Outputs (48)

Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study (2021)
Journal Article
Alyami, A., Hoad, C. L., Tench, C., Bannur, U., Clarke, C., Latief, K., Argyriou, K., Lobo, A., Lung, P., Baldwin-Cleland, R., Sahnan, K., Hart, A., Limdi, J. K., McLaughlin, J., Atkinson, D., Parker, G. J. M., O’Connor, J. P. B., Little, R. A., Gowland, P. A., & Moran, G. W. (2021). Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study. Diagnostics, 11(11), Article 2135. https://doi.org/10.3390/diagnostics11112135

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potentia... Read More about Quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 T: A feasibility study.

Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies (2021)
Journal Article
Dellschaft, N., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2022). Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Alimentary Pharmacology and Therapeutics, 55(3), 327-338. https://doi.org/10.1111/apt.16673

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide dat... Read More about Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies.

Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging (2021)
Journal Article
O’Farrell, C., Hoad, C. L., Stamatopoulos, K., Marciani, L., Sulaiman, S., Simmons, M. J. H., & Batchelor, H. K. (2021). Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging. Pharmaceutics, 13(10), Article 1545. https://doi.org/10.3390/pharmaceutics13101545

Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us... Read More about Luminal fluid motion inside an in vitro dissolution model of the human ascending colon assessed using magnetic resonance imaging.

Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies (2021)
Journal Article
Gunn, D., Abbas, Z., Harris, H., Major, G., Hoad, C., Gowland, P., Marciani, L., Gill, S., Warren, F., Rossi, M., Remes-Troche, J., Whelan, K., & Spiller, R. (2022). Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies. Gut, 71(5), 919-927. https://doi.org/10.1136/gutjnl-2021-324784

Objective: Health promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), limiting their intake. Our aim was to test if co-administering psyllium with inulin would reduce gas... Read More about Psyllium reduces insulin-induced colonic gas production in irritable bowel syndrome: MRI and in vitro fermentation studies.

Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI (2021)
Journal Article
Sharif, H., Hoad, C. L., Abrehart, N., Gowland, P. A., Spiller, R. C., Kirkham, S., Loganathan, S., Papadopoulos, M., Benninga, M. A., Devadason, D., & Marciani, L. (2021). Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI. Diagnostics, 11(6), Article 974. https://doi.org/10.3390/diagnostics11060974

Background: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provid... Read More about Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.

Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls (2021)
Preprint / Working Paper
Dellschaft, N. S., Ng, C., Hoad, C., Marciani, L., Spiller, R., Stewart, I., Menys, A., Barr, H., Gowland, P. A., Major, G., & Smyth, A. R. Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls

Cystic fibrosis (CF) is a genetic disease affecting mucosal secretions. Most patients experience digestive symptoms, but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit using magn... Read More about Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls.

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article
Scott, R. A., Williams, H. G., Hoad, C. L., Alyami, A., Ortori, C. A., Grove, J. I., Marciani, L., Moran, G. W., Spiller, R. C., Menys, A., Aithal, G. P., & Gowland, P. A. (2021). MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability. Journal of Magnetic Resonance Imaging, 53(5), 1422-1431. https://doi.org/10.1002/jmri.27463

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation (2020)
Journal Article
Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., Burgell, R. E., Dimidi, E., Fikree, A., Ford, A. C., Fox, M., Hoad, C. L., Knowles, C. H., Krogh, K., Nugent, K., Remes-Troche, J. M., Whelan, K., & Corsetti, M. (2021). Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation. Neurogastroenterology and Motility, 33(6), 1-21. https://doi.org/10.1111/nmo.14050

Chronic constipation is a prevalent disorder that affects patients’ quality of life and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treat... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 1: Epidemiology, diagnosis, clinical associations, pathophysiology and investigation.

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants (2020)
Journal Article
Heissam, K., Abrehart, N., Hoad, C. L., Wright, J., Menys, A., Murray, K., Glover, P. M., Hebbard, G., Gowland, P. A., Baker, J., Hasler, W. L., Spiller, R. C., Corsetti, M., Brasseur, J. G., Hens, B., Shedden, K., Dickens, J., Mudie, D. M., Amidon, G. E., Amidon, G. L., & Marciani, L. (2020). Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants. PLoS ONE, 15(11), e0241441. https://doi.org/10.1371/journal.pone.0241441

Objective The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo dat... Read More about Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.

Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation (2020)
Journal Article
Sharif, H., Abrehart, N., Hoad, C., Murray, K., Perkins, A., Smith, M., Gowland, P., Spiller, R., Harris, R., Kirkham, S., Loganathan, S., Papadopoulos, M., Frost, K., Young Persons Advisory Group, Devadason, D., & Marciani, L. (2020). Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation. Journal of Pediatric Gastroenterology and Nutrition, 71(5), 604-611. https://doi.org/10.1097/MPG.0000000000002910

Objective: In England, 27,500 children are referred annually to hospital with constipation. An objective measure of whole gut transit time (WGTT) could aid management. The current standard WGTT assessment, the X-ray radiopaque marker (ROM) test, give... Read More about Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation.