Outputs (38)

Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis (2022)
Journal Article
Gwinnutt, J. M., Norton, S., Hyrich, K. L., Lunt, M., Combe, B., Rincheval, N., Ruyssen‐Witrand, A., Fautrel, B., McWilliams, D. F., Walsh, D. A., Nikiphorou, E., Kiely, P. D., Young, A., Chipping, J. R., MacGregor, A., & Verstappen, S. M. (2023). Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis. Arthritis Care and Research, 75(5), 1026-1035. https://doi.org/10.1002/acr.24996

Objective: To investigate how social support, financial status, and lifestyle influence the development of excess disability in rheumatoid arthritis (RA). Methods: Data were obtained from the Étude et Suivi des Polyarthrites Indifférenciées Récentes... Read More about Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis.

Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD) (2022)
Journal Article
Georgopoulos, V., Smith, S., McWilliams, D. F., Steultjens, M. P. M., Williams, A., Price, A., Valdes, A. M., Vincent, T. L., Watt, F. E., & Walsh, D. A. (2023). Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD). Osteoarthritis and Cartilage, 31(1), 83-95. https://doi.org/10.1016/j.joca.2022.08.011

Objective: In order to facilitate data pooling between studies, we explored harmonisation of patient-reported outcome measures (PROMs) in people with knee pain due to osteoarthritis or knee trauma, using the Patient Acceptable Symptom State scores (P... Read More about Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD).

An observational study of centrally facilitated pain in individuals with chronic low back pain (2022)
Journal Article
Georgopoulos, V., Akin-Akinyosoye, K., Smith, S., McWilliams, D. F., Hendrick, P., & Walsh, D. A. (2022). An observational study of centrally facilitated pain in individuals with chronic low back pain. PAIN Reports, 7(3), Article e1003. https://doi.org/10.1097/PR9.0000000000001003

Central pain facilitation can hinder recovery in people with chronic low back pain (CLBP). The aim of this observational study was to investigate whether indices of centrally facilitated pain are associated with pain outcomes in a hospital-based coho... Read More about An observational study of centrally facilitated pain in individuals with chronic low back pain.

Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain (2022)
Presentation / Conference Contribution
Habib, M., Smith, S., Chaplin, W., Millar, B., McWilliams, D., & Walsh, D. Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain. Presented at Osteoarthritis Research Society International (OARSI), Berlin

Purpose: Pain is the primary clinical manifestation in individuals with osteoarthritis (OA). It is an unpleasant and distressing experience, particularly during weight-bearing activities, inhibiting activity, and reducing quality of life. Two groups... Read More about Central pain mechanisms predict physical inactivity at 1-year in individuals with knee pain.

Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis (2022)
Journal Article
Gwinnutt, J. M., Norton, S., Hyrich, K. L., Lunt, M., Combe, B., Rincheval, N., Ruyssen-Witrand, A., Fautrel, B., McWilliams, D. F., Walsh, D. A., Nikiphorou, E., Kiely, P., Young, A., Chipping, J. R., MacGregor, A., & Verstappen, S. M. (2022). Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis. Rheumatology, 61(12), 4687–4701. https://doi.org/10.1093/rheumatology/keac137

OBJECTIVES: To identify groups of people with RA with different disability trajectories over 10 years, despite comparable levels of inflammation. METHODS: Data for this analysis came from three European prospective cohort studies of people with RA [N... Read More about Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis.

Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network (2021)
Journal Article
Ifesemen, O. S., McWilliams, D. F., Norton, S., Kiely, P. D. W., Young, A., & Walsh, D. A. (2022). Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network. Rheumatology, 61(9), 3737-3745. https://doi.org/10.1093/rheumatology/keab947

OBJECTIVES: Fatigue is a disabling symptom in people with RA. This study aims to describe the prevalence, risk factors and longitudinal course of fatigue in early RA. METHODS: Demographic, clinical, quality of life (QoL), comorbidities and laboratory... Read More about Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network.

A Systematic Review of the Biological Effects of Cordycepin (2021)
Journal Article
Radhi, M., Ashraf, S., Lawrence, S., Tranholm, A. A., Wellham, P. A. D., Hafeez, A., Khamis, A. S., Thomas, R., McWilliams, D., & De Moor, C. H. (2021). A Systematic Review of the Biological Effects of Cordycepin. Molecules, 26(19), Article 5886. https://doi.org/10.3390/molecules26195886

We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 Fe... Read More about A Systematic Review of the Biological Effects of Cordycepin.

The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis (2021)
Journal Article
McWilliams, D. F., Thankaraj, D., Jones-Diette, J., Morgan, R., Ifesemen, O. S., Shenker, N. G., & Walsh, D. A. (2022). The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis. Rheumatology, 61(1), 76-89. https://doi.org/10.1093/rheumatology/keab503

Objectives: Glucocorticosteroids (GCs) are recommended to suppress inflammation in people with active RA. This systematic review and meta-analysis aimed to quantify the effects of systemic GCs on RA pain. Methods: A systematic literature review of ra... Read More about The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis.

Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study (2021)
Journal Article
Ifesemen, O., McWilliams, D. F., Ferguson, E., Wakefield, R., Akin-Akinyosoye, K., Wilson, D., Platts, D., Ledbury, S., & Walsh, D. A. (2021). Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study. BMC Rheumatology, 5(1), Article 23. https://doi.org/10.1186/s41927-021-00187-2

Background: Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study aims to validate a self-repor... Read More about Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study.

The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis (2021)
Presentation / Conference Contribution
Georgopoulos, V., Smith, S., McWilliams, D., Vincent, T., Watt, F., & Walsh, D. The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis. Presented at Osteoarthritis Society International World Congress, Virtual

Purpose: Knee pain is highly prevalent, most commonly attributed to osteoarthritis in older people, and in younger people often due to internal derangements. Knee pain can be measured using numerical patient-reported outcome measures (PROMs). Several... Read More about The patient acceptable symptom state for knee pain - a systematic literature review and meta-analysis.