High-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits
(2024)
Journal Article
Farzand, R., Kimani, M. W., Mourkas, E., Jama, A., Clark, J. L., De Ste Croix, M., Monteith, W. M., Lucidarme, J., Oldfield, N. J., Turner, D. P. J., Borrow, R., Martinez-Pomares, L., Sheppard, S. K., & Bayliss, C. D. (2024). High-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits. mBio, 15(12), Article e03059-24. https://doi.org/10.1128/mbio.03059-24
Genome-wide association studies (GWAS) with binary or single phenotype data have successfully identified disease-associated genotypes and determinants of antimicrobial resistance. We describe a novel phenotype-to-genotype approach for a major bacteri... Read More about High-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits.