Outputs (26)

Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation (2020)
Journal Article
Scott, T. E., Das, A., Haque, M., Bates, D. G., & Hardman, J. G. (2020). Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation. Intensive Care Medicine Experimental, 8(1), Article 26. https://doi.org/10.1186/s40635-020-00314-2

Background

Primary blast lung injury (PBLI) presents as a syndrome of respiratory distress and haemoptysis resulting from explosive shock wave exposure and is a frequent cause of mortality and morbidity in both military conflicts and terrorist att... Read More about Management of primary blast lung injury: a comparison of airway pressure release versus low tidal volume ventilation.

Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study (2020)
Journal Article
Hewson, D. W., Knudsen, R., Shanmuganathan, S., Ferguson, E., Hardman, J. G., Bedforth, N. M., & McCahon, R. A. (2020). Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study. British Journal of Anaesthesia, 125(2), 168-174. https://doi.org/10.1016/j.bja.2020.04.090

Background: The effect of mental rotation training on ultrasound guided regional anaesthesia (UGRA) skill acquisition is currently unknown. In this study we aimed to examine whether mental rotation skill training can improve UGRA task performance by... Read More about Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study.

Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study (2020)
Journal Article
Hewson, D. W., Knudsen, R., Shanmuganathan, S., Ferguson, E., Hardman, J. G., Bedforth, N. M., & McCahon, R. A. (2020). Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study. British Journal of Anaesthesia, 125(2), 168-174. https://doi.org/10.1016/j.bja.2020.04.090

© 2020 British Journal of Anaesthesia Background: The effect of mental rotation training on ultrasound-guided regional anaesthesia (UGRA) skill acquisition is currently unknown. In this study we aimed to examine whether mental rotation skill training... Read More about Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study.

Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation (2020)
Journal Article
Yehya, N., Saffaran, S., Das, A., Hardman, J. G., Laffey, J. G., & Bates, D. G. (2020). Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation. Critical Care Medicine, 48(7), 1001-1008. https://doi.org/10.1097/CCM.0000000000004372

Objectives:
Mechanical power and driving pressure have been proposed as indicators, and possibly drivers, of ventilator-induced lung injury. We tested the utility of these different measures as targets to derive maximally protective ventilator sett... Read More about Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation.

Effect of oxygen fraction on airway rescue: a computational modelling study (2020)
Journal Article
Laviola, M., Niklas, C., Das, A., Bates, D. G., & Hardman, J. G. (2020). Effect of oxygen fraction on airway rescue: a computational modelling study. British Journal of Anaesthesia, 125(1), e69-e74. https://doi.org/10.1016/j.bja.2020.01.004

© 2020 British Journal of Anaesthesia Background: During induction of general anaesthesia, patients frequently experience apnoea, which can lead to dangerous hypoxaemia. An obstructed upper airway can impede attempts to provide ventilation. Although... Read More about Effect of oxygen fraction on airway rescue: a computational modelling study.

Mathematical and Computational Modelling in Critical Illness (2019)
Journal Article
Laviola, M., Bates, D. G., & Hardman, J. G. (2019). Mathematical and Computational Modelling in Critical Illness. European Respiratory & Pulmonary Diseases, 5(1),

Mathematical and computational modelling are assuming a prominent role in investigating the complex pathophysiological states and therapeutic strategies in critical illness. This editorial briefly illustrates the models of the respiratory and cardiov... Read More about Mathematical and Computational Modelling in Critical Illness.

High oxygen fraction during airway opening is key to effective airway rescue in obese subjects (2019)
Presentation / Conference Contribution
Laviola, M., Christian, N., Alahmadi, H., Das, A., Bates, D. G., & Hardman, J. G. (2019, July). High oxygen fraction during airway opening is key to effective airway rescue in obese subjects. Presented at 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Berlin, Germany

Apnea is common after induction of anesthesia and may produce dangerous hypoxemia, particularly in obese subjects. Optimal management of airway emergencies in obese, apneic subjects is complex and controversial, and clinical studies of rescue strateg... Read More about High oxygen fraction during airway opening is key to effective airway rescue in obese subjects.

Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea (2018)
Journal Article
Laviola, M., Das, A., Chikhani, M., Bates, D., & Hardman, J. (2019). Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea. British Journal of Anaesthesia, 122(3), 395-401. https://doi.org/10.1016/j.bja.2018.11.012

Background

Apnoeic oxygenation can come close to matching the oxygen demands of the apnoeic patient but does not facilitate carbon dioxide (CO2) elimination, potentially resulting in dangerous hypercapnia. Numerous studies have shown that high-flo... Read More about Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea.

Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia (2018)
Journal Article
Shafqat, A., Rafi, M., Thanawala, V., Bedforth, N. M., Hardman, J., & McCahon, R. A. (2018). Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia. British Journal of Anaesthesia, 121(4), 867-875. https://doi.org/10.1016/j.bja.2018.06.014

Background: We aimed to examine the validity and reliability of previously developed criterion-referenced assessment checklist (AC) and global rating scale (GRS) to assess performance in ultrasound-guided regional anaesthesia (UGRA).
Methods: Twenty... Read More about Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia.

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., Morgan, S., & Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, 3(4), 257-262. https://doi.org/10.1002/lio2.168

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.