Outputs (3)

Molecular and structural basis for Lewis glycan recognition by a cancer-targeting antibody (2020)
Journal Article
Soliman, C., Guy, A. J., Chua, J. X., Vankemmelbeke, M., McIntosh, R. S., Eastwood, S., Truong, V. K., Elbourne, A., Spendlove, I., Durrant, L. G., & Ramsland, P. A. (2020). Molecular and structural basis for Lewis glycan recognition by a cancer-targeting antibody. Biochemical Journal, 477(17), 3219-3235. https://doi.org/10.1042/bcj20200454

Immunotherapy has been successful in treating many tumour types. The development of additional tumour-antigen binding monoclonal antibodies (mAbs) will help expand the range of immunotherapeutic targets. Lewis histo-blood group and related glycans ar... Read More about Molecular and structural basis for Lewis glycan recognition by a cancer-targeting antibody.

Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis (2020)
Journal Article
Aram, J., Frakich, N., Morandi, E., Alrouji, M., Samaraweera, A., Onion, D., Spendlove, I., Colombo, S. L., Tanasescu, R., Gran, B., & Constantinescu, C. S. (2020). Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis. Biomedicines, 8(7), Article 226. https://doi.org/10.3390/BIOMEDICINES8070226

© 2020 by the authors. Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis. We investi... Read More about Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis.

Engineering the Human Fc Region Enables Direct Cell Killing by Cancer Glycan-Targeting Antibodies without the Need for Immune Effector Cells or Complement (2020)
Journal Article
Vankemmelbeke, M., McIntosh, R. S., Chua, J. X., Kirk, T., Daniels, I., Patsalidou, M., Moss, R., Parsons, T., Scott, D., Harris, G., Ramage, J. M., Spendlove, I., & Durrant, L. G. (2020). Engineering the Human Fc Region Enables Direct Cell Killing by Cancer Glycan-Targeting Antibodies without the Need for Immune Effector Cells or Complement. Cancer Research, 80(16), 3399-3412. https://doi.org/10.1158/0008-5472.CAN-19-3599

©2020 American Association for Cancer Research. Murine IgG3 glycan-targeting mAb often induces direct cell killing in the absence of immune effector cells or complement via a proinflammatory mechanism resembling oncotic necrosis. This cancer cell kil... Read More about Engineering the Human Fc Region Enables Direct Cell Killing by Cancer Glycan-Targeting Antibodies without the Need for Immune Effector Cells or Complement.