Mending a broken heart—the genetics of heart disease. Frontiers for Young Minds, 6, Article 19. https://doi.org/10.3389/frym.2018.00019

Heart disease is a major cause of health problems worldwide. There are many different types of heart disease, but one that is fairly common and can have lots of negative side effects is called cardiomyopathy. We know that humans and many mammals, inc... Read More about Mending a broken heart—the genetics of heart disease.

Is Your Extra X Chromosome Holding You Back? An Insight into Female Education and Academic Careers in STEMM (2017)
Book Chapter
Alibhai, A., Saigar, M. M., Harding, E., & Rutland, C. S. (2017). Is Your Extra X Chromosome Holding You Back? An Insight into Female Education and Academic Careers in STEMM. In New pedagogical challenges in the 21st century. InTech. https://doi.org/10.5772/intechopen.71898

This review discusses whether gender inequality still exists within medical, scientific and engineering academia, with regards to the career development of academic staff. In the 1970s it was suggested that women who are talented and educated with fa... Read More about Is Your Extra X Chromosome Holding You Back? An Insight into Female Education and Academic Careers in STEMM.

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development (2017)
Journal Article
Ghosh, T. K., Aparicio-Sánchez, J. J., Buxton, S., Ketley, A., Mohamed, T., Rutland, C. S., …Brook, J. D. (2018). Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development. Journal of Molecular and Cellular Cardiology, 114, 185-198. https://doi.org/10.1016/j.yjmcc.2017.11.013

© 2017 Elsevier Ltd TBX5 plays a critical role in heart and forelimb development. Mutations in TBX5 cause Holt-Oram syndrome, an autosomal dominant condition that affects the formation of the heart and upper-limb. Several studies have provided signif... Read More about Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.

Peri-conception and first trimester diet modifies reproductive development in bulls (2017)
Journal Article
Copping, K. J., Ruiz-Diaz, M. D., Rutland, C. S., Mongan, N. P., Callaghan, M., McMillen, I. C., …Perry, V. (in press). Peri-conception and first trimester diet modifies reproductive development in bulls. Reproduction, Fertility and Development, https://doi.org/10.1071/RD17102

Nutritional perturbation during gestation alters male reproductive development in rodents and sheep. In cattle both the developmental trajectory of the feto–placental unit and its response to dietary perturbations is dissimilar to that of these speci... Read More about Peri-conception and first trimester diet modifies reproductive development in bulls.