Outputs (33)

Interventions for preventing occupational irritant hand dermatitis (Review) (2018)
Journal Article
Bauer, A., Rönsch, H., Elsner, P., Dittmar, D., Bennett, C., Schuttelaar, M.-L. A., Lukács, J., John, S. M., & Williams, H. C. (in press). Interventions for preventing occupational irritant hand dermatitis (Review). Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD004414.pub3

Background:
Occupational irritant hand dermatitis (OIHD) causes significant functional impairment, disruption of work, and discomfort in the working population. Different preventive measures such as protective gloves, barrier creams and moisturisers... Read More about Interventions for preventing occupational irritant hand dermatitis (Review).

Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) (2018)
Journal Article
Chalmers, J., Thomas, K., Apfelbacher, C., Williams, H., Prinsen, C., Spuls, P., Simpson, E., Gerbens, L., Boers, M., Barbarot, S., Stalder, J., Abuabara, K., Aoki, V., Ardeleanu, M., Armstrong, J., Bang, B., Berents, T., Burton, T., Butler, L., Chubachi, T., …Zaniboni, M. (2018). Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 178(5), e332-e341. https://doi.org/10.1111/bjd.16543

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus... Read More about Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial (2017)
Journal Article
Chalmers, J. R., Haines, R. H., Mitchell, E. J., Thomas, K. S., Brown, S. J., Ridd, M., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Bradshaw, L. E., Montgomery, A. A., Boyle, R. J., & Williams, H. C. (2017). Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial. Trials, 18(1), Article 343. https://doi.org/10.1186/s13063-017-2031-3

Background: Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a significant cost burden for... Read More about Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial.

Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial (2017)
Journal Article
Mason, J., Thomas, K., Ormerod, A., Craig, F., Mitchell, E., Norrie, J., & Williams, H. (2017). Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial. British Journal of Dermatology, 177(6), 1527-1536. https://doi.org/10.1111/bjd.15561

Background

Pyoderma gangrenosum (PG) is a painful, ulcerating skin disease with poor evidence for management. Prednisolone and ciclosporin are the most commonly used treatments, although not previously compared within a randomised controlled trial... Read More about Ciclosporin compared to prednisolone therapy for patients with pyoderma gangrenosum: cost-effectiveness analysis of the STOP GAP trial.

Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial (2017)
Journal Article
Williams, H. C., Wojnarowska, F., Kirtschig, G., Mason, J., Godec, T. R., Schmidt, E., Chalmers, J., Childs, M., Walton, S., Harman, K., Chapman, A., Whitham, D., & Nunn, A. J. (in press). Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial. Lancet, 389(10079), https://doi.org/10.1016/S0140-6736%2817%2930560-3

Background: Bullous pemphigoid (BP) is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline conveys acceptable short-term blister control whilst conferring long-term safety advantage... Read More about Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic non-inferiority randomised controlled trial.

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease (2016)
Journal Article
Thomas, K. S., Batchelor, J. M., Bath-Hextall, F., Chalmers, J., Clarke, T., Crowe, S., Delamere, F. M., Eleftheriadou, V., Evans, N., Firkins, L., Greenlaw, N., Lansbury, L. E., Lawton, S., Layfield, C., Leonardi-Bee, J., Mason, J., Mitchell, E., Nankervis, H., Norrie, J., Nunn, A., …Williams, H. C. (2016). A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease. Programme Grants for Applied Research, 4(18), https://doi.org/10.3310/pgfar04180

Background

Skin diseases are very common and can have a large impact on the quality of life of patients and caregivers. This programme addressed four diseases: (1) eczema, (2) vitiligo, (3) squamous cell skin cancer (SCC) and (4) pyoderma gangreno... Read More about A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease.

Surgery versus 5% imiquimod for nodular and superficial basal-cell carcinoma: five year results of the SINS randomised controlled trial (2016)
Journal Article
Williams, H. C., Bath-Hextall, F., Ozolins, M., Armstrong, S. J., Colver, G. B., Perkins, W., Miller, P. S., & Surgery versus Imiquimod forNodular and Superficial basal cell carcinoma (SINS) study group. (2017). Surgery versus 5% imiquimod for nodular and superficial basal-cell carcinoma: five year results of the SINS randomised controlled trial. Journal of Investigative Dermatology, 137(3), 614-619. https://doi.org/10.1016/j.jid.2016.10.019

Background: We previously reported modest clinical 3-year benefit for topical imiquimod compared with surgery for superficial or nodular basal cell carcinoma (sBCC, nBCC) at low risk sites in our non-inferiority randomised controlled SINS trial. Here... Read More about Surgery versus 5% imiquimod for nodular and superficial basal-cell carcinoma: five year results of the SINS randomised controlled trial.

Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews (2016)
Journal Article
Le Cleach, L., Doney, E., Katz, K. A., Williams, H. C., & Trinquart, L. (2016). Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews. Journal of Investigative Dermatology, 136(12), e125-e129. https://doi.org/10.1016/j.jid.2016.09.019

Clinical trials and basic science studies without statistically significant results are less likely to be published than studies with statistically significant results. Systematic reviews and meta-analyses that omit unpublished data are at high risk... Read More about Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews.

Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement (2016)
Journal Article
Spuls, P., Gerbens, L., Simpson, E., Apfelbacher, C., Chalmers, J., Thomas, K., Prinsen, C., Kobyletzki, L. V., Singh, J., Williams, H. C., & Schmitt, J. (2017). Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement. British Journal of Dermatology, 176(4), 979-984. https://doi.org/10.1111/bjd.15179

Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, q... Read More about Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement.

Shared decision-making and patient decision aids in dermatology (2016)
Journal Article
Tan, J., Linos, E., Sendelweck, M. A., van Zuuren, E. J., Ersser, S., Dellavalle, R. P., & Williams, H. C. (in press). Shared decision-making and patient decision aids in dermatology. British Journal of Dermatology, 175(5), https://doi.org/10.1111/bjd.14803

Shared decision making combines individual patient interests and values with clinical best evidence under the guiding principle of patient autonomy. Patient decision aids can support shared decision making and facilitate decisions that have multiple... Read More about Shared decision-making and patient decision aids in dermatology.