Outputs (16)

Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative (2020)
Journal Article
Extermann, M., Brain, . E., Canin, B., Cherian, . M. N., Cheung, K. L., de Glas, N., Devi, B., Hamaker, M., Kanesvaran, R., Karnakis, T., Kenis, C., Musolino, N., O'Donovan, A., Soto-Perez-de-Celis, E., Steer, C., & Wildiers, . H. (2021). Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative. Lancet Oncology, 22(1), e29-e36. https://doi.org/10.1016/S1470-2045%2820%2930473-3

In 2011, the International Society of Geriatric Oncology (SIOG) published the SIOG 10 Priorities Initiative, which defined top priorities for the improvement of the care of older adults with cancer worldwide.1 Substantial scientific, clinical, and ed... Read More about Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative.

Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer (2020)
Journal Article
Battisti, N. M. L., Reed, M. W., Herbert, E., Morgan, J. L., Collins, K. A., Ward, S. E., Holmes, G. R., Bradburn, M., Walters, S. J., Burton, M., Lifford, K., Edwards, A., Robinson, T. G., Martin, C., Chater, T., Pemberton, K. J., Shrestha, A., Brennan, A., Cheung, K. L., Todd, A., …Ring, A. (2021). Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer. European Journal of Cancer, 144, 269-280. https://doi.org/10.1016/j.ejca.2020.11.022

Introduction: Older patients with early breast cancer (EBC) derive modest survival benefit from chemotherapy but have increased toxicity risk. Data on the impact of chemotherapy for EBC on quality of life in older patients are limited, but this is a... Read More about Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer.

Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray (2020)
Journal Article
Parks, R. M., Albanghali, M. A., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2021). Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray. Breast Cancer Research and Treatment, 185(3), 647-655. https://doi.org/10.1007/s10549-020-06023-4

© 2020, The Author(s). Purpose: Prediction of response to primary endocrine therapy (PET) in older women is based on measurement of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor (HER)-2. This study uses a uniq... Read More about Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray.

Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life (2020)
Journal Article
Wyld, L., Reed, M. W., Morgan, J., Collins, K., Ward, S., Holmes, G. R., Bradburn, M., Walters, S., Burton, M., Herbert, E., Lifford, K., Edwards, A., Ring, A., Robinson, T., Martin, C., Chater, T., Pemberton, K., Shrestha, A., Brennan, A., Cheung, K. L., …Thomson, A. M. (2021). Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life. European Journal of Cancer, 142, 48-62. https://doi.org/10.1016/j.ejca.2020.10.015

Background: Age-related breast cancer treatment variance is widespread with many older women having primary endocrine therapy (PET), which may contribute to inferior survival and local control. This propensity-matched study determined if a subgroup o... Read More about Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life.

Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial (2020)
Journal Article
Todd, A., Martin, C., Morgan, J., Herbert, E., Bradburn, M., Burton, M., Reed, M. W., Chater, T., Pemberton, K., Walters, S., Cheung, K. L., Audisio, R. A., Ring, A., Robinson, T., Green, T., Gath, J., & Wyld, L. (2021). Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial. Journal of Geriatric Oncology, 12(5), 714-723. https://doi.org/10.1016/j.jgo.2020.10.015

Introduction
Recruitment and retention are two of the most important factors in successfully running clinical trials. Many trials encounter problems with both, causing delays or preventing study progress. These issues are greater in older adults and... Read More about Age specific recruitment and retention to a large multicentre observational breast cancer trial in older women: The Age Gap Trial.

The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer (2020)
Journal Article
Chan, W. L., Ma, T., Cheung, K. L., Choi, H., Wong, J., Lam, K. O., Yuen, K. K., Luk, M. Y., & Kwong, D. (2021). The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer. Journal of Geriatric Oncology, 12(4), 557-562. https://doi.org/10.1016/j.jgo.2020.10.013

Introduction: Older patients experience a higher risk of treatment-related toxicity (TRT). The G8 screening tool was developed to separate cancer older patients fit to receive standard treatment from those who are frail and experiencing functional de... Read More about The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer.

Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer (2020)
Journal Article
Morgan, J. L., Holmes, G., Ward, S., Martin, C., Burton, M., Walters, S. J., Cheung, K. L., Audisio, R. A., Reed, M. W., Wyld, L., Lifford, K., Edwards, A., Brain, K., Ring, A., Robinson, T., Chater, T., Pemberton, K., Shrestha, A., Nettleship, A., Richards, P., …Parmeshwar, R. (2021). Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer. EJSO - European Journal of Surgical Oncology, 47(2), 261-268. https://doi.org/10.1016/j.ejso.2020.09.029

© 2020 The Authors Background: In the UK there is variation in the treatment of older women with breast cancer, with up to 40% receiving primary endocrine therapy (PET), which is associated with inferior survival. Case mix and patient choice may expl... Read More about Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer.

The care of older cancer patients in the United Kingdom (2020)
Journal Article
Gomes, F., Lewis, A., Morris, R., Parks, R., Kalsi, T., Babic-Illamn, G., Baxter, M., Colquhoun, K., Rodgers, L., Smith, E., Greystoke, A., Bayman, N., Cree, A., Ng, C., de Liguori Carino, N., Basile, S., Moore, J., Merchant, Z., Swinson, D., Parbhoo, A., …Simcock, R. (2020). The care of older cancer patients in the United Kingdom. ecancermedicalscience, 14, Article 1101. https://doi.org/10.3332/ECANCER.2020.1101

The ageing population poses new challenges globally. Cancer care for older patients is one of these challenges, and it has a significant impact on societies. In the United Kingdom (UK), as the number of older cancer patients increases, the management... Read More about The care of older cancer patients in the United Kingdom.

Clinical relevance of biomarkers in oestrogen receptor positive breast cancer (2020)
Book Chapter
Parks, R. M., & Cheung, K. L. (2020). Clinical relevance of biomarkers in oestrogen receptor positive breast cancer. In G. G. Chen, M. C. Tong, & C. van Hasselt (Eds.), Estrogen receptors: structure, functions and clinical aspects (53-91). Nova Science Publishers

© 2020 Nova Science Publishers, Inc. Some biomarkers have been examined extensively in the context of breast cancer, including the oestrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). They are now routinely measured and used c... Read More about Clinical relevance of biomarkers in oestrogen receptor positive breast cancer.

Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome (2020)
Journal Article
Parks, R. M., Albanghali, M., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2020). Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome. Cancers, 12(8), Article 2067. https://doi.org/10.3390/cancers12082067

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The majority of biological profiling studies use surgical excision (SE) samples, excluding patients receiving nonsurgical and neoadjuvant therapy. We propose using core needle biopsy (CNB) for... Read More about Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome.