Outputs (3)

Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study (2024)
Journal Article
Kalenderski, K., Dubern, J.-F., Lewis-Lloyd, C., Jeffery, N., Heeb, S., Irvine, D. J., Sloan, T. J., Birch, B., Andrich, D., Humes, D., Alexander, M. R., & Williams, P. (2024). Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study. Journal of Urology Open PLus, 2(1), Article e00005. https://doi.org/10.1097/JU9.0000000000000097

Purpose: Biofilm formation and biomineralization on urinary catheters may cause severe complications including infection and obstruction. Here, we describe an in vitro evaluation and prospective pilot clinical study of a silicone catheter coated with... Read More about Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study.

Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China (2024)
Journal Article
Baker, M., Zhang, X., Maciel-Guerra, A., Babaarslan, K., Dong, Y., Wang, W., Hu, Y., Renney, D., Liu, L., Li, H., Hossain, M., Heeb, S., Tong, Z., Pearcy, N., Zhang, M., Geng, Y., Zhao, L., Hao, Z., Senin, N., Chen, J., …Dottorini, T. (2024). Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China. Nature Communications, 15, Article 206. https://doi.org/10.1038/s41467-023-44272-1

Sharing of genetic elements among different pathogens and commensals inhabiting same hosts and environments has significant implications for antimicrobial resistance (AMR), especially in settings with high antimicrobial exposure. We analysed 661 Esch... Read More about Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China.

Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections (2024)
Journal Article
Soukarieh, F., Mashabi, A., Richardson, W., Oton, E. V., Romero, M., Dubern, J.-F., Robertson, S. N., Lucanto, S., Markham-Lee, Z., Sou, T., Kukavica-Ibrulj, I., Levesque, R. C., Bergstrom, C. A., Halliday, N., Kellam, B., Emsley, J., Heeb, S., Williams, P., Stocks, M. J., & Cámara, M. (2024). Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections. Journal of Medicinal Chemistry, 67(2), 1008-1023. https://doi.org/10.1021/acs.jmedchem.3c00973

Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS), a bacterial cell to c... Read More about Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections.