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Outputs (213)

Penetration and intracellular uptake of poly(glycerol-adipate)nanoparticles into 3-dimensional brain tumour cell culture models (2016)
Journal Article
Meng, W., Garnett, M. C., Walker, D. A., & Parker, T. L. (2016). Penetration and intracellular uptake of poly(glycerol-adipate)nanoparticles into 3-dimensional brain tumour cell culture models. Experimental Biology and Medicine, 241(5), https://doi.org/10.1177/1535370215610441

Nanoparticle (NP) drug delivery systems may potentially enhance the efficacy of therapeutic agents. It is difficult to characterise many important properties of NPs in vivo and therefore attempts have been made to use realistic in vitro multicellular... Read More about Penetration and intracellular uptake of poly(glycerol-adipate)nanoparticles into 3-dimensional brain tumour cell culture models.

Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase (2016)
Journal Article
Igetei, J. E., Liddell, S., El-Faham, M., & Doenhoff, M. J. (2016). Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase. Parasitology, 143(5), 646-657. https://doi.org/10.1017/S0031182016000184

A serine protease-like enzyme found in detergent extracts of Schistosoma mansoni adult worms perfused from infected mice has been purified from mouse blood and further characterized. The enzyme is approximately 85 kDa and hydrolyses N-acetyl-DL-pheny... Read More about Purification of a chymotrypsin-like enzyme present on adult Schistosoma mansoni worms from infected mice and its characterization as a host carboxylesterase.

Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog (2016)
Journal Article
Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Koutsovoulos, G. D., Liu, M. M., Hulpiau, P., Roy, F. V., Wade, C. M., Banerjee, R., Yang, F., Chiba, S., Davey, J. W., Jackson, D. J., Levin, M., & Blaxter, M. L. (2016). Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog. Current Biology, 26(5), 654-660. https://doi.org/10.1016/j.cub.2015.12.071

While components of the pathway that establishes left-right asymmetry have been identified in diverse animals, from vertebrates to flies, it is striking that the genes involved in the first symmetry-breaking step remain wholly unknown in the most obv... Read More about Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.

The role of kinetic context in apparent biased agonism at GPCRs (2016)
Journal Article
Javitch, J. A., Klein Herenbrink, C., Sykes, D. A., Donthamsetti, P., Canals, M., Coudrat, T., Shonberg, J., Scammells, P. J., Capuano, B., Sexton, P. M., Charlton, S. J., Javitch, J., Christopoulos, A., & Lane, J. R. (2016). The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications, 7, Article 10842. https://doi.org/10.1038/ncomms10842

Biased agonism describes the ability of ligands to stabilize different conformations of a GPCR linked to distinct functional outcomes and offers the prospect of designing pathway-specific drugs that avoid on-target side effects. This mechanism is usu... Read More about The role of kinetic context in apparent biased agonism at GPCRs.

The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts (2016)
Journal Article
Aleskandarany, M. A., Agarwal, D., Negm, O. H., Ball, G., Elmouna, A., Ashankyty, I., Nuglozeh, E., Fazaludeen, M. F., Diez-Rodriguez, M., Nolan, C. C., Tighe, P. J., Green, A. R., Ellis, I. O., & Rakha, E. A. (2016). The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts. Breast Cancer Research and Treatment, 156(1), 9-20. https://doi.org/10.1007/s10549-016-3709-z

Signal transducer and activator of transcription (STAT) transcription factors family are involved in diverse cellular biological functions. Reports regarding the prognostic impact of STAT3 expression in breast cancer (BC) are variable whether being a... Read More about The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts.

Biogeographic distribution and habitat association of Ammonia genetic variants around the coastline of Great Britain (2016)
Journal Article
Saad, S., & Wade, C. (2016). Biogeographic distribution and habitat association of Ammonia genetic variants around the coastline of Great Britain. Marine Micropaleontology, 124, 54-62. https://doi.org/10.1016/j.marmicro.2016.01.004

High morphological variation and the lack of clearly defined morphological criteria for identification have led to difficulties in the identification of species in the foraminiferal genus Ammonia. It is often difficult to decide if morphological vari... Read More about Biogeographic distribution and habitat association of Ammonia genetic variants around the coastline of Great Britain.

Stepwise evolution of Elk-1 in early deuterostomes (2016)
Journal Article
Saxton, J., Ferjentsik, Z., Ducker, C., & Shaw, P. E. (in press). Stepwise evolution of Elk-1 in early deuterostomes. FEBS Journal, 283(6), https://doi.org/10.1111/febs.13607

Metazoans have multiple ETS paralogues with overlapping or indiscriminate biological functions. Elk- 1, one of three mammalian Ternary Complex Factors (TCFs), is a well-conserved, ETS domain-containing transcriptional regulator of mitogen-responsive... Read More about Stepwise evolution of Elk-1 in early deuterostomes.

Glycosylated notch and cancer (2016)
Journal Article
Pakkiriswami, S., Couto, A., Nagarajan, U., & Georgiou, M. (2016). Glycosylated notch and cancer. Frontiers in Oncology, 6(37), https://doi.org/10.3389/fonc.2016.00037

Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch an... Read More about Glycosylated notch and cancer.

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors (2016)
Journal Article
Shang, Y., Yeatman, H., Provasi, D., Alt, A., Christopoulos, A., Canals, M., & Filizola, M. (2016). Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors. ACS Chemical Biology, 11(5), 1220-1229. https://doi.org/10.1021/acschembio.5b00712

Available crystal structures of opioid receptors provide a high-resolution picture of ligand binding at the primary ("orthosteric") site, that is, the site targeted by endogenous ligands. Recently, positive allosteric modulators of opioid receptors h... Read More about Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.