Outputs (194)

The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India (2020)
Journal Article
Vijay, A., Mohan, L., Taylor, M. A., Grove, J. I., Valdes, A. M., Aithal, G. P., & Shenoy, K. T. (2020). The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India. Nutrients, 12(2), Article 383. https://doi.org/10.3390/nu12020383

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dietary record tools such as food frequency questionnaire (FFQ) and food diaries (FD) are the most commonly used choices for assessing dietary intakes in most large-scale epidemiological studi... Read More about The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South Kerala, India.

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism (2020)
Journal Article
Lane, J. R., Abramyan, A. M., Adhikari, P., Keen, A. C., Lee, K.-H., Sanchez, J., Verma, R. K., Lim, H. D., Yano, H., Javitch, J. A., & Shi, L. (2020). Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism. eLife, 9, Article e52189. https://doi.org/10.7554/elife.52189

By analyzing and simulating inactive conformations of the highly-homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r... Read More about Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism.

Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis (2020)
Journal Article
Kapoor, P., Briggs, D. A., Cox, M. H., & Kerr, I. D. (2020). Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis. International Journal of Molecular Sciences, 21(3), Article 759. https://doi.org/10.3390/ijms21030759

ABCG2 is one of a triumvirate of human multidrug ATP binding cassette (ABC) transporters that are implicated in defense of cells and tissues against cytotoxic chemicals, but which can confer chemotherapy resistance states in oncology. Understanding t... Read More about Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis.

Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections (2020)
Journal Article
Kurmoo, Y., Hook, A. L., Harvey, D., Dubern, J.-F., Williams, P., Morgan, S. P., Korposh, S., & Alexander, M. R. (2020). Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections. Biomaterials Science, 8(5), 1464-1477. https://doi.org/10.1039/c9bm00875f

Real time monitoring of bacterial attachment to medical devices provides opportunities to detect early biofilm formation and instigate appropriate interventions before infection develops. This study utilises long period grating (LPG) optical fibre se... Read More about Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections.

Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management (2020)
Journal Article
Fone, K. C., Watson, D. J., Billiras, R. I., Sicard, D. I., Dekeyne, A., Rivet, J.-M., Gobert, A., & Millan, M. J. (2020). Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management. Molecular Neurobiology, 57, 2144–2166. https://doi.org/10.1007/s12035-020-01875-9

© 2020, The Author(s). Frontocortical NMDA receptors are pivotal in regulating cognition and mood, are hypofunctional in schizophrenia, and may contribute to autistic spectrum disorders. Despite extensive interest in agents potentiating activity at t... Read More about Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management.

Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota (2020)
Journal Article
Whelan, F. J., Waddell, B., Syed, S. A., Shekarriz, S., Rabin, H. R., Parkins, M. D., & Surette, M. G. (2020). Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota. Nature Microbiology, 5, 379-390. https://doi.org/10.1038/s41564-019-0643-y

Amplicon sequencing (for example, of the 16S rRNA gene) identifies the presence and relative abundance of microbial community members. However, metagenomic sequencing is needed to identify the genetic content and functional potential of a community.... Read More about Culture-enriched metagenomic sequencing enables in-depth profiling of the cystic fibrosis lung microbiota.

Pre- and post-copulatory traits working in concert: sexual dichromatism in passerines is associated with sperm morphology (2020)
Journal Article
Durrant, K. L., Reader, T., & Symonds, M. R. E. (2020). Pre- and post-copulatory traits working in concert: sexual dichromatism in passerines is associated with sperm morphology. Biology Letters, 16(1), 20190568. https://doi.org/10.1098/rsbl.2019.0568

Passerine birds produce costly traits under intense sexual selection, including elaborate sexually dichromatic plumage and sperm morphologies, to compete for fertilizations. Plumage and sperm traits vary markedly among species, but it is unknown if t... Read More about Pre- and post-copulatory traits working in concert: sexual dichromatism in passerines is associated with sperm morphology.

Flipping Shells! Unwinding LR Asymmetry in Mirror-Image Molluscs (2020)
Journal Article
Davison, A. (2020). Flipping Shells! Unwinding LR Asymmetry in Mirror-Image Molluscs. Trends in Genetics, 36(3), 189-202. https://doi.org/10.1016/j.tig.2019.12.003

© 2019 In seeking to understand the establishment of left–right (LR) asymmetry, a limiting factor is that most animals are ordinarily invariant in their asymmetry, except when manipulated or mutated. It is therefore surprising that the wider scientif... Read More about Flipping Shells! Unwinding LR Asymmetry in Mirror-Image Molluscs.

11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Idiopathic Intracranial Hypertension: A Double-Blind Randomized Controlled Trial (2020)
Journal Article
Tomlinson, J. W., Markey, K., Mitchell, J., Botfield, H., Ottridge, R. S., Lavery, G. G., Mollan, S. P., Sinclair, A. J., Arlt, W., Matthews, T., Krishnan, A., Woolley, R., Westgate, C., Yiangou, A., Scotton, W., Fairclough, R., Singhal, R., Stewart, P. M., Taylor, A. E., Alimajstorovic, Z., …Jenkinson, C. (2020). 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Idiopathic Intracranial Hypertension: A Double-Blind Randomized Controlled Trial. Brain Communications, 2(1), Article fcz050. https://doi.org/10.1093/braincomms/fcz050

Treatment options for idiopathic intracranial hypertension are limited. The enzyme 11β-hydroxysteroid dehydrogenase type 1 has been implicated in regulating cerebrospinal fluid secretion, and its activity is associated with alterations in intracrania... Read More about 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Idiopathic Intracranial Hypertension: A Double-Blind Randomized Controlled Trial.

Formin, an opinion (2020)
Journal Article
Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Wade, C. M., Chiba, S., Jackson, D. J., Levin, M., & Blaxter, M. L. (2020). Formin, an opinion. Development, 147(1), Article dev187427. https://doi.org/10.1242/dev.187427