Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D₂ Receptor
(2025)
Journal Article
Lim, H. D., Bartuzi, D., Keen, A. C., Rauffenbart, C., Glenn, J., Charlton, S. J., Lovera, S., Sands, Z. A., Ates, A., Wood, M., Canals, M., Javitch, J. A., Carlsson, J., & Lane, J. R. (2025). Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D₂ Receptor. ACS Chemical Neuroscience, https://doi.org/10.1021/acschemneuro.5c00105
Recently, the first small-molecule positive allosteric modulators (PAMs) of the dopamine D2 receptor (D2R) were identified. The more potent PAM potentiated the effects of D2R signaling in vitro and in an in vivo model predictive of anti-Parkinson’s e... Read More about Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D₂ Receptor.