3800 - Vet Science

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., …Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.

Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery (2022)
Journal Article
Simpson, S., Rizvanov, A. A., Jeyapalan, J. N., de Brot, S., & Rutland, C. S. (2022). Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. Frontiers in Veterinary Science, 9, Article 965391. https://doi.org/10.3389/fvets.2022.965391

Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs tha... Read More about Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery.

Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis (2022)
Journal Article
El‐Gendy, S. A., Alsafy, M. A., Rutland, C. S., Ez Elarab, S. M., Abd‐Elhafeez, H. H., & Kamal, B. M. (2023). Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis. Microscopy Research and Technique, 86(1), 53-62. https://doi.org/10.1002/jemt.24256

The present study describes the morphological characteristics of the camel heart Ossa cordis, and os aorta using computed tomography soft tissue window (CT) alongside 3D render volume reconstructions and light microscopy. The current study techniques... Read More about Ossa cordis and os aorta in the one‐humped camel: Computed tomography, light microscopy and morphometric analysis.

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer (2022)
Journal Article
Harris, A. E., Metzler, V. M., Lothion-Roy, J., Varun, D., Woodcock, C. L., Haigh, D. B., …Jeyapalan, J. N. (2022). Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Frontiers in Endocrinology, 13, Article 1006101. https://doi.org/10.3389/fendo.2022.1006101

Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic... Read More about Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer (2022)
Journal Article
Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., Metzler, V. M., Persson, J. L., …Mongan, N. P. (2022). The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers, 14(20), Article 5148. https://doi.org/10.3390/cancers14205148

Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing... Read More about The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.

Anatomy, histology, development and functions of Ossa cordis: A review (2022)
Journal Article
Best, A., Egerbacher, M., Swaine, S., Pérez, W., Alibhai, A., Rutland, P., …Rutland, C. S. (2022). Anatomy, histology, development and functions of Ossa cordis: A review. Anatomia, Histologia, Embryologia, 51(6), 683-695. https://doi.org/10.1111/ahe.12861

This systematic review highlights the similarities and variations in Ossa cordis prevalence, histology and anatomical location between differing veterinary species and in humans. In addition, it also identifies associated factors such as aging and ca... Read More about Anatomy, histology, development and functions of Ossa cordis: A review.

Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle (2022)
Book Chapter
Hall, J., Barker, E., Best, A., & Rutland, C. S. (2022). Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle. In C. Rutland, & S. El-Gendy (Eds.), Updates on Veterinary Anatomy and Physiology. InTech. https://doi.org/10.5772/intechopen.106576

Pericarditis in cattle can be classified as traumatic pericarditis (TP), idiopathic haemorrhagic, secondary to neoplasia or septic pericarditis due to haematogenous spread of organisms, such as Colibacilli or Pasturella. In cattle, pericardial diseas... Read More about Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle.

Artificial Microvesicles: New Perspective on Healing Tendon Wounds (2022)
Journal Article
Zakirova, E., Aimaletdinov, A., Mansurova, M., Titova, A., Kurilov, I., Rutland, C. S., …Rizvanov, A. (2022). Artificial Microvesicles: New Perspective on Healing Tendon Wounds. Cells Tissues Organs, 213(1), 24-39. https://doi.org/10.1159/000526845

Tendons have a limited capacity to repair both naturally and following clinical interventions. Damaged tissue often presents with structural and functional differences, adversely affecting animal performance, mobility, health, and welfare. Advances i... Read More about Artificial Microvesicles: New Perspective on Healing Tendon Wounds.

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