Outputs (5)

Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair (2025)
Journal Article
Yeh, V., Goode, A., Khunti, N., Watts, J., Parmenter, C., Fay, M., Johnson, D., Cowieson, N., & Bonev, B. (2025). Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair. Journal of the American Chemical Society, https://doi.org/10.1021/jacs.5c07146

Performance plastics, such as poly(methyl methacrylate), underpin the modern economy. Global manufacturing of plastic precursors relies on fossil carbon sources, and the urgently needed shift toward renewable carbon use through biofermentation is hin... Read More about Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair.

Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate (2023)
Journal Article
Bardelang, P., Murray, E. J., Blower, I., Zandomeneghi, S., Goode, A., Hussain, R., Kumari, D., Siligardi, G., Inoue, K., Luckett, J., Doutch, J., Emsley, J., Chan, W. C., Hill, P., Williams, P., & Bonev, B. B. (2023). Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Frontiers in Chemistry, 11, Article 1113885. https://doi.org/10.3389/fchem.2023.1113885

Virulence gene expression in the human pathogen, S. aureus is regulated by the agr (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse Gram-positive bacteria. The agr QS signal molecule is an autoinducing peptide (AIP)... Read More about Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate.

Interactions of polymyxin B with lipopolysaccharide-containing membranes (2021)
Journal Article
Goode, A., Yeh, V., & Bonev, B. B. (2021). Interactions of polymyxin B with lipopolysaccharide-containing membranes. Faraday Discussions, 232, 317-329. https://doi.org/10.1039/d1fd00036e

Bacterial resistance to antibiotics constantly remodels the battlefront between infections and antibiotic therapy. Polymyxin B, a cationic peptide with an anti-Gram-negative spectrum of activity is re-entering use as a last resort measure and as an a... Read More about Interactions of polymyxin B with lipopolysaccharide-containing membranes.

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences (2015)
Journal Article
Kerr, I., Haider, A. J., Cox, M. H., Jones, N., Goode, A. J., Bridge, K. S., Wong, K., & Briggs, D. (2015). Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences. Bioscience Reports, 35(4), Article e00241. https://doi.org/10.1042/BSR20150150

ABCG2 is an ABC (ATP-binding cassette) transporter with a physiological role in urate transport in the kidney and is also implicated in multi-drug efflux from a number of organs in the body. The trafficking of the protein and the mechanism by which i... Read More about Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function (2014)
Journal Article
Goode, A., Long, J. E., Shaw, B., Ralston, S. H., Visconti, M. R., Gianfrancesco, F., Esposito, T., Gennari, L., Merlotti, D., Rendina, D., Rea, S. L., Sultana, M., Searle, M. S., & Layfield, R. (2014). Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function. BBA - Molecular Basis of Disease, 1842(7), 992-1000. https://doi.org/10.1016/j.bbadis.2014.03.006

SQSTM1 mutations are common in patients with Paget disease of bone (PDB), with most affecting the C-terminal ubiquitin-associated (UBA) domain of the SQSTM1 protein. We performed structural and functional analyses of two UBA domain mutations, an I424... Read More about Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function.