Outputs (33)

Secreted factors of Aspergillus fumigatus cause lung epithelial barrier disruption: A study using an air–liquid interface cell culture model (2025)
Journal Article
Barros, B. C. S. C., Barros, D. T. L., Brock, M., Toledo, M. S., Serrano, S. M. T., Suzuki, E., & Ghaemmaghami, A. M. (2025). Secreted factors of Aspergillus fumigatus cause lung epithelial barrier disruption: A study using an air–liquid interface cell culture model. Medical Mycology, 63(3), Article myaf018. https://doi.org/10.1093/mmy/myaf018

The effects of Aspergillus fumigatus-conditioned medium (AFCM) on the integrity of the Calu-3 cell lung epithelial barrier were investigated. AFCM led to a decrease in transepithelial electrical resistance and the disruption of the occludin network i... Read More about Secreted factors of Aspergillus fumigatus cause lung epithelial barrier disruption: A study using an air–liquid interface cell culture model.

Genomic Analysis of Aspergillus Section Terrei Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation (2024)
Journal Article
Theobald, S., Vesth, T. C., Geib, E., Nybo, J. L., Frisvad, J. C., Larsen, T. O., Kuo, A., LaButti, K., Lyhne, E. K., Kjærbølling, I., Ledsgaard, L., Barry, K., Clum, A., Chen, C., Nolan, M., Sandor, L., Lipzen, A., Mondo, S., Pangilinan, J., Salamov, A., …Andersen, M. R. (2024). Genomic Analysis of Aspergillus Section Terrei Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation. Journal of Fungi, 10(7), Article 507. https://doi.org/10.3390/jof10070507

Aspergillus terreus has attracted interest due to its application in industrial biotechnology, particularly for the production of itaconic acid and bioactive secondary metabolites. As related species also seem to possess a prosperous secondary metabo... Read More about Genomic Analysis of Aspergillus Section Terrei Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation.

The chemotrophic behaviour of Aspergillus niger: Mapping hyphal filaments during chemo-sensing; the first step towards directed materials formation (2024)
Journal Article
Sadaf, A., Brock, M., & Perry, C. C. (2024). The chemotrophic behaviour of Aspergillus niger: Mapping hyphal filaments during chemo-sensing; the first step towards directed materials formation. Fungal Biology, 128(4), 1868-1875. https://doi.org/10.1016/j.funbio.2024.05.010

In the development of fungal based materials for applications in construction through to biomedical materials and fashion, understanding how to regulate and direct growth is key for gaining control over the form of material generated. Here, we show h... Read More about The chemotrophic behaviour of Aspergillus niger: Mapping hyphal filaments during chemo-sensing; the first step towards directed materials formation.

Two novel species of arctic-alpine lichen-forming fungi (Ascomycota, Megasporaceae) from the Deosai Plains, Pakistan (2024)
Journal Article
Usman, M., Dyer, P. S., Brock, M., Wade, C. M., & Khalid, A. N. (2024). Two novel species of arctic-alpine lichen-forming fungi (Ascomycota, Megasporaceae) from the Deosai Plains, Pakistan. MycoKeys, 102, 285-299. https://doi.org/10.3897/mycokeys.102.113310

Members of the lichen-forming fungal genus Oxneriaria are known to occur in cold polar and high altitudinal environments. Two new species, Oxneriaria crittendenii and O. deosaiensis, are now described from the high altitude Deosai Plains, Pakistan, b... Read More about Two novel species of arctic-alpine lichen-forming fungi (Ascomycota, Megasporaceae) from the Deosai Plains, Pakistan.

CRISPR-based tools for targeted genetic manipulation in pathogenic Sporothrix species (2023)
Journal Article
species. Microbiology Spectrum, 11(5), Article e0507822. https://doi.org/10.1128/spectrum.05078-22

is an emerging fungal pathogen frequently associated with zoonotic transmission of sporotrichosis by contaminated cats. Within 25 years, the disease has spread not only throughout Brazil but now to neighboring countries in Latin America. Thermo-dimo... Read More about CRISPR-based tools for targeted genetic manipulation in pathogenic Sporothrix species.

