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Outputs (30)

Clinical utility of reverse phase protein array for molecular classification of breast cancer (2015)
Journal Article
Negm, O. H., Muftah, A. A., Aleskandarany, M. A., Hamed, M. R., Ahmad, D. A., Nolan, C. C., Diez-Rodriguez, M., Tighe, P. J., Ellis, I. O., Rakha, E. A., & Green, A. R. (2016). Clinical utility of reverse phase protein array for molecular classification of breast cancer. Breast Cancer Research and Treatment, 155(1), 25-35. https://doi.org/10.1007/s10549-015-3654-2

Reverse Phase Protein Array (RPPA) represents a sensitive and high-throughput technique allowing simultaneous quantitation of protein expression levels in biological samples. This study aimed to confirm the ability of RPPA to classify archival formal... Read More about Clinical utility of reverse phase protein array for molecular classification of breast cancer.

Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: a case-control study (2015)
Journal Article
Verlaan, S., Aspray, T. J., Bauer, J. M., Cederholm, T., Hemsworth, J., Hill, T. R., McPhee, J. S., Piasecki, M., Seal, C., Sieber, C. C., ter Borg, S., Wijers, S. L., & Brandt, K. (2017). Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: a case-control study. Clinical Nutrition, 36(1), 267-274. https://doi.org/10.1016/j.clnu.2015.11.013

© 2015 The Authors Background & aim Sarcopenia, the age-related decrease in muscle mass, strength, and function, is a main cause of reduced mobility, increased falls, fractures and nursing home admissions. Cross-sectional and prospective studies indi... Read More about Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: a case-control study.

Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle (2015)
Journal Article
Franchi, M. V., Wilkinson, D. J., Quinlan, J. I., Mitchell, W. K., Lund, J. N., Williams, J. P., Reeves, N. D., Smith, K., Atherton, P. J., & Narici, M. V. (2015). Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle. Physiological Reports, 3(11), Article e12593. https://doi.org/10.14814/phy2.12593

We recently reported that the greatest distinguishing feature between eccentric (ECC) and concentric (CON) muscle loading lays in architectural adaptations: ECC favors increases in fascicle length (Lf), associated with distal vastus lateralis muscle... Read More about Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle.

Adverse drug reactions in Ghanaian children: review of reports from 2000 to 2012 in VigiBase (2015)
Journal Article
Cliff-Eribo, K. O., Choonara, I., Dodoo, A., Darko, D. M., & Sammons, H. (2015). Adverse drug reactions in Ghanaian children: review of reports from 2000 to 2012 in VigiBase. Expert Opinion on Drug Safety, https://doi.org/10.1517/14740338.2015.1096927

Objective: The aim of this article is to describe adverse drug reactions (ADRs) reported for children aged 0 - 17 years in Ghana.
Methods: Paediatric reports submitted by the Ghana National Centre for Pharmacovigilance to the World Health Organisati... Read More about Adverse drug reactions in Ghanaian children: review of reports from 2000 to 2012 in VigiBase.

Fulvestrant 500 mg Versus Anastrozole 1 mg for the First-Line Treatment of Advanced Breast Cancer: Overall Survival Analysis From the Phase II FIRST Study (2015)
Journal Article
Robertson, J., Ellis, M., Llombart-Cussac, A., Feltl, D., Dewar, J., Jasiówka, M., Hewson, N., & Rukazenkov, Y. (2015). Fulvestrant 500 mg Versus Anastrozole 1 mg for the First-Line Treatment of Advanced Breast Cancer: Overall Survival Analysis From the Phase II FIRST Study. Journal of Clinical Oncology, 33(32), 3781-3787. https://doi.org/10.1200/JCO.2015.61.5831

Purpose

To compare overall survival (OS) for fulvestrant 500 mg versus anastrozole as first-line endocrine therapy for advanced breast cancer.

Patients and Methods

The Fulvestrant First-Line Study Comparing Endocrine Treatments (FIRST) was a... Read More about Fulvestrant 500 mg Versus Anastrozole 1 mg for the First-Line Treatment of Advanced Breast Cancer: Overall Survival Analysis From the Phase II FIRST Study.

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status (2015)
Journal Article
Crossland, H., Sood, S., PHILLIPS, B., Gallagher, I. J., ATHERTON, P., Lunnon, K., Rullman, E., Keohane, A., Cederholm, T., Jensen, T., JC van Loon, L., Lannfelt, L., Kraus, W. E., Howard, R., Gustafsson, T., & Timmons, A. H. A. J. A. (2015). A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biology, 16(1), 1-17. https://doi.org/10.1186/s13059-015-0750-x

Background
Diagnostics of the human ageing process may help predict future healthcare needs or guide preventative measures for tackling diseases of older age. We take a transcriptomics approach to build the first reproducible multi-tissue RNA expres... Read More about A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status.

The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply (2015)
Journal Article
Mitchell, W. K., Phillips, B. E., Williams, J. P., Rankin, D., Lund, J. N., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2015). The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply. AJP - Endocrinology and Metabolism, 309(5), Article E450-E457. https://doi.org/10.1152/ajpendo.00112.2015

Essential amino acids (EAA) are responsible for skeletal muscle anabolic effects after nutrient intake. The pattern of appearance of EAA in blood, e.g., after intake of “slow” or “fast” protein sources or in response to grazing vs. bolus feeding patt... Read More about The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply.

Day-case closure of ileostomy: feasible, safe and efficient (2015)
Journal Article
Bhalla, A., Peacock, O., Tierney, G., Tou, S., Hurst, N., Speake, W., Williams, J. P., & Lund, J. N. (2015). Day-case closure of ileostomy: feasible, safe and efficient. Colorectal Disease, 17(9), https://doi.org/10.1111/codi.12961

Aim

Over 5000 loop ileostomy closures were performed in the UK in 2013 with a median inpatient stay of 5 days. Previously we have successfully implemented a 23-h protocol for loop ileostomy closure which was modified for same-day discharge. We pre... Read More about Day-case closure of ileostomy: feasible, safe and efficient.