Outputs (6)

Understanding conceptus-maternal interactions: what tools do we need to develop? (2023)
Journal Article
Butt, Z., Tinning, H., O'Connell, M. J., Fenn, J., Alberio, R., & Forde, N. (2023). Understanding conceptus-maternal interactions: what tools do we need to develop?. Reproduction, Fertility and Development, 36(2), 81-92. https://doi.org/10.1071/RD23181

Communication between the maternal endometrium and developing embryo/conceptus is critical to support successful pregnancy to term. Studying the peri-implantation period of pregnancy is critical as this is when most pregnancy loss occurs in cattle. O... Read More about Understanding conceptus-maternal interactions: what tools do we need to develop?.

Marine mammal genomes: Important resources for unravelling adaptation and evolution in the marine environment (2023)
Journal Article
Zhang, P., Goodman, S. J., O’Connell, M. J., Bai, S., & Li, S. (2023). Marine mammal genomes: Important resources for unravelling adaptation and evolution in the marine environment. Cell, 1(2), Article 100022. https://doi.org/10.59717/j.xinn-geo.2023.100022

Caecilian Genomes Reveal the Molecular Basis of Adaptation and Convergent Evolution of Limblessness in Snakes and Caecilians (2023)
Journal Article
Ovchinnikov, V., Uliano-Silva, M., Wilkinson, M., Wood, J., Smith, M., Oliver, K., Sims, Y., Torrance, J., Suh, A., McCarthy, S. A., Durbin, R., & O’Connell, M. J. (2023). Caecilian Genomes Reveal the Molecular Basis of Adaptation and Convergent Evolution of Limblessness in Snakes and Caecilians. Molecular Biology and Evolution, 40(5), 1-11. https://doi.org/10.1093/molbev/msad102

We present genome sequences for the caecilians Geotrypetes seraphini (3.8 Gb) and Microcaecilia unicolor (4.7 Gb), representatives of a limbless, mostly soil-dwelling amphibian clade with reduced eyes, and unique putatively chemosensory tentacles. Mo... Read More about Caecilian Genomes Reveal the Molecular Basis of Adaptation and Convergent Evolution of Limblessness in Snakes and Caecilians.

A burst of genomic innovation at the origin of placental mammals mediated embryo implantation (2023)
Journal Article
Taylor, A. S., Tinning, H., Ovchinnikov, V., Edge, J., Smith, W., Pullinger, A. L., Sutton, R. A., Constantinides, B., Wang, D., Forbes, K., Forde, N., & O'Connell, M. J. (2023). A burst of genomic innovation at the origin of placental mammals mediated embryo implantation. Communications Biology, 6, Article 459. https://doi.org/10.1038/s42003-023-04809-y

The origin of embryo implantation in mammals ~148 million years ago was a dramatic shift in reproductive strategy, yet the molecular changes that established mammal implantation are largely unknown. Although progesterone receptor signalling predates... Read More about A burst of genomic innovation at the origin of placental mammals mediated embryo implantation.

MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function (2023)
Journal Article
Hume, L., Edge, J. C., Tinning, H., Wang, D., Taylor, A. S., Ovchinnikov, V., Geijer-Simpson, A., Vrljicak, P., Brosens, J. J., Lucas, E. S., Simson, N. A., Shillito, J., Forbes, K., O’Connell, M. J., & Forde, N. (2023). MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function. iScience, 26(4), Article 106339. https://doi.org/10.1016/j.isci.2023.106339

We tested the hypothesis that conserved placental mammal-specific microRNAs and their targets facilitate endometrial receptivity to implantation. Expression of miR-340-5p, -542-3p, and -671-5p was regulated by exposure of endometri... Read More about MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function.

Improving Orthologous Signal and Model Fit in Datasets Addressing the Root of the Animal Phylogeny (2023)
Journal Article
McCarthy, C. G., Mulhair, P. O., Siu-Ting, K., Creevey, C. J., & O’Connell, M. J. (2023). Improving Orthologous Signal and Model Fit in Datasets Addressing the Root of the Animal Phylogeny. Molecular Biology and Evolution, 40(1), Article msac276. https://doi.org/10.1093/molbev/msac276

There is conflicting evidence as to whether Porifera (sponges) or Ctenophora (comb jellies) comprise the root of the animal phylogeny. Support for either a Porifera-sister or Ctenophore-sister tree has been extensively examined in the context of mode... Read More about Improving Orthologous Signal and Model Fit in Datasets Addressing the Root of the Animal Phylogeny.