Powerful and Real-Time Quantification of Antifungal Efficacy against Triazole-Resistant and -Susceptible Aspergillus fumigatus Infections in Galleria mellonella by Longitudinal Bioluminescence Imaging. (2023)
Journal Article
Vanhoffelen, E., Michiels, L., Brock, M., Lagrou, K., Reséndiz-Sharpe, A., & Vande Velde, G. (2023). Powerful and Real-Time Quantification of Antifungal Efficacy against Triazole-Resistant and -Susceptible Aspergillus fumigatus Infections in Galleria mellonella by Longitudinal Bioluminescence Imaging. Microbiology Spectrum, 11(4), Article e0082523. https://doi.org/10.1128/spectrum.00825-23

Aspergillus fumigatus is an environmental mold that causes life-threatening respiratory infections in immunocompromised patients. The plateaued effectiveness of antifungal therapy and the increasing prevalence of triazole-resistant isolates have led... Read More about Powerful and Real-Time Quantification of Antifungal Efficacy against Triazole-Resistant and -Susceptible Aspergillus fumigatus Infections in Galleria mellonella by Longitudinal Bioluminescence Imaging..

Characterisation of ascocorynin biosynthesis in the purple jellydisc fungus Ascocoryne sarcoides (2022)
Journal Article
Wieder, C., Peres da Silva, R., Witts, J., Jaeger, C. M., Geib, E., & Brock, M. (2022). Characterisation of ascocorynin biosynthesis in the purple jellydisc fungus Ascocoryne sarcoides. Fungal Biology and Biotechnology, 9, Article 8. https://doi.org/10.1186/s40694-022-00138-7

Background: Non-ribosomal peptide synthetase-like (NRPS-like) enzymes are highly enriched in fungal genomes and can be discriminated into reducing and non-reducing enzymes. Non-reducing NRPS-like enzymes possess a C-terminal thioesterase domain that... Read More about Characterisation of ascocorynin biosynthesis in the purple jellydisc fungus Ascocoryne sarcoides.

Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis (2022)
Journal Article
Resendiz-Sharpe, A., da Silva, R. P., Geib, E., Vanderbeke, L., Seldeslachts, L., Hupko, C., Brock, M., Lagrou, K., & Vande Velde, G. (2022). Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis. Disease Models and Mechanisms, 15(3), Article dmm049165. https://doi.org/10.1242/dmm.049165

Invasive pulmonary aspergillosis (IPA) caused by the mold Aspergillus fumigatus is one of the most important life-threatening infections in immunocompromised patients. The alarming increase of isolates resistant to the first-line recommended antifung... Read More about Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis.

Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model (2021)
Journal Article
Seldeslachts, L., Vanderbeke, L., Fremau, A., Reséndiz-Sharpe, A., Jacobs, C., Laeveren, B., Ostyn, T., Naesens, L., Brock, M., Van De Veerdonk, F. L., Humblet-Baron, S., Verbeken, E., Lagrou, K., Wauters, J., & Vande Velde, G. (2021). Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model. Virulence, 12(1), 2493-2508. https://doi.org/10.1080/21505594.2021.1974327

Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immunocompetent... Read More about Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model.

Identification of Disease-Associated Cryptococcal Proteins Reactive With Serum IgG From Cryptococcal Meningitis Patients (2021)
Journal Article
Gressler, A. E., Volke, D., Firacative, C., Schnabel, C. L., Müller, U., Krizsan, A., Schulze-Richter, B., Brock, M., Brombacher, F., Escandón, P., Hoffmann, R., & Alber, G. (2021). Identification of Disease-Associated Cryptococcal Proteins Reactive With Serum IgG From Cryptococcal Meningitis Patients. Frontiers in Immunology, 12, Article 709695. https://doi.org/10.3389/fimmu.2021.709695

Cryptococcus neoformans, an opportunistic fungal pathogen ubiquitously present in the environment, causes cryptococcal meningitis (CM) mainly in immunocompromised patients, such as AIDS patients. We aimed to identify disease-associated cryptococcal p... Read More about Identification of Disease-Associated Cryptococcal Proteins Reactive With Serum IgG From Cryptococcal Meningitis Patients.