Outputs (114)

Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis (2022)
Journal Article

Background: White matter lesions (WMLs) on brain magnetic resonance imaging (MRI) in multiple sclerosis (MS) may contribute to misdiagnosis. In chronic active lesions, peripheral iron-laden macrophages appear as paramagnetic rim lesions (PRLs). Objec... Read More about Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis.

The role of temporal coherence and temporal predictability in the build-up of auditory grouping (2022)
Journal Article

The cochlea decomposes sounds into separate frequency channels, from which the auditory brain must reconstruct the auditory scene. To do this the auditory system must make decisions about which frequency information should be grouped together, and wh... Read More about The role of temporal coherence and temporal predictability in the build-up of auditory grouping.

Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study (2022)
Journal Article

Background: Tinnitus is a common symptom, affecting about 10–15% of the adult population. When input from the somatosensory system can influence and/or elicit tinnitus, this type of subjective tinnitus is called somatosensory tinnitus. Recently, a ne... Read More about Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study.

Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis (2022)
Journal Article

Background: Iron rims (IRs) surrounding white matter lesions (WMLs) are suggested to predict a more severe disease course. Only small longitudinal cohorts of patients with and without iron rim lesions (IRLs) have been reported so far. Objective: To a... Read More about Longitudinal clinical study of patients with iron rim lesions in multiple sclerosis.

Audiological biomarkers of tinnitus in an older Portuguese population (2022)
Journal Article

Tinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated asso... Read More about Audiological biomarkers of tinnitus in an older Portuguese population.

Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study (2022)
Journal Article

Background: A subset of osteoarthritis patients will experience chronic postoperative pain after total knee arthroplasty (TKA), but the source of pain is unclear. The aim of this exploratory study was to assess patients with and without postoperative... Read More about Chronic postoperative pain after total knee arthroplasty: The potential contributions of synovitis, pain sensitization and pain catastrophizing—An explorative study.

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review (2022)
Journal Article

Importance: Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease me... Read More about Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study (2022)
Journal Article

Background Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to... Read More about Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study.

The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack (2022)
Journal Article

Introduction: Clopidogrel is an antiplatelet agent recommended for secondary prevention of ischemic stroke (IS) and transient ischemic attack (TIA). Conversion of clopidogrel to its active metabolite by hepatic cytochrome P450-2C19 (CYP2C19) is essen... Read More about The role of CYP2C19 genotyping to guide antiplatelet therapy following ischemic stroke or transient ischemic attack.

Evaluation of opt-in HIV testing in the construction workplace using the socioecological framework (2022)
Journal Article

Background Late diagnosis of HIV remains a challenge and the construction workforce has several risk factors for HIV. In the Test@Work programme, we delivered HIV tests embedded within a general health check to construction workers, with high uptake... Read More about Evaluation of opt-in HIV testing in the construction workplace using the socioecological framework.