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Outputs (488)

Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: A multi-site study (2020)
Journal Article
Grist, J. T., Withey, S., MacPherson, L., Oates, A., Powell, S., Novak, J., Abernethy, L., Pizer, B., Grundy, R., Bailey, S., Mitra, D., Arvanitis, T. N., Auer, D. P., Avula, S., & Peet, A. C. (2020). Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: A multi-site study. NeuroImage: Clinical, 25, Article 102172. https://doi.org/10.1016/j.nicl.2020.102172

The imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance imaging playing a key role in providing tumour specific imaging information. Diffusion weighted and perfusion imaging... Read More about Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: A multi-site study.

Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials (2020)
Journal Article
Walker, D. A., Meijer, L., Coyle, B., & Halsey, C. (2020). Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials. Lancet Child and Adolescent Health, 4(3), 242-250. https://doi.org/10.1016/s2352-4642%2819%2930333-5

Leptomeningeal malignancy complicates childhood cancers, including leukaemias, brain tumours, and solid tumours. In leukaemia, such malignancy is thought to invade leptomeninges via the vascular route. In brain tumours, dissemination from the primary... Read More about Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials.

The test accuracy of antenatal ultrasound definitions of fetal macrosomia to predict birth injury: a systematic review (2020)
Journal Article
Robinson, R., Walker, K. F., White, V. A., Bugg, G. J., Snell, K. I., & Jones, N. W. (2020). The test accuracy of antenatal ultrasound definitions of fetal macrosomia to predict birth injury: a systematic review. European Journal of Obstetrics and Gynecology and Reproductive Biology, 246, P79-85. https://doi.org/10.1016/j.ejogrb.2020.01.019

Objectives
To determine which ultrasound measurement for predicted fetal macrosomia most accurately predicts adverse delivery and neonatal outcomes.

Study Design
Four biomedical databases searched for studies published after 1966.
Randomised tr... Read More about The test accuracy of antenatal ultrasound definitions of fetal macrosomia to predict birth injury: a systematic review.

Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study (2019)
Journal Article
Li, B. K., Vasiljevic, A., Dufour, C., Yao, F., Ho, B. L. B., Lu, M., Hwang, E. I., Gururangan, S., Hansford, J. R., Fouladi, M., Nobusawa, S., Laquerriere, A., Delisle, M.-B., Fangusaro, J., Forest, F., Toledano, H., Solano-Paez, P., Leary, S., Birks, D., Hoffman, L. M., …Jouvet, A. (2020). Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study. Acta Neuropathologica, 139(2), 223–241. https://doi.org/10.1007/s00401-019-02111-y

Pineoblastomas (PBs) are rare, aggressive pediatric brain tumors of the pineal gland with modest overall survival despite intensive therapy. We sought to define the clinical and molecular spectra of PB to inform new treatment approaches for this orph... Read More about Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study.

Systematic review: measurement properties of patient-reported outcome measures evaluated with childhood brain tumor survivors or other acquired brain injury (2019)
Journal Article
Bull, K. S., Hornsey, S., Kennedy, C. R., Darlington, A.-S. E., Grootenhuis, M. A., Hargrave, D., Liossi, C., Shepherd, J. P., Walker, D. A., & Morris, C. (2020). Systematic review: measurement properties of patient-reported outcome measures evaluated with childhood brain tumor survivors or other acquired brain injury. Neuro Oncology Practice, 7(3), 277–287. https://doi.org/10.1093/nop/npz064

Background

Survivors of childhood brain tumors or other acquired brain injury (ABI) are at risk of poor health-related quality of life (HRQoL); its valid and reliable assessment is essential to evaluate the effect of their illness on their lives.... Read More about Systematic review: measurement properties of patient-reported outcome measures evaluated with childhood brain tumor survivors or other acquired brain injury.

Genome-wide association studies for methane production in dairy cattle (2019)
Journal Article
Calderón-Chagoya, R., Hernandez-Medrano, J. H., Ruiz-López, F. J., Garcia-Ruiz, A., Vega-Murillo, V. E., Montano-Bermudez, M., Arechavaleta-Velasco, M. E., Gonzalez-Padilla, E., Mejia-Melchor, E. I., Saunders, N., Bonilla-Cardenas, J. A., Garnsworthy, P. C., & Román-Ponce, S. I. (2019). Genome-wide association studies for methane production in dairy cattle. Genes, 10(12), Article 995. https://doi.org/10.3390/genes10120995

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Genomic selection has been proposed for the mitigation of methane (CH4) emissions by cattle because there is considerable variability in CH4 emissions between individuals fed on the same diet.... Read More about Genome-wide association studies for methane production in dairy cattle.

Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome (2019)
Journal Article
Sander, K. N., Kim, D.-H., Ortori, C. A., Warren, A. Y., Anyanwagu, U. C., Hay, D. P., Pipkin, F. B., Khan, R. N., & Barrett, D. A. (2019). Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome. Metabolomics, 15, 1-10. https://doi.org/10.1007/s11306-019-1600-8

Introduction
Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies.

Objectives
As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored unde... Read More about Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

Can exercise replace airway clearance techniques in cystic fibrosis? A survey of patients and healthcare professionals (2019)
Journal Article
Rowbotham, N., Smith, S., Davies, G., Daniels, T., Elliott, Z., Gathercole, K., Rayner, O., & Smyth, A. (2020). Can exercise replace airway clearance techniques in cystic fibrosis? A survey of patients and healthcare professionals. Journal of Cystic Fibrosis, 19(4), e19-e24. https://doi.org/10.1016/j.jcf.2019.10.026

Airway clearance techniques (ACTs) are recommended in cystic fibrosis (CF) to prevent accumulation of secretions and lung infection. “Can exercise replace chest physiotherapy for people with CF?” is one of the CF community's top 10 research questions... Read More about Can exercise replace airway clearance techniques in cystic fibrosis? A survey of patients and healthcare professionals.

Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials (2019)
Journal Article
Davies, G., Rowbotham, N. J., Smith, S., Elliot, Z. C., Gathercole, K., Rayner, O., Leighton, P. A., Herbert, S., Duff, A. J., Chandran, S., Daniels, T., Nash, E. F., & Smyth, A. R. (2020). Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials. Journal of Cystic Fibrosis, 19(3), 499-502. https://doi.org/10.1016/j.jcf.2019.10.025

In a recent James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF) the top priority clinical research question was: “What are effective ways of simplifying the treatment burden of people with CF?” We aimed to summarise the lived exp... Read More about Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials.