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Outputs (21)

Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis (2022)
Journal Article
El Sharazly, B. M., Aboul Asaad, I. A., Yassen, N. A., El Maghraby, G. M., Carter, W. G., Mohamed, D. A., Amer, B. S., & Ismail, H. I. (2023). Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis. Acta Tropica, 239, Article 106810. https://doi.org/10.1016/j.actatropica.2022.106810

Toxoplasmosis is a disease with a worldwide distribution and significant morbidity and mortality. In search of effective treatment, mefloquine (MQ) was repurposed and loaded with niosomes to treat acute and chronic phases of toxoplasmosis in experime... Read More about Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis.

The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019 (2022)
Journal Article
Naseem, A., Rasool, F., Ahmed, A., & Carter, W. G. (2023). The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019. Current Issues in Molecular Biology, 45(1), 12-32. https://doi.org/10.3390/cimb45010002

COVID-19 disease has had a global impact on human health with increased levels of morbidity and mortality. There is an unmet need to design and produce effective antivirals to treat COVID-19. This study aimed to explore the potential ability of natur... Read More about The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019.

The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study (2022)
Preprint / Working Paper
Jackson, C., Stewart, I., Plekhanova, T., Cunningham, P., Hazel, A. L., Al-Sheklly, B., Aul, R., Bolton, C. E., Chalder, T., Chalmers, J. D., Chaudhuri, N., Docherty, A. B., Donaldson, G., Edwardson, C. L., Elneima, O., Greening, N. J., Hanley, N. A., Harris, V. C., Harrison, E. M., Ho, L.-P., …Blaikley, J. F. The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study

Background

Sleep disturbance is common following hospitalisation both for COVID-19 and other causes. The clinical associations are poorly understood, despite it altering pathophysiology in other scenarios. We, therefore, investigated whether slee... Read More about The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study.

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men (2022)
Journal Article
Abdulla, H., Phillips, B., Wilkinson, D., Gates, A., Limb, M., Jandova, T., Bass, J., Lewis, J., Williams, J., Smith, K., Idris, I., & Atherton, P. (2023). Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men. Journal of Clinical Endocrinology and Metabolism, 108(4), 971-978. https://doi.org/10.1210/clinem/dgac613

Introduction
Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypot... Read More about Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

ABC of Clinical Reasoning (2022)
Book
Cooper, N., & Frain, J. (Eds.). (2022). ABC of Clinical Reasoning. Wiley-Blackwell

Being a good clinician is not only about knowledge ― how doctors and other healthcare professionals think, reason, and make decisions is arguably their most critical skill. The second edition of the ABC of Clinical Reasoning breaks down clinical reas... Read More about ABC of Clinical Reasoning.

Usability: An introduction to and literature review of usability testing for educational resources in radiation oncology (2022)
Journal Article
Keenan, H. L., Duke, S. L., Wharrad, H. J., Doody, G. A., & Patel, R. S. (2022). Usability: An introduction to and literature review of usability testing for educational resources in radiation oncology. Technical Innovations & Patient Support in Radiation Oncology, 24, 67-72. https://doi.org/10.1016/j.tipsro.2022.09.001

Usability, or the ease with which something can be used, is a key aspect in ensuring end-users can achieve the best possible outcomes from a given educational resource. Ideally usability testing should take place iteratively throughout the design of... Read More about Usability: An introduction to and literature review of usability testing for educational resources in radiation oncology.

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium (2022)
Journal Article
Smart, S. E., Agbedjro, D., Pardiñas, A. F., Ajnakina, O., Alameda, L., Andreassen, O. A., Barnes, T. R., Berardi, D., Camporesi, S., Cleusix, M., Conus, P., Crespo-Facorro, B., D'Andrea, G., Demjaha, A., Di Forti, M., Do, K., Doody, G., Eap, C. B., Ferchiou, A., Guidi, L., …MacCabe, J. H. (2022). Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium. Schizophrenia Research, 250, 1-9. https://doi.org/10.1016/j.schres.2022.09.009

Our aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and, secondly, to develop a parsimonious prediction model for TR. We combined data from ten prospec... Read More about Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium.

Motor unit dysregulation following 15 days of unilateral lower limb immobilisation (2022)
Journal Article
Inns, T. B., Bass, J. J., Hardy, E. J., Wilkinson, D. J., Stashuk, D. W., Atherton, P. J., Phillips, B. E., & Piasecki, M. (2022). Motor unit dysregulation following 15 days of unilateral lower limb immobilisation. Journal of Physiology, 600(21), 4753-4769. https://doi.org/10.1113/jp283425

Abstract: Disuse atrophy, caused by situations of unloading such as limb immobilisation, causes a rapid yet diverging reduction in skeletal muscle function when compared to muscle mass. While mechanistic insight into the loss of mass is well studied,... Read More about Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.

Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study (2022)
Journal Article
Mosanya, A. U., Ukoha-kalu, B. O., Isah, A., Umeh, I., Amorha, K. C., Ayogu, E. E., & Ubaka, C. (2022). Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study. PLoS ONE, 17(9), Article e0274638. https://doi.org/10.1371/journal.pone.0274638

Introduction
There is growing scientific evidence of mental and well-being issues that doctoral research students face as a result of not finishing their program on time. This study aims to explore the factors associated with the timely completion o... Read More about Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study.