Outputs (160)

Reconstructing the last common ancestor of all eukaryotes (2024)
Journal Article
Richards, T. A., Eme, L., Archibald, J. M., Leonard, G., Coelho, S. M., de Mendoza, A., Dessimoz, C., Dolezal, P., Fritz-Laylin, L. K., Gabaldón, T., Hampl, V., Kops, G. J., Leger, M. M., Lopez-Garcia, P., McInerney, J. O., Moreira, D., Muñoz-Gómez, S. A., Richter, D. J., Ruiz-Trillo, I., Santoro, A. E., …Wideman, J. G. (2024). Reconstructing the last common ancestor of all eukaryotes. PLoS Biology, 22(11), Article e3002917. https://doi.org/10.1371/journal.pbio.3002917

Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As d... Read More about Reconstructing the last common ancestor of all eukaryotes.

POLD3 as Controller of Replicative DNA Repair (2024)
Journal Article
Alli, N., Lou-Hing, A., Bolt, E. L., & He, L. (2024). POLD3 as Controller of Replicative DNA Repair. International Journal of Molecular Sciences, 25(22), Article 12417. https://doi.org/10.3390/ijms252212417

Multiple modes of DNA repair need DNA synthesis by DNA polymerase enzymes. The eukaryotic B-family DNA polymerase complexes delta (Polδ) and zeta (Polζ) help to repair DNA strand breaks when primed by homologous recombination or single-strand DNA ann... Read More about POLD3 as Controller of Replicative DNA Repair.

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development (2024)
Journal Article
Waheed-Ullah, Q., Wilsdon, A., Abbad, A., Rochette, S., Bu'Lock, F., Saed, A. A., Hitz, M., Brook, J. D., & Loughna, S. (2025). Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development. Journal of Anatomy, 246(4), 616-630. https://doi.org/10.1111/joa.14175

Congenital heart disease (CHD) has an incidence of approximately 1%. Over the last decade, sequencing studies including large cohorts of individuals with CHD have begun to unravel the genetic mechanisms underpinning CHD. This includes the identificat... Read More about Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development.

Measuring Vaccine Responses in the Multiplex Era (2024)
Book Chapter
Ayling, K., Vedhara, K., & Fairclough, L. (2024). Measuring Vaccine Responses in the Multiplex Era. In Q. Yan (Ed.), Psychoneuroimmunology: Methods and Protocols (149-162). Springer US. https://doi.org/10.1007/978-1-0716-4200-9_9

Vaccine studies in psychoneuroimmunology (PNI) provide insight into biopsychosocial interactions and their role in infectious diseases. Methodologies to measure vaccine responses are therefore of critical importance for PNI researchers. In this chapt... Read More about Measuring Vaccine Responses in the Multiplex Era.

In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams (2024)
Journal Article
Ghasemzadeh Hasankolaei, M., Evans, N. P., Elcombe, C. S., Lea, R. G., Sinclair, K. D., Padmanabhan, V., & Bellingham, M. (2025). In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams. Environmental Research, 264, Article 120303. https://doi.org/10.1016/j.envres.2024.120303

Environmental chemicals (ECs) have been associated with a broad range of disorders and diseases. Daily exposure to various ECs in the environment, or real-life exposure, has raised significant public health concerns. Utilizing the biosolids-treated p... Read More about In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams.

Global co-regulatory cross talk between m6A and m5C RNA methylation systems coordinate cellular responses and brain disease pathways (2024)
Journal Article
Orji, O. C., Stones, J., Rajani, S., Markus, R., Demirbugen Öz, M., & Knight, H. M. (2025). Global co-regulatory cross talk between m6A and m5C RNA methylation systems coordinate cellular responses and brain disease pathways. Molecular Neurobiology, 62, 5006-5021. https://doi.org/10.1007/s12035-024-04555-0

N6 adenosine and C5 cytosine modification of mRNAs, tRNAs and rRNAs are regulated by the behaviour of distinct sets of writer, reader and eraser effector proteins which are conventionally considered to function independently. Here, we provide evidenc... Read More about Global co-regulatory cross talk between m6A and m5C RNA methylation systems coordinate cellular responses and brain disease pathways.

The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation (2024)
Journal Article
Kosch, T. A., Torres-Sánchez, M., Liedtke, H. C., Summers, K., Yun, M. H., Crawford, A. J., Maddock, S. T., Ahammed, M. S., Araújo, V. L., Bertola, L. V., Bucciarelli, G. M., Carné, A., Carneiro, C. M., Chan, K. O., Chen, Y., Crottini, A., da Silva, J. M., Denton, R. D., Dittrich, C., Espregueira Themudo, G., …Wogan, G. O. (2024). The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation. BMC Genomics, 25(1), Article 1025. https://doi.org/10.1186/s12864-024-10899-7

Amphibians represent a diverse group of tetrapods, marked by deep divergence times between their three systematic orders and families. Studying amphibian biology through the genomics lens increases our understanding of the features of this animal cla... Read More about The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.

Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years (2024)
Journal Article
Sach, T. H., Williams, H. C., Allen, H., Boyle, R., Kelleher, M., Brown, S., Cork, M., Flohr, C., Jay, N., Lartey, S., Davies, C., Lawton, S., Perkin, M., Ridd, M., Brooks, J., Tarr, S., Wyatt, L., & Thomas, K. (2024). Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years. Value in Health, https://doi.org/10.1016/j.jval.2024.08.010

Objectives
To assess the practicality, validity and responsiveness of proxy CHU-9D in children aged 2-5 years.

Methods
We used data from BEEP, a UK randomised co... Read More about Practicality, Validity, and Responsiveness of Using the Proxy Version of the Child Health Utility–9 Dimensions With Children Aged 2 to 5 Years.

Exploiting phenotypic heterogeneity to improve production of glutathione by yeast (2024)
Journal Article
Xu, M., Vallières, C., Finnis, C., Winzer, K., & Avery, S. V. (2024). Exploiting phenotypic heterogeneity to improve production of glutathione by yeast. Microbial Cell Factories, 23(1), Article 267. https://doi.org/10.1186/s12934-024-02536-5

Background: Gene expression noise (variation in gene expression among individual cells of a genetically uniform cell population) can result in heterogenous metabolite production by industrial microorganisms, with cultures containing both low- and hig... Read More about Exploiting phenotypic heterogeneity to improve production of glutathione by yeast.

A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility (2024)
Journal Article
Terada, T., Hausen, M., Mir, H., Reed, J. L., & Coutinho, T. D. (2025). A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility. CJC Open, 7(1), 110-119. https://doi.org/10.1016/j.cjco.2024.09.017

Background
Supervised exercise programs improve walking impairment and quality of life (QoL) in patients with peripheral artery disease (PAD). However, such programs are underutilized, due to their limited accessibility. A feasible and effective exe... Read More about A Hybrid Rehabilitation Program for Adults with Peripheral Artery Disease (HY-PAD): A Pre-Post Intervention Study to Assess Its Feasibility.