Outputs (114)

Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis (2022)
Journal Article
Meaton, I., Altokhis, A., Allen, C. M., Clarke, M. A., Sinnecker, T., Meier, D., …Evangelou, N. (2022). Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis. Multiple Sclerosis Journal, https://doi.org/10.1177/13524585221118677

Background: White matter lesions (WMLs) on brain magnetic resonance imaging (MRI) in multiple sclerosis (MS) may contribute to misdiagnosis. In chronic active lesions, peripheral iron-laden macrophages appear as paramagnetic rim lesions (PRLs). Objec... Read More about Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis.

The role of temporal coherence and temporal predictability in the build-up of auditory grouping (2022)
Journal Article
Sollini, J., Poole, K. C., Blauth-Muszkowski, D., & Bizley, J. K. (2022). The role of temporal coherence and temporal predictability in the build-up of auditory grouping. Scientific Reports, 12, Article 14493. https://doi.org/10.1038/s41598-022-18583-0

The cochlea decomposes sounds into separate frequency channels, from which the auditory brain must reconstruct the auditory scene. To do this the auditory system must make decisions about which frequency information should be grouped together, and wh... Read More about The role of temporal coherence and temporal predictability in the build-up of auditory grouping.

Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study (2022)
Journal Article
Spencer, S., Mielczarek, M., Olszewski, J., Sereda, M., Joossen, I., Vermeersch, H., …Michiels, S. (2022). Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study. Frontiers in Neuroscience, 16, Article 971633. https://doi.org/10.3389/fnins.2022.971633

Background: Tinnitus is a common symptom, affecting about 10–15% of the adult population. When input from the somatosensory system can influence and/or elicit tinnitus, this type of subjective tinnitus is called somatosensory tinnitus. Recently, a ne... Read More about Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study.

Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis (2022)
Journal Article
Altokhis, A. I., Hibbert, A. M., Allen, C. M., Mougin, O., Alotaibi, A., Lim, S. Y., …Evangelou, N. (2022). Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis. Multiple Sclerosis Journal, 28(14), 2202-2211. https://doi.org/10.1177/13524585221114750

Background: Iron rims (IRs) surrounding white matter lesions (WMLs) are suggested to predict a more severe disease course. Only small longitudinal cohorts of patients with and without iron rim lesions (IRLs) have been reported so far. Objective: To a... Read More about Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis.

Audiological biomarkers of tinnitus in an older Portuguese population (2022)
Journal Article
Haider, H. F., Ribeiro, D., Ribeiro, S. F., Trigueiros, N., Caria, H., Borrego, L., …Paço, J. (2022). Audiological biomarkers of tinnitus in an older Portuguese population. Frontiers in Aging Neuroscience, 14, Article 933117. https://doi.org/10.3389/fnagi.2022.933117

Tinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated asso... Read More about Audiological biomarkers of tinnitus in an older Portuguese population.

Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study (2022)
Journal Article
Kurien, T., Kerslake, R. W., Graven‐Nielsen, T., Arendt‐Nielsen, L., Auer, D. P., Edwards, K., …Petersen, K. K. (2022). Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study. European Journal of Pain, 26(9), 1979-1989. https://doi.org/10.1002/ejp.2018

Background: A subset of osteoarthritis patients will experience chronic postoperative pain after total knee arthroplasty (TKA), but the source of pain is unclear. The aim of this exploratory study was to assess patients with and without postoperative... Read More about Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study.

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review (2022)
Journal Article
Markus, H. S., Van Der Flier, W. M., Smith, E. E., Bath, P., Biessels, G. J., Briceno, E., …Dichgans, M. (2022). Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review. JAMA Neurology, https://doi.org/10.1001/jamaneurol.2022.2262

Importance: Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease me... Read More about Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study (2022)
Journal Article
Ellis, R., Laviola, M., Stolady, D., Valentine, R. L., Pillai, A., & Hardman, J. G. (2022). Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study. British Journal of Anaesthesia, 129(4), 581-587. https://doi.org/10.1016/j.bja.2022.06.021

Background
Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to... Read More about Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study.

The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack (2022)
Journal Article
McDermott, J. H., Leach, M., Sen, D., Smith, C. J., Newman, W. G., & Bath, P. M. (2022). The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack. Expert Review of Clinical Pharmacology, 15, 811-825. https://doi.org/10.1080/17512433.2022.2108401

Introduction: Clopidogrel is an antiplatelet agent recommended for secondary prevention of ischemic stroke (IS) and transient ischemic attack (TIA). Conversion of clopidogrel to its active metabolite by hepatic cytochrome P450-2C19 (CYP2C19) is essen... Read More about The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack.

Opt-in HIV testing in construction workplaces: an exploration of its suitability, using the socioecological framework (2022)
Journal Article
Somerset, S., Jones, W., Evans, C., Cirelli, C., Mbang, D., & Blake, H. (2022). Opt-in HIV testing in construction workplaces: an exploration of its suitability, using the socioecological framework. BMC Public Health, 22(1), Article 1409. https://doi.org/10.1186/s12889-022-13787-5

Background: Late diagnosis of HIV remains a challenge, despite improved testing and treatment. Testing is often targeted at high-risk groups; workplace events might normalise testing and allow access to a wider population. The construction workforce... Read More about Opt-in HIV testing in construction workplaces: an exploration of its suitability, using the socioecological framework.