Outputs (8)

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men (2020)
Journal Article
Swiecicka, A., Piasecki, M., Stashuk, D., Jones, D., Wu, F., McPhee, J., & Rutter, M. K. (2020). Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men. Journal of Clinical Endocrinology and Metabolism, 105(7), https://doi.org/10.1210/clinem/dgaa100

Context
Anabolic hormones are important factors in maintaining muscle mass for ageing men, but their role in overall motor unit structure and function is unclear.

Objective
To determine associations of anabolic and reproductive hormone levels wi... Read More about Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men.

The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans (2018)
Journal Article
Wilkinson, D. J., Piasecki, M., & Atherton, P. J. (2018). The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. Ageing Research Reviews, 47, 123-132. https://doi.org/10.1016/j.arr.2018.07.005

Age-related loss of skeletal muscle mass and function, sarcopenia, is associated with physical frailty and increased risk of morbidity (chronic diseases), in addition to all-cause mortality. The loss of muscle mass occurs incipiently from middle-age... Read More about The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans.

Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls (2018)
Journal Article
Piasecki, J., McPhee, J., Hannam, K., Deere, K., Elhakeem, A., Piasecki, M., Degens, H., Tobias, J., & Ireland, A. (2018). Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls. Archives of Osteoporosis, 13, https://doi.org/10.1007/s11657-018-0486-9

Summary: We examined bone density in older athletes and controls. Sprinters had greater hip and spine bone density than endurance athletes and controls, whereas values were similar in the latter two groups. These results could not be explained by dif... Read More about Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls.

Handgrip strength cannot be assumed a proxy for overall muscle strength (2018)
Journal Article
Yeung, S. S., Reijnierse, E. M., Trappenburg, M. C., Hogrel, J.-Y., McPhee, J. S., Piasecki, M., Sipila, S., Salpakoski, A., Butler-Browne, G., Pääsuke, M., Gapeyeva, H., Narici, M. V., Meskers, C. G., & Maier, A. B. (2018). Handgrip strength cannot be assumed a proxy for overall muscle strength. Journal of the American Medical Directors Association, 19(8), 703-709. https://doi.org/10.1016/j.jamda.2018.04.019

Objectives: Dynapenia, low muscle strength, is predictive for negative health outcomes and is usually expressed as handgrip strength (HGS). Whether HGS can be a proxy for overall muscle strength and whether this depends on age and health status is co... Read More about Handgrip strength cannot be assumed a proxy for overall muscle strength.

Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men (2018)
Journal Article
Piasecki, M., Ireland, A., Piasecki, J., Stashuk, D., Swiecicka, A., Rutter, M., Jones, D., & McPhee, J. (2018). Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men. Journal of Physiology, 596(9), https://doi.org/10.1113/JP275520

Sarcopenia results from the progressive loss of skeletal muscle mass and reduced function in older age. It is likely to be associated with the well‐documented reduction of motor unit numbers innervating limb muscles and the increase in size of surviv... Read More about Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men.

Motor unit number estimates and neuromuscular transmission in the tibialis anterior of master athletes: evidence that athletic older people are not spared from age-related motor unit remodeling (2016)
Journal Article
Piasecki, M., Ireland, A., Coulson, J., Stashuk, D. W., Hamilton-Wright, A., Swiecicka, A., Rutter, M. K., McPhee, J. S., & Jones, D. A. (2016). Motor unit number estimates and neuromuscular transmission in the tibialis anterior of master athletes: evidence that athletic older people are not spared from age-related motor unit remodeling. Physiological Reports, 4(19), Article e12987. https://doi.org/10.14814/phy2.12987

Muscle motor unit numbers decrease markedly in old age, while remaining motor units are enlarged and can have reduced neuromuscular junction transmission stability. However, it is possible that regular intense physical activity throughout life can at... Read More about Motor unit number estimates and neuromuscular transmission in the tibialis anterior of master athletes: evidence that athletic older people are not spared from age-related motor unit remodeling.

Age-related neuromuscular changes affecting human vastus lateralis: age-related neuromuscular changes affecting human vastus lateralis (2015)
Journal Article
Piasecki, M., Ireland, A., Stashuk, D., Hamilton-Wright, A., Jones, D., & McPhee, J. (2016). Age-related neuromuscular changes affecting human vastus lateralis: age-related neuromuscular changes affecting human vastus lateralis. Journal of Physiology, 594(16), 4525-4536. https://doi.org/10.1113/jp271087

The anterior thigh muscles are particularly susceptible to muscle loss and weakness during ageing, although how this is associated with changes to neuromuscular structure and function in terms of motor unit (MU) number, size and MU potential (MUP) st... Read More about Age-related neuromuscular changes affecting human vastus lateralis: age-related neuromuscular changes affecting human vastus lateralis.