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CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma

Smith, Stuart J.; Tilly, Hanna; Ward, Jennifer H.; Macarthur, Donald C.; Lowe, James; Coyle, Beth; Grundy, Richard G.

Authors

Stuart J. Smith

Hanna Tilly

Jennifer H. Ward

Donald C. Macarthur

James Lowe

Beth Coyle

Richard G. Grundy



Abstract

Paediatric high grade glioma (pHGG) (World Health Organisation astrocytoma grades III and IV) remains poor prognosis tumours, with a median survival of only 15 months following diagnosis. Current investigation of anti-angiogenic strategies has focused on adult glioblastoma multiforme (GBM) with phase III trials targeting vascular endothelial growth factor continuing. In this study we investigated whether the degree of vascularity correlated with prognosis in a large cohort of pHGG (n = 150) and whether different vessel markers carried different prognostic value. We found that CD105 (endoglin) had a strongly significant association with poor prognosis on multivariate analysis (p =

Journal Article Type Article
Publication Date Jul 1, 2012
Journal Acta Neuropathologica
Print ISSN 0001-6322
Electronic ISSN 0001-6322
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 124
Issue 1
APA6 Citation Smith, S. J., Tilly, H., Ward, J. H., Macarthur, D. C., Lowe, J., Coyle, B., & Grundy, R. G. (2012). CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma. Acta Neuropathologica, 124(1), doi:10.1007/s00401-012-0952-1
DOI https://doi.org/10.1007/s00401-012-0952-1
Keywords Glioblastoma, Angiogenesis, Endoglin, CD133
Publisher URL http://link.springer.com/article/10.1007/s00401-012-0952-1
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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