Outputs (3)

Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke (2016)
Journal Article
Maniskas, M. E., Roberts, J. M., Trueman, R. C., Learoyd, A. E., Gorman, A., Fraser, J. F., & Bix, G. J. (in press). Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. Journal of NeuroInterventional Surgery, 10(1), https://doi.org/10.1136/neurintsurg-2016-012793

Background: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. The completed Efficacy of Nitr... Read More about Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke.

Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage (2016)
Journal Article
Steventon, J. J., Trueman, R. C., Ma, D., Yhnell, E., Bayram-Weston, Z., Modat, M., Cardoso, J., Ourselin, S., Lythgoe, M., Stewart, A. J., Rosser, A. E., & Jones, D. K. (2016). Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage. Scientific Reports, 6(1), 1-12. https://doi.org/10.1038/srep32423

Huntington’s disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional ex vivo analyses, beset by tissue fixation issues. In vivo longitudinal mag... Read More about Longitudinal in vivo MRI in a Huntington’s disease mouse model: Global atrophy in the absence of white matter microstructural damage.

Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment (2016)
Journal Article
Trueman, R. C., Diaz, C., Farr, T. D., Harrison, D. J., Fuller, A., Tokarczuk, P. F., Stewart, A. J., Paisey, S. J., & Dunnett, S. B. (2017). Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment. Journal of Cerebral Blood Flow and Metabolism, 37(4), 1349-1361. https://doi.org/10.1177/0271678X16654921

In order to test therapeutics, functional assessments are required. In pre-clinical stroke research, there is little consensus regarding the most appropriate behavioural tasks to assess deficits; especially when testing over extended times in milder... Read More about Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment.