Skip to main content

Research Repository

Advanced Search

Outputs (30)

Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence (2017)
Journal Article
Kruis, W., Kardalinos, V., Eisenbach, T., Lukas, M., Vich, T., Bunganic, I., …Spiller, R. (2017). Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence. Alimentary Pharmacology and Therapeutics, 46(3), 282-291. https://doi.org/10.1111/apt.14152

Background Previous studies have reached conflicting conclusions regarding the efficacy of mesalazine in the prevention of recurrent diverticulitis. Aim To investigate the efficacy and safety of mesalazine granules in the prevention of recur... Read More about Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence.

Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities (2016)
Journal Article
Hens, B., Corsetti, M., Spiller, R. C., Marciani, L., Vanuytsel, T., Tack, J., …Augustijns, P. (2017). Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519(1-2), https://doi.org/10.1016/j.ijpharm.2016.11.063

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables i... Read More about Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities.

Bowel Disorders (2016)
Journal Article
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016). Bowel Disorders. Gastroenterology, 150(6), 1393-1407.e5. https://doi.org/10.1053/j.gastro.2016.02.031

Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of func... Read More about Bowel Disorders.

Anticipation of thermal pain in diverticular disease (2016)
Journal Article
Smith, J. K., Marciani, L., Humes, D. J., Francis, S. T., Gowland, P. A., & Spiller, R. C. (2016). Anticipation of thermal pain in diverticular disease. Neurogastroenterology and Motility, 28(6), https://doi.org/10.1111/nmo.12790

Background The relative importance of peripheral nerve injury or differences in central pain processing in painful diverticular disease (DD) is unclear. Functional MRI has demonstrated changes in the anticipation of pain in irritable bowel syndrom... Read More about Anticipation of thermal pain in diverticular disease.

Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution (2015)
Journal Article
Khalaf, A., Hoad, C., Spiller, R. C., Gowland, P. A., Moran, G. W., & Marciani, L. (2015). Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution. World Journal of Gastrointestinal Pathophysiology, 6(4), https://doi.org/10.4291/wjgp.v6.i4.140

Magnetic resonance imaging (MRI) is a well established technique that has revolutionized diagnostic radiology. Until recently, the impact that MRI has had in the assessment of gastrointestinal motor function and bowel fluid distribution in health and... Read More about Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution.

Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults (2015)
Journal Article

Background: Intragastric creaming and droplet size of fat emulsions may affect intragastric behavior and gastrointestinal and satiety responses. Objectives: We tested the hypotheses that gastrointestinal physiologic responses and satiety will be i... Read More about Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults.