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Adverse drug reactions in Ghanaian children: review of reports from 2000 to 2012 in VigiBase

Cliff-Eribo, Kennedy Obebi; Choonara, Imti; Dodoo, Alex; Darko, Delese M.; Sammons, Helen

Authors

Kennedy Obebi Cliff-Eribo mzxkoc@nottingham.ac.uk

Imti Choonara imti.choonara@nottingham.ac.uk

Alex Dodoo

Delese M. Darko

Helen Sammons helen.sammons@nottingham.ac.uk



Abstract

Objective: The aim of this article is to describe adverse drug reactions (ADRs) reported for children aged 0 - 17 years in Ghana.
Methods: Paediatric reports submitted by the Ghana National Centre for Pharmacovigilance to the World Health Organisation (WHO) Global ADR database, VigiBase up to December 2012 were extracted. The data were analysed for number of reports per year, types of reporters and suspected ADRs and drugs.
Results: A total of 343 reports for children were received during the period. The drug classes most frequently reported were vaccines (115, 31%), antimalarials (106, 28%) and antibiotics (57, 15%). Of the top 20 individual drugs, 19 were anti-infectives. The most frequently reported ADRs were injection site infection, fever and rash. There were 23 deaths reported, and antimalarials were implicated in 12 cases.
Conclusions: Vaccines, antimalarials and antibiotics are the leading medicines reported to cause ADRs in Ghanaian children. There was a high mortality rate, with many of the deaths due to causes explained in the individual case safety reports.

Journal Article Type Article
Publication Date Oct 5, 2015
Journal Expert Opinion on Drug Safety
Print ISSN 1474-0338
Electronic ISSN 1744-764X
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
APA6 Citation Cliff-Eribo, K. O., Choonara, I., Dodoo, A., Darko, D. M., & Sammons, H. (2015). Adverse drug reactions in Ghanaian children: review of reports from 2000 to 2012 in VigiBase. Expert Opinion on Drug Safety, doi:10.1517/14740338.2015.1096927
DOI https://doi.org/10.1517/14740338.2015.1096927
Keywords adverse drug reactions, spontaneous reporting system, pharmacovigilance, drug safety, children
Publisher URL http://www.tandfonline.com/doi/full/10.1517/14740338.2015.1096927
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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