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Lactic acidosis secondary to metformin overdose: a case report (2012)
Journal Article
Timbrell, S., Wilbourn, G., Harper, J., & Liddle, A. (2012). Lactic acidosis secondary to metformin overdose: a case report. Journal of Medical Case Reports, 6(230), Article 230. https://doi.org/10.1186/1752-1947-6-230

Introduction
Metformin is a commonly used treatment modality in type 2 diabetes mellitus, with a well documented side effect of lactic acidosis. In the intensive care setting lactate and pH levels are regularly used as a useful predictor of poor pro... Read More about Lactic acidosis secondary to metformin overdose: a case report.

Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss (2012)
Journal Article
Adjamian, P., Sereda, M., Zobay, O., Hall, D. A., & Palmer, A. R. (2012). Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss. Journal of the Association for Research in Otolaryngology, 13(5), https://doi.org/10.1007/s10162-012-0340-5

Tinnitus is an auditory phenomenon characterised by the perception of a sound in the absence of an external auditory stimulus. Chronic subjective tinnitus is almost certainly maintained via central mechanisms, and this is consistent with observed mea... Read More about Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss.

Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death (2012)
Journal Article
Rogers, H. A., Kilday, J.-P., Mayne, C., Ward, J., Adamowicz-Brice, M., Schwalbe, E. C., Clifford, S. C., Coyle, B., & Grundy, R. G. (2012). Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. Acta Neuropathologica, 123(5), https://doi.org/10.1007/s00401-011-0904-1

Epigenetic alterations, including methylation, have been shown to be an important mechanism of gene silencing in cancer. Ependymoma has been well characterized at the DNA copy number and mRNA expression levels. However little is known about DNA methy... Read More about Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death.

Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data (2012)
Journal Article
Orton, E., Kendrick, D., West, J., & Tata, L. J. (2012). Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data. PLoS ONE, 7(4), Article e35193. https://doi.org/10.1371/journal.pone.0035193

Background: Injuries in childhood are largely preventable yet an estimated 2,400 children die every day because of injury and violence. Despite this, the factors that contribute to injury occurrence have not been quantified at the population scale us... Read More about Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data.

Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems (2012)
Journal Article
Jbabdi, S., Sotiropoulos, S. N., Savio, A. M., Graña, M., & Behrens, T. E. (2012). Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems. Magnetic Resonance in Medicine, 68(6), https://doi.org/10.1002/mrm.24204

In this article, we highlight an issue that arises when using multiple b‐values in a model‐based analysis of diffusion MR data for tractography. The non‐monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in... Read More about Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems.

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma (2012)
Journal Article
in the microvascular niche of paediatric high grade glioma. Acta Neuropathologica, 124(1), https://doi.org/10.1007/s00401-012-0952-1

Paediatric high grade glioma (pHGG) (World Health Organisation astrocytoma grades III and IV) remains poor prognosis tumours, with a median survival of only 15 months following diagnosis. Current investigation of anti-angiogenic strategies has focuse... Read More about CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma.

Person centred dementia care: problems and possibilities (2012)
Journal Article
Argyle, E. (2012). Person centred dementia care: problems and possibilities. Working with Older People, 16(2), 69-77. https://doi.org/10.1108/13663661211231828

Purpose

Dementia care is an issue of increasing policy focus, with person centred approaches becoming synonymous with quality provision in this area. However, the implementation and efficacy of this approach is difficult to measure and there are s... Read More about Person centred dementia care: problems and possibilities.

Ball and rackets: inferring fiber fanning from diffusion-weighted MRI (2012)
Journal Article
Sotiropoulos, S. N., Behrens, T. E., & Jbabdi, S. (2012). Ball and rackets: inferring fiber fanning from diffusion-weighted MRI. NeuroImage, 60(2), https://doi.org/10.1016/j.neuroimage.2012.01.056

A number of methods have been proposed for resolving crossing fibers from diffusion-weighted (DW) MRI. However, other complex fiber geometries have drawn minimal attention. In this study, we focus on fiber orientation dispersion induced by within-vox... Read More about Ball and rackets: inferring fiber fanning from diffusion-weighted MRI.

Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database (2012)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2012). Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database. BMJ Open, 2(1), Article e000548. https://doi.org/10.1136/bmjopen-2011-000548

Introduction: Bisphosphonates are becoming
a common treatment for osteoporosis particularly after
discovery of the association between hormone
replacement therapy and increased risk of breast
cancer. As osteoporosis develops with age, treatment... Read More about Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database.