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Outputs (459)

Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices (2016)
Journal Article
Chou, I.-J., Wang, H.-S., Whitehouse, W. P., & Constantinescu, C. S. (in press). Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices. Current Neurology and Neuroscience Reports, 16(7), https://doi.org/10.1007/s11910-016-0663-4

Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term... Read More about Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices.

Metformin for endometrial hyperplasia (protocol) (2016)
Journal Article
Clement, N., Oliver, T. R., Shiwani, H., Sanner, J. R., Mulvaney, C. A., & Atiomo, W. (2016). Metformin for endometrial hyperplasia (protocol). Cochrane Database of Systematic Reviews, 5, Article CD012214. https://doi.org/10.1002/14651858

To determine the efficacy and safety of metformin in treating women with endometrial hyperplasia

Induction of labour at or near term for suspected fetal macrosomia (2016)
Journal Article
Boulvain, M., Irion, O., Dowswell, T., & Thornton, J. (in press). Induction of labour at or near term for suspected fetal macrosomia. Cochrane Database of Systematic Reviews, Article CD000938. https://doi.org/10.1002/14651858.CD000938.pub2

Background: Women with a suspected large-for-dates fetus or a fetus with suspected macrosomia (birthweight greater than 4000 g) are at risk of operative birth or caesarean section. The baby is also at increased risk of shoulder dystocia and trauma, i... Read More about Induction of labour at or near term for suspected fetal macrosomia.

Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos (2016)
Journal Article
Sepulveda-Rincon, L. P., Solanas, E. D. L., Serrano-Revuelta, E., Ruddick, L., Maalouf, W. E., & Beaujean, N. (2016). Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos. Theriogenology, 86(1), 91-98. https://doi.org/10.1016/j.theriogenology.2016.04.022

Despite ongoing research in a number of species, the efficiency of embryo production by nuclear transfer remains low. Incomplete epigenetic reprogramming of the nucleus introduced in the recipient oocyte is one factor proposed to limit the success of... Read More about Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos.

Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio (2016)
Journal Article
Hardy, I. C., & Maalouf, W. E. (in press). Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio. Journal of Biosocial Science, https://doi.org/10.1017/S0021932016000146

Infertility affects around 15% of human couples and in many countries approximately 1–4% of babies are born following Assisted Reproductive Technologies (ART). Several ART techniques are used and these differentially affect the sex ratio of offspring... Read More about Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio.

Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation (2016)
Journal Article
Denisenko, O., Lucas, E. S., Sun, C., Watkins, A. J., Mar, D., Bomsztyk, K., & Fleming, T. P. (2016). Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation. BBA - Biochimica et Biophysica Acta, 1859(7), 906-913. https://doi.org/10.1016/j.bbagrm.2016.04.001

Cells and organisms respond to nutrient deprivation by decreasing global rates of transcription, translation and DNA replication. To what extent such changes can be reversed is largely unknown. We examined the effect of maternal dietary restriction o... Read More about Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation.

Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours (2016)
Journal Article
Nailor, A., Walker, D. A., Jacques, T. S., Warren, K. E., Brem, H., Kearns, P. R., Greenwood, J., Penny, J. I., Pilkington, G. J., Carcaboso, A. M., Fleischhack, G., Macarthur, D., Slavc, I., Meijer, L., Gill, S., Lowis, S., van Vuurden, D. G., Pearl, M. S., Clifford, S. C., Morrissy, A. S., …Kilday, J.-P. (2016). Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours. ecancermedicalscience, 10(630), https://doi.org/10.3332/ecancer.2016.630

The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leadi... Read More about Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours.

Randomized trial of labor induction in women 35 years of age or older (2016)
Journal Article
Walker, K. F., Bugg, G. J., Macpherson, M., McCormick, C., Grace, N., Wildsmith, C., Bradshaw, L., Smith, G. C., & Thornton, J. (2016). Randomized trial of labor induction in women 35 years of age or older. New England Journal of Medicine, 374(9), https://doi.org/10.1056/NEJMoa1509117

BACKGROUND
The risk of antepartum stillbirth at term is higher among women 35 years of age or older than among younger women. Labor induction may reduce the risk of stillbirth, but it also may increase the risk of cesarean delivery, which already is... Read More about Randomized trial of labor induction in women 35 years of age or older.